ID   SKW-3
AC   CVCL_2197
SY   SKW3
DR   BTO; BTO_0006057
DR   CLO; CLO_0009068
DR   CLO; CLO_0051007
DR   CLDB; cl4362
DR   BioSample; SAMN03151818
DR   BioSample; SAMN03473523
DR   cancercelllines; CVCL_2197
DR   CLS; 300343
DR   Cosmic; 913412
DR   Cosmic; 919156
DR   Cosmic; 933546
DR   Cosmic; 1524820
DR   Cosmic; 1641385
DR   DSMZ; ACC-53
DR   DSMZCellDive; ACC-53
DR   FANTOM5_SSTAR; 10416-106C2
DR   NCBI_Iran; C182
DR   RCB; RCB1168
DR   TKG; TKG 0247
DR   Wikidata; Q108821313
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2985879;
RX   PubMed=3159941;
RX   PubMed=3874327;
RX   PubMed=7849311;
RX   PubMed=8127147;
RX   PubMed=8641406;
RX   PubMed=9510473;
RX   PubMed=9933131;
RX   PubMed=15472075;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
WW   Info; T-ALL cell lines db; -; https://humantallcelllines.wordpress.com/comprehensivetable/skw-3-ke-37/
CC   Problematic cell line: Contaminated. Shown to be a KE-37 derivative (PubMed=20143388). Originally thought to originate from the peripheral blood of a 61 year old male patient with T cell chronic lymphocytic leukemia.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00346.
CC   Population: Caucasian.
CC   Doubling time: ~30-40 hours (DSMZ=ACC-53); ~30 hours (CLS=300343).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Gln2459Ter (c.7375C>T); Zygosity=Heterozygous (PubMed=15472075).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg571Gln (c.1712G>A); ClinVar=VCV000819886; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Gly310Glu (c.929G>A); ClinVar=VCV000237678; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro153Alafs*28 (c.455dupC) (c.455_456insC) (p.P152fs) (c.459_460insC); ClinVar=VCV000182958; Zygosity=Heterozygous (from parent cell line).
ST   Source(s): CLS=300343; DSMZ=ACC-53; RCB=RCB1168; TKG=TKG 0247
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D12S391: 19,22
ST   D13S317: 8,12
ST   D16S539: 11,12
ST   D18S51: 13,18
ST   D19S433: 13,15
ST   D1S1656: 15.3,16
ST   D21S11: 28,29,30 (CLS=300343)
ST   D21S11: 28,30 (DSMZ=ACC-53)
ST   D2S1338: 19,25
ST   D3S1358: 15,18
ST   D5S818: 12,13
ST   D6S1043: 18,21
ST   D7S820: 8,12
ST   D8S1179: 11,14
ST   FGA: 24,25
ST   Penta D: 11,15
ST   Penta E: 5,14
ST   TH01: 6,9.3
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1327 ! KE-37
SX   Male
AG   27Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 33
CH   CVCL_J125 ! SK-beta2.7
CH   CVCL_4V58 ! SKW3/Clo
//
RX   PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- III.
RT   Beta-hexosaminidase (E.C. 3.2.1.30).";
RL   Leuk. Res. 9:549-559(1985).
//
RX   PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x;
RA   Borgonovo-Brandter, Laura
RA   Heyman, Mats
RA   Rasool, Omid
RA   Liu, Yie
RA   Grander, Dan
RA   Einhorn, Stefan
RT   "p16INK4/p15INK4B gene inactivation is a frequent event in malignant
RT   T-cell lines.";
RL   Eur. J. Haematol. 56:313-318(1996).
//
RX   PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893;
RA   Stranks, Gail
RA   Height, Susan E.
RA   Mitchell, Paul
RA   Jadayel, Dalal Mouneimne
RA   Yuille, Martin A.R.
RA   De Lord, Corinne F.M.
RA   Clutterbuck, Robyn D.
RA   Treleaven, Jennie G.
RA   Powles, Ray Leonard
RA   Nacheva, Elisabeth
RA   Oscier, David G.
RA   Karpas, Abraham
RA   Lenoir, Gilbert Marcel
RA   Smith, Stephen D.
RA   Millar, John L.
RA   Catovsky, Daniel
RA   Dyer, Martin John Swinnerton
RT   "Deletions and rearrangement of CDKN2 in lymphoid malignancy.";
RL   Blood 85:893-901(1995).
//
RX   PubMed=9933131; DOI=10.1016/S0145-2126(98)00133-7;
RA   Burger, Renate
RA   Hansen-Hagge, Thomas E.
RA   Drexler, Hans Gunther
RA   Gramatzki, Martin
RT   "Heterogeneity of T-acute lymphoblastic leukemia (T-ALL) cell lines:
RT   suggestion for classification by immunophenotype and T-cell receptor
RT   studies.";
RL   Leuk. Res. 23:19-27(1999).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=15472075; DOI=10.1126/science.1102160;
RA   Weng, Andrew P.
RA   Ferrando, Adolfo A.
RA   Lee, Woojoong
RA   Morris, John P. 4th
RA   Silverman, Lewis B.
RA   Sanchez-Irizarry, Cheryll
RA   Blacklow, Stephen Charles
RA   Look, Alfred Thomas
RA   Aster, Jon Christopher
RT   "Activating mutations of NOTCH1 in human T cell acute lymphoblastic
RT   leukemia.";
RL   Science 306:269-271(2004).
//
RX   PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588;
RA   Hosoya, Noriko
RA   Hangaishi, Akira
RA   Ogawa, Seishi
RA   Miyagawa, Kiyoshi
RA   Mitani, Kinuko
RA   Yazaki, Yoshio
RA   Hirai, Hisamaru
RT   "Frameshift mutations of the hMSH6 gene in human leukemia cell
RT   lines.";
RL   Jpn. J. Cancer Res. 89:33-39(1998).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1.
RT   Carboxylic esterase.";
RL   Leuk. Res. 9:209-229(1985).
//
RX   PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid
RT   phosphatase.";
RL   Leuk. Res. 9:537-548(1985).
//
RX   PubMed=8127147;
RA   Heyman, Mats
RA   Grander, Dan
RA   Brondum-Nielsen, Karen
RA   Cederblad, Britta
RA   Liu, Yie
RA   Xu, Bo
RA   Einhorn, Stefan
RT   "Interferon system defects in malignant T-cells.";
RL   Leukemia 8:425-434(1994).
//