ID   SKNO-1
AC   CVCL_2196
SY   Skno-1; SKNO1
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   BioSample; SAMN03473440
DR   BioSample; SAMN10989585
DR   cancercelllines; CVCL_2196
DR   Cell_Model_Passport; SIDM01864
DR   Cosmic; 787478
DR   Cosmic; 975301
DR   Cosmic; 1149337
DR   Cosmic; 1281353
DR   Cosmic; 1524841
DR   Cosmic; 2306239
DR   Cosmic; 2690678
DR   DepMap; ACH-001656
DR   DSMZ; ACC-690
DR   DSMZCellDive; ACC-690
DR   GEO; GSM236805
DR   GEO; GSM236841
DR   IARC_TP53; 16154
DR   JCRB; JCRB1170
DR   Wikidata; Q54954758
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=7772516;
RX   PubMed=9738977;
RX   PubMed=10637496;
RX   PubMed=11753612;
RX   PubMed=15843827;
RX   PubMed=18385756;
RX   PubMed=25984343;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31160637;
RX   PubMed=36982453;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: LL-100 blood cancer cell line panel.
CC   Population: Japanese.
CC   Characteristics: CSF2 dependent.
CC   Doubling time: 48-72 hours (PubMed=7772516); 24 hours (PubMed=25984343); ~35-50 hours (DSMZ=ACC-690); ~38 hours (Note=Lot 06112012), 52-57 hours (Note=Lot 02032016) (JCRB=JCRB1170).
CC   HLA typing: A*02:06:01,31:01:02; B*40:02:01,46:01:01; C*01:02:01,03:04:01; DRA*01:01:01,01:02:02; DRB1*14:02:01,14:02:01 (DSMZCellDive=ACC-690).
CC   Sequence variation: Gene fusion; HGNC; HGNC:10471; RUNX1 + HGNC; HGNC:1535; RUNX1T1; Name(s)=RUNX1-RUNX1T1, AML1-ETO (PubMed=11753612; PubMed=15843827).
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Asn822Lys (c.2466T>A) (N818K); ClinVar=VCV000375931; Zygosity=Homozygous (PubMed=18385756; DepMap=ACH-001656).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (PubMed=7772516; DepMap=ACH-001656).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.His368Arg (c.1103G>A); Zygosity=Homozygous (PubMed=7772516; DepMap=ACH-001656).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; shRNA library screening.
CC   Omics: Transcriptomics; RNAseq.
CC   Genome ancestry: African=1.83%; Native American=0%; East Asian, North=90.65%; East Asian, South=3.5%; South Asian=1.23%; European, North=0.2%; European, South=2.59% (PubMed=30894373).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): DSMZ=ACC-690; JCRB=JCRB1170
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D13S317: 8,11
ST   D16S539: 10,11
ST   D18S51: 13,14
ST   D19S433: 13,15
ST   D21S11: 29,30
ST   D2S1338: 19
ST   D3S1358: 16
ST   D5S818: 10,13
ST   D7S820: 10,12
ST   D8S1179: 14,15
ST   FGA: 23
ST   Penta D: 9
ST   Penta E: 11,12
ST   TH01: 7
ST   TPOX: 8,9
ST   vWA: 14,17
DI   NCIt; C7961; Adult acute myeloid leukemia with maturation
DI   ORDO; Orphanet_98834; Acute myeloblastic leukemia with maturation
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   22Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 14-08-25; Version: 33
//
RX   PubMed=15843827; DOI=10.1038/sj.leu.2403749;
RA   Hagstrom-Andersson, Anna K.
RA   Eden, Patrik
RA   Lindgren, David
RA   Nilsson, Jens
RA   Lassen, Carin
RA   Heldrup, Jesper
RA   Fontes, Magnus
RA   Borg, Ake
RA   Mitelman, Felix
RA   Johansson, Bertil
RA   Hoglund, Mattias
RA   Fioretos, Thoas
RT   "Gene expression profiling of leukemic cell lines reveals conserved
RT   molecular signatures among subtypes with specific genetic
RT   aberrations.";
RL   Leukemia 19:1042-1050(2005).
//
RX   PubMed=18385756; DOI=10.1038/leu.2008.61;
RA   Becker, Heiko
RA   Pfeifer, Dietmar
RA   Duque-Afonso, Jesus
RA   Nimer, Stephen D.
RA   Veelken, Hendrik
RA   Schwabe, Michael
RA   Lubbert, Michael
RT   "Two cell lines of t(8;21) acute myeloid leukemia with activating KIT
RT   exon 17 mutation: models for the 'second hit' hypothesis.";
RL   Leukemia 22:1792-1794(2008).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=10637496; DOI=10.1038/sj.leu.2401604;
RA   Drexler, Hans Gunther
RA   Fombonne, Severine
RA   Matsuo, Yoshinobu
RA   Hu, Zhen-Bo
RA   Hamaguchi, Hiroyuki
RA   Uphoff, Cord C.
