ID VCaP AC CVCL_2235 SY VCAP; Vcap; Vertebral Cancer of the Prostate DR BTO; BTO_0003215 DR CLO; CLO_0037117 DR EFO; EFO_0007752 DR AddexBio; C0019001/73 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-2876 DR BioSample; SAMN03473238 DR BioSample; SAMN05292448 DR BioSample; SAMN10988209 DR cancercelllines; CVCL_2235 DR CCRID; 3101HUMSCSP5034 DR CCRID; 3101HUMTCHu220 DR Cell_Model_Passport; SIDM01077 DR ChEMBL-Cells; CHEMBL4295435 DR ChEMBL-Targets; CHEMBL4296508 DR CLS; 300631 DR Cosmic; 1028646 DR Cosmic; 1028698 DR Cosmic; 1043330 DR Cosmic; 1071482 DR Cosmic; 1689710 DR Cosmic; 1995663 DR Cosmic; 2580131 DR Cosmic-CLP; 1299075 DR DepMap; ACH-000115 DR ECACC; 06020201 DR EGA; EGAS00001000978 DR ENCODE; ENCBS316RCQ DR ENCODE; ENCBS626UQL DR GDSC; 1299075 DR GEO; GSM525805 DR GEO; GSM648824 DR GEO; GSM887731 DR GEO; GSM888826 DR GEO; GSM1374984 DR GEO; GSM1440913 DR GEO; GSM1440914 DR GEO; GSM1633311 DR GEO; GSM1633312 DR GEO; GSM1633313 DR GEO; GSM1670571 DR GEO; GSM2069530 DR GEO; GSM2069531 DR GEO; GSM2069532 DR GEO; GSM2069533 DR GEO; GSM2069534 DR GEO; GSM2069535 DR GEO; GSM2069536 DR GEO; GSM2069537 DR GEO; GSM3145594 DR GEO; GSM3145745 DR GEO; GSM3407124 DR GEO; GSM3407125 DR GEO; GSM3407126 DR GEO; GSM3407127 DR GEO; GSM3407128 DR GEO; GSM3407129 DR GEO; GSM5402196 DR IARC_TP53; 18891 DR IZSLER; BS TCL 234 DR LiGeA; CCLE_269 DR LINCS_LDP; LCL-1147 DR PharmacoDB; VCaP_1653_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_2235 DR PubChem_Cell_line; CVCL_2235 DR Wikidata; Q29511246 RX CelloPub=CLPUB00698; RX PubMed=11317522; RX PubMed=14518029; RX PubMed=14518030; RX PubMed=21698104; RX PubMed=22460905; RX PubMed=23447416; RX PubMed=23615946; RX PubMed=23671654; RX PubMed=25877200; RX PubMed=25984343; RX PubMed=27397505; RX PubMed=28145883; RX PubMed=29194687; RX PubMed=30244336; RX PubMed=30305041; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31395879; RX PubMed=31978347; RX PubMed=34402095; RX PubMed=35839778; RX PubMed=38892296; WW Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/atcc-crl-2876-growth-and-morphology WW Info; ECACC; -; https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/vcap/ WW Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544522 WW Info; Wikipedia; -; https://en.wikipedia.org/wiki/VCaP CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: TCGA-110-CL cell line panel. CC Population: Caucasian. CC Characteristics: Established from a xenograft produced by implantation of tumor cells in a SCID mouse. CC Virology: Contains an integrated xenotropic MuLV-related virus (XMRV) Bxv-1 (PubMed=21698104). CC Doubling time: 220 hours (PubMed=25984343); ~53 hours (ATCC=CRL-2876); ~51 hours (PBCF); 126.45 hours (JWGray panel). CC Microsatellite instability: Stable (MSS) (PubMed=23671654; Sanger). CC Sequence variation: Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:11876; TMPRSS2; Name(s)=TMPRSS2-ERG (PubMed=23447416; PubMed=23615946). CC Sequence variation: Mutation; HGNC; HGNC:7127; MLH1; Simple; p.Ile219Val (c.655A>G); ClinVar=VCV000036557; Zygosity=Homozygous (PubMed=23615946). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (PubMed=14518029; PubMed=23615946; Cosmic-CLP=1299075; DepMap=ACH-000115). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Phenotyping; shRNA library screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=0.05%; East Asian, North=1.4%; East Asian, South=0%; South Asian=0.98%; European, North=69.8%; European, South=27.77% (PubMed=30894373). CC Derived from site: Metastatic; Bone, vertebra; UBERON=UBERON_0002412. ST Source(s): AddexBio=C0019001/73; ATCC=CRL-2876; CCRID; CLS=300631; Cosmic-CLP=1299075; ECACC=06020201; IZSLER=BS TCL 234; PubMed=14518029; PubMed=25877200; Technion Genomics Center ST Amelogenin: X,Y ST CSF1PO: 10,12 ST D10S1248: 13,14 ST D12S391: 21,23 ST D13S317: 11,12 ST D16S539: 9 ST D18S51: 