ID   SCLC-22H
AC   CVCL_2186
SY   SCLC22H
DR   CLO; CLO_0008973
DR   EFO; EFO_0006750
DR   ArrayExpress; E-MTAB-2706
DR   cancercelllines; CVCL_2186
DR   Cell_Model_Passport; SIDM00028
DR   CLS; 300445
DR   DepMap; ACH-001386
DR   DSMZ; ACC-373
DR   DSMZCellDive; ACC-373
DR   EGA; EGAS00001000610
DR   GEO; GSM784218
DR   PharmacoDB; SCLC22H_1362_2019
DR   Progenetix; CVCL_2186
DR   Wikidata; Q54952445
RX   PubMed=1320893;
RX   PubMed=1845952;
RX   PubMed=2438285;
RX   PubMed=2473086;
RX   PubMed=3029138;
RX   PubMed=11414198;
RX   PubMed=25485619;
RX   PubMed=25960936;
RX   PubMed=26589293;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: 75-85 hours (Note=Depending on growth medium) (PubMed=3029138); 75 hours (PubMed=2438285); ~48 hours (DSMZ=ACC-373).
CC   HLA typing: A*01:01,32:01; B*35:86,27:05; C*02:02,02:02 (PubMed=25960936).
CC   HLA typing: A*01:01,32:01; B*27:05,35:86; C*02:02,02:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro278Arg (c.833C>G); ClinVar=VCV000376644; Zygosity=Homozygous (DepMap=ACH-001386).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Pericardial effusion; UBERON=UBERON_0002409.
ST   Source(s): CLS=300445; DepMap=ACH-001386; DSMZ=ACC-373
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 12
ST   D16S539: 12
ST   D18S51: 14,15
ST   D19S433: 13,14
ST   D21S11: 29,31.2
ST   D2S1338: 17,20
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 11
ST   D8S1179: 12,13
ST   FGA: 22 (CLS=300445)
ST   FGA: 22,23 (DepMap=ACH-001386; DSMZ=ACC-373)
ST   Penta D: 9
ST   Penta E: 12,13
ST   TH01: 9.3
ST   TPOX: 8,9
ST   vWA: 17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_0024 ! SCLC-21H
SX   Male
AG   46Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 35
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y;
RA   Broers, Jos L.V.
RA   Mijnheere, Eddy P.
RA   Rot, Mirjam Klein
RA   Schaart, Gert
RA   Sijlmans, Alfred
RA   Boerman, Otto C.
RA   Ramaekers, Frans C.S.
RT   "Novel antigens characteristic of neuroendocrine malignancies.";
RL   Cancer 67:619-633(1991).
//
RX   PubMed=11414198; DOI=10.1007/s004320000207;
RA   Lahm, Harald
RA   Andre, Sabine
RA   Hoeflich, Andreas
RA   Fischer, Jurgen R.
RA   Sordat, Bernard
RA   Kaltner, Herbert
RA   Wolf, Eckhard
RA   Gabius, Hans-Joachim
RT   "Comprehensive galectin fingerprinting in a panel of 61 human tumor
RT   cell lines by RT-PCR and its implications for diagnostic and
RT   therapeutic procedures.";
RL   J. Cancer Res. Clin. Oncol. 127:375-386(2001).
//
RX   PubMed=1320893; DOI=10.1159/000163712;
RA   Verbeeck, Marken A.E.
RA   Elands, Jack P.M.
RA   de Leij, Lou F.M.H.
RA   Buys, Charles H.C.M.
RA   Carney, Desmond Niall
RA   Bepler, Gerold
RA   Roebroek, Anton J.M.
RA   van de Ven, Wim J.M.
RA   Burbach, J. Peter H.
RT   "Expression of the vasopressin and gastrin-releasing peptide genes in
RT   small cell lung carcinoma cell lines.";
RL   Pathobiology 60:136-142(1992).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=2473086; DOI=10.1242/jcs.91.1.91;
RA   Broers, Jos L.V.
RA   Rot, Mirjam Klein
RA   Oostendorp, Tineke
RA   Bepler, Gerold
RA   de Leij, Lou F.M.H.
RA   Carney, Desmond Niall
RA   Vooijs, Gijsbert Peter
RA   Ramaekers, Frans C.S.
RT   "Spontaneous changes in intermediate filament protein expression
RT   patterns in lung cancer cell lines.";
RL   J. Cell Sci. 91:91-108(1988).
//
RX   PubMed=3029138; DOI=10.1007/BF00389964;
RA   Bepler, Gerold
RA   Jaques, Gabriele
RA   Neumann, Kurt
RA   Aumuller, Gerhard
RA   Gropp, Claw
RA   Havemann, Klaus
RT   "Establishment, growth properties, and morphological characteristics
RT   of permanent human small cell lung cancer cell lines.";
RL   J. Cancer Res. Clin. Oncol. 113:31-40(1987).
//
RX   PubMed=2438285; DOI=10.1007/BF00396382;
RA   Bepler, Gerold
RA   Jaques, Gabriele
RA   Koehler, Angelika
RA   Gropp, Claw
RA   Havemann, Klaus
RT   "Markers and characteristics of human SCLC cell lines. Neuroendocrine
RT   markers, classical tumor markers, and chromosomal characteristics of
RT   permanent human small cell lung cancer cell lines.";
RL   J. Cancer Res. Clin. Oncol. 113:253-259(1987).
//