ID   L-5178-Y
AC   CVCL_2097
SY   L5178Y; LY
DR   BTO; BTO_0000795
DR   CLO; CLO_0007195
DR   CLO; CLO_0050168
DR   CLDB; cl3133
DR   ArrayExpress; E-TOXM-1
DR   ArrayExpress; E-TOXM-2
DR   ArrayExpress; E-TOXM-3
DR   ArrayExpress; E-TOXM-4
DR   ArrayExpress; E-TOXM-5
DR   ArrayExpress; E-TOXM-6
DR   ArrayExpress; E-TOXM-7
DR   ArrayExpress; E-TOXM-8
DR   ArrayExpress; E-TOXM-9
DR   ChEMBL-Cells; CHEMBL3307690
DR   ChEMBL-Targets; CHEMBL614720
DR   DSMZ; ACC-320
DR   DSMZCellDive; ACC-320
DR   ECACC; 87111908
DR   JCRB; JCRB0709
DR   Lonza; 1262
DR   PubChem_Cell_line; CVCL_2097
DR   RCB; RCB0135
DR   Wikidata; Q54900871
RX   PubMed=221956;
RX   PubMed=4321087;
RX   PubMed=6173370;
RX   PubMed=6413855;
RX   PubMed=6724617;
RX   PubMed=7565900;
RX   PubMed=15033590;
CC   Doubling time: 14.1 +- 1.6 hours (PubMed=221956); 11.3 hours (PubMed=6173370); ~20 hours (DSMZ=ACC-320); 10 hours (Note=Lot 07032005) (JCRB=JCRB0709).
CC   Transformant: ChEBI; CHEBI_34342; 3-methylcholanthrene (3-MC; 20-methylcholanthrene; 20-MC; MCA).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Thymus; UBERON=UBERON_0002370.
CC   Cell type: T-cell; CL=CL_0000084.
CC   Breed/subspecies: DBA/2.
DI   NCIt; C134997; Mouse thymic lymphoma
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
SX   Female
AG   8M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 20
CH   CVCL_4234 ! L-5178-Y-R
CH   CVCL_C8YC ! L5178Y Adh
CH   CVCL_UZ88 ! L5178Y BLM-A2-R
CH   CVCL_L282 ! L5178Y LX821
CH   CVCL_L283 ! L5178Y LX827
CH   CVCL_7882 ! L5178Y LX830
CH   CVCL_L284 ! L5178Y M10
CH   CVCL_J373 ! L5178Y ts2
CH   CVCL_J374 ! L5178Y ts39
CH   CVCL_AZ79 ! L5178Y VCRR
CH   CVCL_AZ80 ! L5178Y VDSR
CH   CVCL_C8YD ! L5178Y(A)
CH   CVCL_E4AB ! L5178Y/hFASL
CH   CVCL_C8YG ! L5718YF
CH   CVCL_F0B5 ! LR.4
//
RX   PubMed=6413855; DOI=10.1016/0165-7992(83)90215-4;
RA   Sato, Koki
RA   Hieda-Shiomi, Naoko
RA   Hama-Inaba, Hiroko
RT   "X-ray-sensitive mutant mouse cells with various sensitivities to
RT   chemical mutagens.";
RL   Mutat. Res. 121:281-285(1983).
//
RX   PubMed=4321087;
RA   Kessel, David H.
RA   Bosmann, H. Bruce
RT   "On the characteristics of actinomycin D resistance in L5178Y cells.";
RL   Cancer Res. 30:2695-2701(1970).
//
RX   PubMed=221956; DOI=10.2307/3575014;
RA   Sato, Koki
RA   Hieda, Naoko
RT   "Isolation and characterization of a mutant mouse lymphoma cell
RT   sensitive to methyl methanesulfonate and X rays.";
RL   Radiat. Res. 78:167-171(1979).
//
RX   PubMed=6173370; DOI=10.7164/antibiotics.34.1210;
RA   Suzuki, Hideo
RA   Nishimura, Toshio
RA   Tanaka, Nobuo
RT   "Drug sensitivity and some characteristics of a bleomycin-resistant
RT   subline of mouse lymphoblastoma L5178Y cells.";
RL   J. Antibiot. 34:1210-1212(1981).
//
RX   PubMed=6724617; DOI=10.1007/BF02619582;
RA   Ankel, Else G.
RA   Zirneski, Joseph
RA   Ring, Barbara J.
RA   Holcenberg, John Stanley
RT   "Effect of asparaginase on cell membranes of sensitive and resistant
RT   mouse lymphoma cells.";
RL   In Vitro 20:376-384(1984).
//
RX   PubMed=7565900; DOI=10.1016/0165-7992(95)00027-5;
RA   Zhang, Li-Shi
RA   Honma, Masamitsu
RA   Hayashi, Makoto
RA   Suzuki, Takayoshi
RA   Matsuoka, Atsuko
RA   Sofuni, Toshio
RT   "A comparative study of TK6 human lymphoblastoid and L5178Y mouse
RT   lymphoma cell lines in the in vitro micronucleus test.";
RL   Mutat. Res. 347:105-115(1995).
//
RX   PubMed=15033590; DOI=10.1289/ehp.6709; PMCID=PMC1241894;
RA   Newton, Ronald K.
RA   Aardema, Marilyn J.
RA   Aubrecht, Jiri
RT   "The utility of DNA microarrays for characterizing genotoxicity.";
RL   Environ. Health Perspect. 112:420-422(2004).
//