RT   "p53 alterations in human leukemia-lymphoma cell lines: in
RT   vitro artifact or prerequisite for cell immortalization?";
RL   Leukemia 14:198-206(2000).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=7772516; DOI=10.1111/j.1365-2141.1995.tb08418.x;
RA   Matozaki, Sachiko
RA   Nakagawa, Toshitaro
RA   Kawaguchi, Ryuji
RA   Aozaki, Riyoji
RA   Tsutsumi, Masayoshi
RA   Murayama, Tohru
RA   Koizumi, Tamio
RA   Nishimura, Ryuichiro
RA   Isobe, Takashi
RA   Chihara, Kazuo
RT   "Establishment of a myeloid leukaemic cell line (SKNO-1) from a
RT   patient with t(8;21) who acquired monosomy 17 during disease
RT   progression.";
RL   Br. J. Haematol. 89:805-811(1995).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646;
RA   Quentmeier, Hilmar
RA   Pommerenke, Claudia
RA   Dirks, Wilhelm Gerhard
RA   Eberth, Sonja
RA   Koeppel, Max
RA   MacLeod, Roderick A.F.
RA   Nagel, Stefan
RA   Steube, Klaus G.
RA   Uphoff, Cord C.
RA   Drexler, Hans Gunther
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218.1-8218.14(2019).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652;
RA   Cowley, Glenn S.
RA   Weir, Barbara A.
RA   Vazquez, Francisca
RA   Tamayo, Pablo
RA   Scott, Justine A.
RA   Rusin, Scott
RA   East-Seletsky, Alexandra
RA   Ali, Levi D.
RA   Gerath, William F.J.
RA   Pantel, Sarah E.
RA   Lizotte, Patrick Hall
RA   Jiang, Guo-Zhi
RA   Hsiao, Jessica
RA   Tsherniak, Aviad
RA   Dwinell, Elizabeth
RA   Aoyama, Simon
RA   Okamoto, Michael
RA   Harrington, William
RA   Gelfand, Ellen T.
RA   Green, Thomas M.
RA   Tomko, Mark J.
RA   Gopal, Shuba
RA   Wong, Terence C.
RA   Li, Hu-Bo
RA   Howell, Sara
RA   Stransky, Nicolas
RA   Liefeld, Ted
RA   Jang, Dongkeun
RA   Bistline, Jonathan
RA   Meyers, Barbara Hill
RA   Armstrong, Scott Allen
RA   Anderson, Kenneth Carl
RA   Stegmaier, Kimberly
RA   Reich, Michael
RA   Pellman, David
RA   Boehm, Jesse S.
RA   Mesirov, Jill P.
RA   Golub, Todd Robert
RA   Root, David E.
RA   Hahn, William Chun
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035.1-140035.12(2014).
//
RX   PubMed=11753612; DOI=10.1038/sj.leu.2402318;
RA   Xiao, Zhang-Xi
RA   Greaves, Melvyn Francis
RA   Buffler, Patricia Ann
RA   Smith, Martyn T.
RA   Segal, Mark R.
RA   Dicks, Brian M.
RA   Wiencke, John K.
RA   Wiemels, Joseph Leo
RT   "Molecular characterization of genomic AML1-ETO fusions in childhood
RT   leukemia.";
RL   Leukemia 15:1906-1913(2001).
//
RX   PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680;
RA   Skopek, Rafal
RA   Palusinska, Malgorzata
RA   Kaczor-Keller, Katarzyna
RA   Pingwara, Rafal
RA   Papierniak-Wygladala, Anna
RA   Schenk, Tino
RA   Lewicki, Slawomir
RA   Zelent, Artur
RA   Szymanski, Lukasz
RT   "Choosing the right cell line for acute myeloid leukemia (AML)
RT   research.";
RL   Int. J. Mol. Sci. 24:5377.1-5377.34(2023).
//
RX   PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886;
RA   Takizawa, Jun
RA   Suzuki, Ritsuro
RA   Kuroda, Hiroyuki
RA   Utsunomiya, Atae
RA   Kagami, Yoshitoyo
RA   Joh, Tatsuroh
RA   Aizawa, Yoshifusa
RA   Ueda, Ryuzo
RA   Seto, Masao
RT   "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not
RT   in adult T-cell leukemia.";
RL   Jpn. J. Cancer Res. 89:712-718(1998).
//