13 ST D19S433: 13 ST D1S1656: 13,17.3 ST D21S11: 31 ST D22S1045: 16,17 ST D2S1338: 17,25 ST D2S441: 11,14 ST D3S1358: 14,15 ST D5S818: 12 ST D6S1043: 11 ST D7S820: 9,12 ST D8S1179: 12,13 ST DYS391: 11 ST FGA: 21,26 (ATCC=CRL-2876; PubMed=25877200; Technion Genomics Center) ST FGA: 26 (CLS=300631) ST Penta D: 9 ST Penta E: 10,12 ST TH01: 9.3 ST TPOX: 8,11 ST vWA: 18,19 DI NCIt; C4863; Prostate carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) OI CVCL_2025 ! DuCaP SX Male AG 59Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 46 CH CVCL_A1BP ! VCaP AR-V7/pHag CH CVCL_A0BX ! VCaP-CR CH CVCL_RA58 ! VCaP-EnzR CH CVCL_C0QQ ! VCaP-R CH CVCL_WZ27 ! VCaP-SL // RX CelloPub=CLPUB00698; RA van Bokhoven, Adrie RT "Models for prostate cancer. Molecular characterization and critical RT appraisal of human prostate carcinoma cell lines."; RL Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands. // RX PubMed=23615946; DOI=10.1007/s00439-013-1308-1; RA Teles Alves, Ines RA Hiltemann, Saskia RA Hartjes, Thomas RA van der Spek, Peter J. RA Stubbs, Andrew RA Trapman, Jan RA Jenster, Guido RT "Gene fusions by chromothripsis of chromosome 5q in the VCaP prostate RT cancer cell line."; RL Hum. Genet. 132:709-713(2013). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=30244336; DOI=10.1007/s00345-018-2501-6; RA Samli, Hale RA Samli, Murat RA Vatansever, Buse RA Ardicli, Sena RA Aztopal, Nazlihan RA Dincel, Deniz RA Sahin, Ahmet RA Balci, Faruk RT "Paclitaxel resistance and the role of miRNAs in prostate cancer cell RT lines."; RL World J. Urol. 37:1117-1126(2019). // RX PubMed=23447416; DOI=10.1002/path.4186; PMCID=PMC3668093; RA Weier, Christopher RA Haffner, Michael C. RA Mosbruger, Timothy L. RA Esopi, David M. RA Hicks, Jessica L. RA Zheng, Qi-Zhi RA Fedor, Helen RA Isaacs, William B. RA De Marzo, Angelo M. RA Nelson, William George RA Yegnasubramanian, Srinivasan RT "Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in RT prostate cancer."; RL J. Pathol. 230:174-183(2013). // RX PubMed=29194687; DOI=10.1002/pros.23459; PMCID=PMC5768451; RA Fiandalo, Michael V. RA Wilton, John H. RA Mantione, Krystin M. RA Wrzosek, Carol RA Attwood, Kristopher M. RA Wu, Yue RA Mohler, James Larue RT "Serum-free complete medium, an alternative medium to mimic androgen RT deprivation in human prostate cancer cell line models."; RL Prostate 78:213-221(2018). // RX PubMed=21698104; DOI=10.1371/journal.pone.0020874; PMCID=PMC3117837; RA Sfanos, Karen Sandell RA Aloia, Amanda L. RA Hicks, Jessica L. RA Esopi, David M. RA Steranka, Jared P. RA Shao, Wei RA Sanchez-Martinez, Silvia RA Yegnasubramanian, Srinivasan RA Burns, Kathleen H. RA Rein, Alan RA De Marzo, Angelo M. RT "Identification of replication competent murine gammaretroviruses in RT commonly used prostate cancer cell lines."; RL PLoS ONE 6:e20874.1-e20874.6(2011). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=34402095; DOI=10.1002/pros.24210; PMCID=PMC8460612; RA Haffner, Michael C. RA Bhamidipati, Akshay RA Tsai, Harrison K. RA Esopi, David M. RA Vaghasia, Ajay M. RA Low, Jin-Yih RA Patel, Radhika A. RA Guner, Gunes RA Pham, Minh-Tam RA Castagna, Nicole RA Hicks, Jessica L. RA Wyhs, Nicolas RA Aebersold, Ruedi RA De Marzo, Angelo M. RA Nelson, William George RA Guo, Tian-Nan RA Yegnasubramanian, Srinivasan RT "Phenotypic characterization of two novel cell line models of RT castration-resistant prostate cancer."; RL Prostate 81:1159-1171(2021). // RX PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785; RA Yu, Katharine RA Chen, Bin RA Aran, Dvir RA Charalel, Joe RA Yau, Christina RA Wolf, Douglas M. RA van 't Veer, Laura J. RA Butte, Atul Janardhan RA Goldstein, Ted RA Sirota, Marina RT "Comprehensive transcriptomic analysis of cell lines as models of RT primary tumors across 22 tumor types."; RL Nat. Commun. 