ID   TC-71
AC   CVCL_2213
SY   TC71; GM11654
DR   BTO; BTO_0002604
DR   CLO; CLO_0009879
DR   CLO; CLO_0021329
DR   EFO; EFO_0002865
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   BioGRID_ORCS_Cell_line; 200
DR   BioSample; SAMN03473241
DR   BioSample; SAMN10987608
DR   cancercelllines; CVCL_2213
DR   Cell_Model_Passport; SIDM00419
DR   Coriell; GM11654
DR   Cosmic; 1078383
DR   Cosmic; 1082507
DR   Cosmic; 1112132
DR   Cosmic; 1718433
DR   Cosmic; 2228246
DR   Cosmic; 2250474
DR   Cosmic; 2294589
DR   Cosmic-CLP; 1240221
DR   DepMap; ACH-000424
DR   DSMZ; ACC-516
DR   DSMZCellDive; ACC-516
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 1240221
DR   GEO; GSM510013
DR   GEO; GSM887689
DR   GEO; GSM888781
DR   GEO; GSM1670525
DR   GEO; GSM1676323
DR   GEO; GSM1701656
DR   GEO; GSM4368464
DR   GEO; GSM5359718
DR   GEO; GSM5359719
DR   GEO; GSM5359720
DR   GEO; GSM5359721
DR   GEO; GSM5359722
DR   GEO; GSM5359723
DR   GEO; GSM5362946
DR   GEO; GSM5362947
DR   GEO; GSM5362954
DR   GEO; GSM5362956
DR   GEO; GSM5362963
DR   GEO; GSM5362964
DR   GEO; GSM5364016
DR   GEO; GSM5364017
DR   GEO; GSM5364018
DR   GEO; GSM5364019
DR   GEO; GSM5364020
DR   IARC_TP53; 15970
DR   IARC_TP53; 27040
DR   LiGeA; CCLE_900
DR   LINCS_LDP; LCL-1438
DR   PharmacoDB; TC71_1567_2019
DR   PRIDE; PXD012680
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_2213
DR   Wikidata; Q54971816
RX   DOI=10.5282/edoc.27750;
RX   PubMed=3004699;
RX   PubMed=3390826;
RX   PubMed=8040301;
RX   PubMed=8617485;
RX   PubMed=9823299;
RX   PubMed=11891184;
RX   PubMed=15150091;
RX   PubMed=18160777;
RX   PubMed=19787792;
RX   PubMed=20197622;
RX   PubMed=20922763;
RX   PubMed=21822310;
RX   PubMed=22142829;
RX   PubMed=22460905;
RX   PubMed=24312454;
RX   PubMed=25010205;
RX   PubMed=25223734;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25984343;
RX   PubMed=26351324;
RX   PubMed=26428435;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=29464090;
RX   PubMed=30879952;
RX   PubMed=30894373;
RX   PubMed=30962207;
RX   PubMed=30971826;
RX   PubMed=31068700;
RX   PubMed=31978347;
RX   PubMed=35839778;
RX   PubMed=36476851;
WW   Info; ESCLA; -; https://hgserver1.amc.nl/cgi-bin/r2/main.cgi?option=about_dscope
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
WW   Provider; CCR; -; https://www.cccells.org/PDF_Files/Ewings/TC-71.pdf
WW   Provider; CCR; -; https://www.cccells.org/tables/Ewings.php
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: Ewing Sarcoma Cell Line Atlas (ESCLA).
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
CC   Population: Caucasian.
CC   Doubling time: 15 hours (PubMed=20922763); 21 hours (PubMed=24312454); 26 hours (PubMed=25984343); ~24 hours (DSMZ=ACC-516).
