ID   UPCI-SCC-099
AC   CVCL_2225
SY   UPCI:SCC099; SCC099
DR   BioSample; SAMN03473479
DR   cancercelllines; CVCL_2225
DR   DSMZ; ACC-665
DR   DSMZCellDive; ACC-665
DR   IARC_TP53; 18358
DR   Wikidata; Q54991660
RX   PubMed=12872257;
RX   PubMed=17112776;
RX   PubMed=17681875;
RX   PubMed=24142626;
CC   Doubling time: ~50 hours (DSMZ=ACC-665).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro177Arg (c.530C>G); ClinVar=VCV000458547; Zygosity=Unspecified (PubMed=12872257).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Caution: While the tumor has been shown to be HPV16 positive (PubMed=17112776), the cell line seems to be HPV16 negative (DSMZ=ACC-665).
CC   Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
ST   Source(s): DSMZ=ACC-665
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8,13
ST   D16S539: 11,12
ST   D18S51: 13
ST   D19S433: 14,16
ST   D21S11: 28
ST   D2S1338: 18
ST   D3S1358: 16
ST   D5S818: 11,12
ST   D7S820: 7,9,10
ST   D8S1179: 13
ST   FGA: 23,23.2
ST   Penta D: 9
ST   Penta E: 7,8
ST   TH01: 6,9.3
ST   TPOX: 11
ST   vWA: 14,18,19
DI   NCIt; C4041; Floor of mouth squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 21
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RX   PubMed=12872257; DOI=10.1002/humu.10248;
RA   Telmer C.A., An J.-Y., Malehorn D.E., Zeng X.-M., Gollin S.M.,
RA   Ishwad C.S., Jarvik J.W.;
RT   "Detection and assignment of TP53 mutations in tumor DNA using peptide
RT   mass signature genotyping.";
RL   Hum. Mutat. 22:158-165(2003).
//
RX   PubMed=17112776; DOI=10.1016/j.oraloncology.2006.09.001;
RA   White J.S., Weissfeld J.L., Ragin C.C.R., Rossie K.M., Martin C.L.,
RA   Shuster M., Ishwad C.S., Law J.C., Myers E.N., Johnson J.T.,
RA   Gollin S.M.;
RT   "The influence of clinical and demographic risk factors on the
RT   establishment of head and neck squamous cell carcinoma cell lines.";
RL   Oral Oncol. 43:701-712(2007).
//
RX   PubMed=17681875; DOI=10.1016/j.oraloncology.2007.05.003;
RA   Martin C.L., Reshmi S.C., Ried T., Gottberg W., Wilson J.W.,
RA   Reddy J.K., Khanna P., Johnson J.T., Myers E.N., Gollin S.M.;
RT   "Chromosomal imbalances in oral squamous cell carcinoma: examination
RT   of 31 cell lines and review of the literature.";
RL   Oral Oncol. 44:369-382(2008).
//
RX   PubMed=24142626; DOI=10.1002/gcc.22115;
RA   Parikh R.A., Appleman L.J., Bauman J.E., Sankunny M., Lewis D.W.,
RA   Vlad A., Gollin S.M.;
RT   "Upregulation of the ATR-CHEK1 pathway in oral squamous cell
RT   carcinomas.";
RL   Genes Chromosomes Cancer 53:25-37(2014).
//