10:3574.1-3574.11(2019). // RX PubMed=23671654; DOI=10.1371/journal.pone.0063056; PMCID=PMC3646030; RA Lu, Yu-Heng RA Soong, T. David RA Elemento, Olivier RT "A novel approach for characterizing microsatellite instability in RT cancer cells."; RL PLoS ONE 8:e63056.1-e63056.10(2013). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin Karl RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=30305041; DOI=10.1186/s12885-018-4848-x; PMCID=PMC6180441; RA Jividen, Kasey RA Kedzierska, Katarzyna Z. RA Yang, Chun-Song RA Szlachta, Karol RA Ratan, Aakrosh RA Paschal, Bryce M. RT "Genomic analysis of DNA repair genes and androgen signaling in RT prostate cancer."; RL BMC Cancer 18:960.1-960.20(2018). // RX PubMed=14518030; DOI=10.1002/pros.10291; RA van Bokhoven, Adrie RA Caires, Aimee RA Di Maria, Michael RA Schulte, Aline Passarini RA Lucia, Marshall Scott RA Nordeen, Steven K. RA Miller, Gary J. RA Varella-Garcia, Marileila RT "Spectral karyotype (SKY) analysis of human prostate carcinoma cell RT lines."; RL Prostate 57:226-244(2003). // RX PubMed=14518029; DOI=10.1002/pros.10290; RA van Bokhoven, Adrie RA Varella-Garcia, Marileila RA Korch, Christopher T. RA Johannes, Widya U. RA Smith, E. Erin RA Miller, Heidi L. RA Nordeen, Steven K. RA Miller, Gary J. RA Lucia, Marshall Scott RT "Molecular characterization of human prostate carcinoma cell lines."; RL Prostate 57:205-225(2003). // RX PubMed=38892296; DOI=10.3390/ijms25116111; PMCID=PMC11172770; RA Beatson, Erica L. RA Risdon, Emily N. RA Napoli, Giulia C. RA Price, Douglas K. RA Chau, Cindy H. RA Figg, William Douglas Sr. RT "Genomic characterization of preclinical prostate cancer cell line RT models."; RL Int. J. Mol. Sci. 25:6111.1-6111.19(2024). // RX PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652; RA Cowley, Glenn S. RA Weir, Barbara A. RA Vazquez, Francisca RA Tamayo, Pablo RA Scott, Justine A. RA Rusin, Scott RA East-Seletsky, Alexandra RA Ali, Levi D. RA Gerath, William F.J. RA Pantel, Sarah E. RA Lizotte, Patrick Hall RA Jiang, Guo-Zhi RA Hsiao, Jessica RA Tsherniak, Aviad RA Dwinell, Elizabeth RA Aoyama, Simon RA Okamoto, Michael RA Harrington, William RA Gelfand, Ellen T. RA Green, Thomas M. RA Tomko, Mark J. RA Gopal, Shuba RA Wong, Terence C. RA Li, Hu-Bo RA Howell, Sara RA Stransky, Nicolas RA Liefeld, Ted RA Jang, Dongkeun RA Bistline, Jonathan RA Meyers, Barbara Hill RA Armstrong, Scott Allen RA Anderson, Kenneth Carl RA Stegmaier, Kimberly RA Reich, Michael RA Pellman, David RA Boehm, Jesse S. RA Mesirov, Jill P. RA Golub, Todd Robert RA Root, David E. RA Hahn, William Chun RT "Parallel genome-scale loss of function screens in 216 cancer cell RT lines for the identification of context-specific genetic RT dependencies."; RL Sci. Data 1:140035.1-140035.12(2014). // RX PubMed=11317522; RA Korenchuk, Susan RA Lehr, Jeffrey E. RA McLean, Lisa RA Lee, Young-Goo RA Whitney, Sarah RA Vessella, Robert Louis RA Lin, Din L. RA Pienta, Kenneth James RT "VCaP, a cell-based model system of human prostate cancer."; RL In Vivo 15:163-168(2001). // RX PubMed=28145883; DOI=10.18632/oncotarget.14850; PMCID=PMC5386661; RA Nouri, Mannan RA Caradec, Josselin RA Lubik, Amy Anne RA Li, Na RA Hollier, Brett G. RA Takhar, Mandeep RA Altimirano-Dimas, Manuel RA Chen, Meng-Qian RA Roshan-Moniri, Mani RA Butler, Miriam RA Lehman, Melanie RA Bishop, Jennifer L. RA Truong, Sarah RA Huang, Shih-Chieh RA Cochrane, Dawn R. RA Cox, Michael RA Collins, Catherine RA Gleave, Martin E. RA Erho, Nicholas RA Alshalafa, Mohamed RA Davicioni, Elai RA Nelson, Colleen C. RA Gregory-Evans, Cheryl Y. RA Karnes, R. Jeffrey RA Jenkins, Robert Brian RA Klein, Eric A. RA Buttyan, Ralph RT "Therapy-induced developmental reprogramming of prostate cancer cells RT and acquired therapy resistance."; RL Oncotarget 8:18949-18967(2017). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). //