CC   HLA typing: A*02:01,68:01; B*15:07,44:02; C*03:03,05:01 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=18160777; PubMed=19787792; PubMed=25010205; PubMed=25223734).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3508; EWSR1 + HGNC; HGNC:3749; FLI1; Name(s)=EWSR1-FLI1, EWS-FLI1; Note=Type 1 fusion (Ex7/Ex6) (PubMed=8040301; PubMed=11891184; PubMed=25010205; PubMed=25485619; PubMed=36476851).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg213Ter (c.637C>T); ClinVar=VCV000043590; Zygosity=Unspecified (PubMed=19787792; PubMed=25010205; PubMed=25223734; DepMap=ACH-000424).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Cys (c.733G>T); ClinVar=VCV000012349; Zygosity=Unspecified (PubMed=25010205).
CC   Omics: Genomics; ChIP-seq; FLI1.
CC   Omics: Genomics; ChIP-seq; H3K27ac.
CC   Omics: Genomics; ChIP-seq; H3K27me3.
CC   Omics: Genomics; ChIP-seq; H3K4me3.
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Genomics; Whole genome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Phenotyping; shRNA library screening.
CC   Omics: Proteomics.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Transcriptomics; RNAseq; Single cell.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.1%; Native American=0.12%; East Asian, North=1.75%; East Asian, South=0%; South Asian=0.97%; European, North=65.4%; European, South=31.66% (PubMed=30894373).
CC   Derived from site: In situ; Bone, humerus; UBERON=UBERON_0000976.
ST   Source(s): COG; Cosmic-CLP=1240221; DSMZ=ACC-516; PubMed=19787792; PubMed=20922763; PubMed=24312454; PubMed=25010205; PubMed=25877200; PubMed=30879952
ST   Amelogenin: X (PubMed=25877200)
ST   Amelogenin: X,Y (COG; Cosmic-CLP=1240221; DSMZ=ACC-516; PubMed=19787792; PubMed=20922763; PubMed=24312454; PubMed=25010205; PubMed=30879952)
ST   CSF1PO: 10 (PubMed=25010205)
ST   CSF1PO: 10,11 (COG; Cosmic-CLP=1240221; DSMZ=ACC-516; PubMed=20922763; PubMed=24312454; PubMed=30879952)
ST   D13S317: 11,12
ST   D16S539: 11,14
ST   D18S51: 12,15
ST   D19S433: 14 (DSMZ=ACC-516; PubMed=19787792; PubMed=25010205)
ST   D19S433: 14,16.2 (PubMed=24312454)
ST   D21S11: 29,30
ST   D2S1338: 20,24
ST   D3S1358: 15,17
ST   D5S818: 10
ST   D7S820: 10
ST   D8S1179: 10 (DSMZ=ACC-516; PubMed=19787792)
ST   D8S1179: 10,12 (PubMed=20922763; PubMed=24312454; PubMed=25010205; PubMed=25877200)
ST   FGA: 24,26
ST   Penta D: 11,14
ST   Penta E: 12
ST   SE33: 21,30.2
ST   TH01: 9.3
ST   TPOX: 8,9
ST   vWA: 17 (COG; DSMZ=ACC-516; PubMed=20922763; PubMed=24312454; PubMed=25010205; PubMed=25877200)
ST   vWA: 17,18 (PubMed=19787792; PubMed=30879952)
ST   vWA: 17,19 (Cosmic-CLP=1240221)
DI   NCIt; C4817; Ewing sarcoma
DI   ORDO; Orphanet_319; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   22Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 46
//
RX   DOI=10.5282/edoc.27750;
RA   Orth, Martin Franz
RT   "Systematic multi-omics profiling of Ewing sarcoma cell lines.";
RL   Thesis PhD (2021); Ludwig Maximilians University of Munich; Munich; Germany.
//
RX   PubMed=3004699; DOI=10.1016/0165-4608(86)90001-4;
RA   Whang-Peng, Jacqueline
RA   Triche, Timothy J.
RA   Knutsen, Turid
RA   Miser, James S.
RA   Kao-Shan, Chien-Song
RA   Tsai, Schickwann
RA   Israel, Mark A.
RT   "Cytogenetic characterization of selected small round cell tumors of
RT   childhood.";
RL   Cancer Genet. Cytogenet. 21:185-208(1986).
//
RX   PubMed=3390826;
RA   McKeon, Catherine
RA   Thiele, Carol Jeanne
RA   Ross, Robert A.
RA   Kwan, Michael
RA   Triche, Timothy J.
RA   Miser, James S.
RA   Israel, Mark A.
RT   "Indistinguishable patterns of protooncogene expression in two
RT   distinct but closely related tumors: Ewing's sarcoma and
RT   neuroepithelioma.";
RL   Cancer Res. 48:4307-4311(1988).
//
RX   PubMed=8040301; DOI=10.1172/JCI117360; PMCID=PMC295111;
RA   Giovannini, Marco
RA   Biegel, Jaclyn A.
RA   Serra, Massimo
RA   Wang, Jian-Ying
RA   Wei, Ya-Lin H.
RA   Nycum, Lynn M.
RA   Emanuel, Beverly S.
RA   Evans, Glen A.
RT   "EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and
RT   primitive neuroectodermal tumors with variant translocations.";
RL   J. Clin. Invest. 94:489-496(1994).
//
RX   PubMed=8617485; DOI=10.1016/S0046-8177(96)90115-X;
RA   Scotlandi, Katia
RA   Serra, Massimo
RA   Manara, Maria Cristina
RA   Benini, Stefania
RA   Sarti, Manuela
RA   Maurici, Daniela
RA   Lollini, Pier-Luigi
RA   Picci, Piero
RA   Bertoni, Francesco
RA   Baldini, Nicola
RT   "Immunostaining of the p30/32MIC2 antigen and molecular detection of
RT   EWS rearrangements for the diagnosis of Ewing's sarcoma and peripheral
RT   neuroectodermal tumor.";
RL   Hum. Pathol. 27:408-416(1996).
//
RX   PubMed=9823299;
RA   Khan, Javed
RA   Simon, Richard M.
RA   Bittner, Michael
RA   Chen, Yi-Dong
RA   Leighton, Stephen B.
RA   Pohida, Thomas
RA   Smith, Paul D.
RA   Jiang, Yuan
RA   Gooden, Gerald C.
RA   Trent, Jeffrey M.
RA   Meltzer, Paul S.
RT   "Gene expression profiling of alveolar rhabdomyosarcoma with cDNA
RT   microarrays.";
RL   Cancer Res. 58:5009-5013(1998).
//
RX   PubMed=11891184; DOI=10.1016/S0002-9440(10)64908-5; PMCID=PMC1867180;
RA   Manara, Maria Cristina
RA   Perbal, Bernard
RA   Benini, Stefania
RA   Strammiello, Rosaria
RA   Cerisano, Vanessa
RA   Perdichizzi, Stefania
RA   Serra, Massimo
RA   Astolfi, Annalisa
RA   Bertoni, Francesco
RA   Alami, Jennifer
RA   Yeger, Herman
RA   Picci, Piero
RA   Scotlandi, Katia
RT   "The expression of ccn3(nov) gene in musculoskeletal tumors.";
RL   Am. J. Pathol. 160:849-859(2002).
//
RX   PubMed=15150091; DOI=10.1158/0008-5472.CAN-03-0809;
RA   Schaefer, Karl-Ludwig
RA   Brachwitz, Kristin
RA   Wai, Daniel H.
RA   Braun, Yvonne
RA   Diallo, Raihanatou
RA   Korsching, Eberhard
RA   Eisenacher, Martin
RA   Voss, Reinhard
RA   van Valen, Frans
RA   Baer, Claudia
RA   Selle, Barbara
RA   Spahn, Laura
RA   Liao, Shuen-Kuei
RA   Lee, Kevin A.W.
RA   Hogendoorn, Pancras Cornelis Wilhelmus
RA   Reifenberger, Guido
RA   Gabbert, Helmut Erich
RA   Poremba, Christopher
RT   "Expression profiling of t(12;22) positive clear cell sarcoma of soft
RT   tissue cell lines reveals characteristic up-regulation of potential
RT   new marker genes including ERBB3.";
RL   Cancer Res. 64:3395-3405(2004).
//
RX   PubMed=18160777; DOI=10.1159/000109614;
RA   Savola, Suvi
RA   Nardi, Filippo
RA   Scotlandi, Katia
RA   Picci, Piero
RA   Knuutila, Sakari
RT   "Microdeletions in 9p21.3 induce false negative results in CDKN2A FISH
RT   analysis of Ewing sarcoma.";
RL   Cytogenet. Genome Res. 119:21-26(2007).
//
RX   PubMed=19787792; DOI=10.1002/gcc.20717;
RA   Ottaviano, Laura
RA   Schaefer, Karl-Ludwig
RA   Gajewski, Melanie
RA   Huckenbeck, Wolfgang
RA   Baldus, Stefan E.
RA   Rogel, Uwe
RA   Mackintosh, Carlos
RA   de Alava, Enrique
RA   Myklebost, Ola
RA   Kresse, Stine Henrichson
RA   Meza-Zepeda, Leonardo Andres
RA   Serra, Massimo
RA   Cleton-Jansen, Anne-Marie
RA   Hogendoorn, Pancras Cornelis Wilhelmus
RA   Buerger, Horst
RA   Aigner, Thomas
RA   Gabbert, Helmut Erich
RA   Poremba, Christopher
RT   "Molecular characterization of commonly used cell lines for bone tumor
RT   research: a trans-European EuroBoNet effort.";
RL   Genes Chromosomes Cancer 49:40-51(2010).
//
RX   PubMed=20197622; DOI=10.1172/JCI36667; PMCID=PMC2827943;
RA   Rocchi, Anna
RA   Manara, Maria Cristina
RA   Sciandra, Marika
RA   Zambelli, Diana
RA   Nardi, Filippo
RA   Nicoletti, Giordano
RA   Garofalo, Cecilia
RA   Meschini, Stefania
RA   Astolfi, Annalisa
RA   Colombo, Mario P.
RA   Lessnick, Stephen Lee
RA   Picci, Piero
RA   Scotlandi, Katia
RT   "CD99 inhibits neural differentiation of human Ewing sarcoma cells and
RT   thereby contributes to oncogenesis.";
RL   J. Clin. Invest. 120:668-680(2010).
//
RX   PubMed=20922763; DOI=10.1002/pbc.22801; PMCID=PMC3005554;
RA   Kang, Min H.
RA   Smith, Malcolm A.
RA   Morton, Christopher L.
RA   Keshelava, Nino
RA   Houghton, Peter J.
RA   Reynolds, Charles Patrick
RT   "National Cancer Institute pediatric preclinical testing program:
RT   model description for in vitro cytotoxicity testing.";
RL   Pediatr. Blood Cancer 56:239-249(2011).
//
RX   PubMed=21822310; DOI=10.1038/onc.2011.317;
RA   Mackintosh, Carlos
RA   Ordonez, Jose L.
RA   Garcia-Dominguez, Daniel J.
RA   Sevillano, Vicky
RA   Llombart-Bosch, Antonio
RA   Szuhai, Karoly
RA   Scotlandi, Katia
RA   Alberghini, Marco
RA   Sciot, Raf
RA   Sinnaeve, Friedl
RA   Hogendoorn, Pancras Cornelis Wilhelmus
RA   Picci, Piero
RA   Knuutila, Sakari
RA   Dirksen, Uta
RA   Debiec-Rychter, Maria
RA   Schaefer, Karl-Ludwig
RA   de Alava, Enrique
RT   "1q gain and CDT2 overexpression underlie an aggressive and highly
RT   proliferative form of Ewing sarcoma.";
RL   Oncogene 31:1287-1298(2012).
//
RX   PubMed=22142829; DOI=10.1158/1078-0432.CCR-11-2056; PMCID=PMC3271129;
RA   Shukla, Neerav
RA   Ameur, Nabahet
RA   Yilmaz, Ismail
RA   Nafa, Khedoudja
RA   Lau, Chyau-Yueh
RA   Marchetti, Angela
RA   Borsu, Laetitia
RA   Barr, Frederic G.
RA   Ladanyi, Marc
RT   "Oncogene mutation profiling of pediatric solid tumors reveals
RT   significant subsets of embryonal rhabdomyosarcoma and neuroblastoma
RT   with mutated genes in growth signaling pathways.";
RL   Clin. Cancer Res. 18:748-757(2012).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura E.
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=24312454; DOI=10.1371/journal.pone.0080060; PMCID=PMC3846563;
RA   May, William A.
RA   Grigoryan, Rita S.
RA   Keshelava, Nino
RA   Cabral, Daniel J.
RA   Christensen, Laura L.
RA   Jenabi, Jasmine
RA   Ji, Ling-Yun
RA   Triche, Timothy J.
RA   Lawlor, Elizabeth R.
RA   Reynolds, Charles Patrick
RT   "Characterization and drug resistance patterns of Ewing's sarcoma
RT   family tumor cell lines.";
RL   PLoS ONE 8:e80060.1-e80060.10(2013).
//
RX   PubMed=25010205; DOI=10.1371/journal.pgen.1004475; PMCID=PMC4091782;
RA   Brohl, Andrew S.
RA   Solomon, David A.
RA   Chang, Wendy
RA   Wang, Jian-Jun
RA   Song, Young
RA   Sindiri, Sivasish
RA   Patidar, Rajesh
RA   Hurd, Laura
RA   Chen, Li
RA   Shern, Jack F.
RA   Liao, Hong-Ling
RA   Wen, Xin-Yu
RA   Gerard, Julia
RA   Kim, Jung-Sik
RA   Lopez Guerrero, Jose Antonio
RA   Machado, Isidro
RA   Wai, Daniel H.
RA   Picci, Piero
RA   Triche, Timothy J.
RA   Horvai, Andrew E.
RA   Miettinen, Markku Martti
RA   Wei, Jun S.
RA   Catchpoole, Daniel
RA   Llombart-Bosch, Antonio
RA   Waldman, Todd A.
RA   Khan, Javed
RT   "The genomic landscape of the Ewing sarcoma family of tumors reveals
RT   recurrent STAG2 mutation.";
RL   PLoS Genet. 10:e1004475.1-e1004475.13(2014).
//
RX   PubMed=25223734; DOI=10.1158/2159-8290.CD-14-0622; PMCID=PMC4264969;
RA   Tirode, Franck
RA   Surdez, Didier
RA   Ma, Xiao-Tu
RA   Parker, Matthew
RA   Le Deley, Marie-Cecile
RA   Bahrami, Armita
RA   Zhang, Zhao-Jie
RA   Lapouble, Eve
RA   Grossetete-Lalami, Sandrine
RA   Rusch, Michael
RA   Reynaud, Stephanie
RA   Rio-Frio, Thomas
RA   Hedlund, Erin
RA   Wu, Gang
RA   Chen, Xiang
RA   Pierron, Gaelle
RA   Oberlin, Odile
RA   Zaidi, Sakina
RA   Lemmon, Gordon
RA   Gupta, Pankaj
RA   Vadodaria, Bhavin
RA   Easton, John
RA   Gut, Marta
RA   Ding, Li
RA   Mardis, Elaine R.
RA   Wilson, Richard K.
RA   Shurtleff, Sheila
RA   Laurence, Valerie
RA   Michon, Jean
RA   Marec-Berard, Perrine
RA   Gut, Ivo G.
RA   Downing, James R.
RA   Dyer, Michael Anthony
RA   Zhang, Jing-Hui
RA   Delattre, Olivier
RG   International Cancer Genome Consortium;
RG   St. Jude Children's Research Hospital-Washington University Pediatric Cancer Genome Project;
RT   "Genomic landscape of Ewing sarcoma defines an aggressive subtype with
RT   co-association of STAG2 and TP53 mutations.";
RL   Cancer Discov. 4:1342-1353(2014).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652;
RA   Cowley, Glenn S.
RA   Weir, Barbara A.
RA   Vazquez, Francisca
RA   Tamayo, Pablo
RA   Scott, Justine A.
RA   Rusin, Scott
RA   East-Seletsky, Alexandra
RA   Ali, Levi D.
RA   Gerath, William F.J.
RA   Pantel, Sarah E.
RA   Lizotte, Patrick Hall
RA   Jiang, Guo-Zhi
RA   Hsiao, Jessica
RA   Tsherniak, Aviad
RA   Dwinell, Elizabeth
RA   Aoyama, Simon
RA   Okamoto, Michael
RA   Harrington, William
RA   Gelfand, Ellen T.
RA   Green, Thomas M.
RA   Tomko, Mark J.
RA   Gopal, Shuba
RA   Wong, Terence C.
RA   Li, Hu-Bo
RA   Howell, Sara
RA   Stransky, Nicolas
RA   Liefeld, Ted
RA   Jang, Dongkeun
RA   Bistline, Jonathan
RA   Meyers, Barbara Hill
RA   Armstrong, Scott Allen
RA   Anderson, Kenneth Carl
RA   Stegmaier, Kimberly
RA   Reich, Michael
RA   Pellman, David
RA   Boehm, Jesse S.
RA   Mesirov, Jill P.
RA   Golub, Todd Robert
RA   Root, David E.
RA   Hahn, William Chun
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035.1-140035.12(2014).
//
RX   PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476;
RA   Teicher, Beverly A.
RA   Polley, Eric C.
RA   Kunkel, Mark W.
RA   Evans, David
RA   Silvers, Thomas E.
RA   Delosh, Rene M.
RA   Laudeman, Julie
RA   Ogle, Chad
RA   Reinhart, Russell
RA   Selby, Michael
RA   Connelly, John
RA   Harris, Erik
RA   Monks, Anne
RA   Morris, Joel
RT   "Sarcoma cell line screen of oncology drugs and investigational agents
RT   identifies patterns associated with gene and microRNA expression.";
RL   Mol. Cancer Ther. 14:2452-2462(2015).
//
RX   PubMed=26428435; DOI=10.1016/j.ejca.2015.08.020;
RA   Sand, Laurens G.L.
RA   Scotlandi, Katia
RA   Berghuis, Dagmar
RA   Snaar-Jagalska, B. Ewa
RA   Picci, Piero
RA   Schmidt, Thomas
RA   Szuhai, Karoly
RA   Hogendoorn, Pancras Cornelis Wilhelmus
RT   "CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate
RT   with survival and metastases in Ewing sarcoma patients.";
RL   Eur. J. Cancer 51:2624-2633(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, A. Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29464090; DOI=10.18632/oncotarget.23815; PMCID=PMC5814230;
RA   Spurny, Christian
RA   Kailayangiri, Sareetha
RA   Altvater, Bianca
RA   Jamitzky, Silke
RA   Hartmann, Wolfgang
RA   Wardelmann, Eva
RA   Ranft, Andreas
RA   Dirksen, Uta
RA   Amler, Susanne
RA   Hardes, Jendrik
RA   Fluegge, Maike
RA   Meltzer, Jutta
RA   Farwick, Nicole
RA   Greune, Lea
RA   Rossig, Claudia
RT   "T cell infiltration into Ewing sarcomas is associated with local
RT   expression of immune-inhibitory HLA-G.";
RL   Oncotarget 9:6536-6549(2018).
//
RX   PubMed=30879952; DOI=10.1016/j.ymthe.2019.02.014; PMCID=PMC6520468;
RA   Kailayangiri, Sareetha
RA   Altvater, Bianca
RA   Lesch, Stefanie
RA   Balbach, Sebastian T.
RA   Gottlich, Claudia
RA   Kuhnemundt, Johanna
RA   Mikesch, Jan-Henrik
RA   Schelhaas, Sonja
RA   Jamitzky, Silke
RA   Meltzer, Jutta
RA   Farwick, Nicole
RA   Greune, Lea
RA   Fluegge, Maike
RA   Kerl, Kornelius
RA   Lode, Holger N.
RA   Siebert, Nikolai
RA   Muller, Ingo
RA   Walles, Heike
RA   Hartmann, Wolfgang
RA   Rossig, Claudia
RT   "EZH2 inhibition in Ewing sarcoma upregulates GD2 expression for
RT   targeting with gene-modified T cells.";
RL   Mol. Ther. 27:933-946(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=30962207; DOI=10.15252/embr.201845766; PMCID=PMC6500973;
RA   Linden, Malin
RA   Thomsen, Christer
RA   Grundevik, Pernilla
RA   Jonasson, Emma
RA   Andersson, Daniel
RA   Runnberg, Rikard
RA   Dolatabadi, Soheila
RA   Vannas, Christoffer
RA   Santamaria, Manuel Luna
RA   Fagman, Henrik
RA   Stahlberg, Anders
RA   Aman, Pierre
RT   "FET family fusion oncoproteins target the SWI/SNF chromatin
RT   remodeling complex.";
RL   EMBO Rep. 20:e45766.1-e45766.15(2019).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254;
RA   Nusinow, David Paul
RA   Szpyt, John
RA   Ghandi, Mahmoud
RA   Rose, Christopher M.
RA   McDonald, E. Robert 3rd
RA   Kalocsay, Marian
RA   Jane-Valbuena, Judit
RA   Gelfand, Ellen T.
RA   Schweppe, Devin K.
RA   Jedrychowski, Mark P.
RA   Golji, Javad
RA   Porter, Dale A.
RA   Rejtar, Tomas
RA   Wang, Y. Karen
RA   Kryukov, Gregory V.
RA   Stegmeier, Frank
RA   Erickson, Brian K.
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RA   Gygi, Steven P.
RT   "Quantitative proteomics of the Cancer Cell Line Encyclopedia.";
RL   Cell 180:387-402.e16(2020).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=36476851; DOI=10.1016/j.celrep.2022.111761; PMCID=PMC10333306;
RA   Orth, Martin Franz
RA   Surdez, Didier
RA   Faehling, Tobias
RA   Ehlers, Anna C.
RA   Marchetto, Aruna
RA   Grossetete-Lalami, Sandrine
RA   Volckmann, Richard
RA   Zwijnenburg, Danny A.
RA   Gerke, Julia Sophie
RA   Zaidi, Sakina
RA   Alonso, Javier
RA   Sastre, Ana
RA   Baulande, Sylvain
RA   Sill, Martin
RA   Cidre-Aranaz, Florencia
RA   Ohmura, Shunya
RA   Kirchner, Thomas
RA   Hauck, Stefanie M.
RA   Reischl, Eva
RA   Gymrek, Melissa
RA   Pfister, Stefan Michael
RA   Strauch, Konstantin
RA   Koster, Jan
RA   Delattre, Olivier
RA   Grunewald, Thomas Georg Philipp
RT   "Systematic multi-omics cell line profiling uncovers principles of
RT   Ewing sarcoma fusion oncogene-mediated gene regulation.";
RL   Cell Rep. 41:111761.1-111761.28(2022).
//