ID   KCI-MOH1
AC   CVCL_2090
SY   KciMoh-1; KCIMOH1; WSU-MOH1
DR   EFO; EFO_0006608
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03151779
DR   cancercelllines; CVCL_2090
DR   Cell_Model_Passport; SIDM01933
DR   DepMap; ACH-001098
DR   DSMZ; ACC-498
DR   DSMZCellDive; ACC-498
DR   EGA; EGAS00001000610
DR   GEO; GSM887201
DR   GEO; GSM888274
DR   PharmacoDB; KCIMOH1_738_2019
DR   Progenetix; CVCL_2090
DR   Wikidata; Q54899646
RX   DOI=10.22029/jlupub-12385;
RX   PubMed=9436858;
RX   PubMed=15770730;
RX   PubMed=20143388;
RX   PubMed=22460905;
RX   PubMed=25485619;
RX   PubMed=26216984;
RX   PubMed=26589293;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HPAC derivative (PubMed=20143388). Originally thought to originate from a 74 year old male patient with a moderately differentiated adenocarcinoma of the head of the pancreas.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00322.
CC   Population: Caucasian.
CC   Doubling time: ~70 hours (DSMZ=ACC-498).
CC   HLA typing: A*03:01,03:01; B*14:02,14:02; C*08:02,08:02 (PubMed=26589293).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu120Ter (c.358G>T); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Unspecified (from parent cell line).
CC   Omics: Metabolomics.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=0.11%; East Asian, North=2.33%; East Asian, South=0%; South Asian=0%; European, North=65.07%; European, South=32.5% (PubMed=30894373).
CC   Discontinued: BioIVT/Asterand Bioscience; Catalog number WSU-MOH1.
CC   Discontinued: DSMZ; ACC-498; true.
CC   Derived from site: In situ; Pancreas; UBERON=UBERON_0001264.
CC   Cell type: Pancreatic ductal cell; CL=CL_0002079.
ST   Source(s): DSMZ=ACC-498
ST   Amelogenin: X
ST   CSF1PO: 13
ST   D13S317: 11
ST   D16S539: 9,10
ST   D18S51: 16
ST   D19S433: 14
ST   D21S11: 30
ST   D2S1338: 19,23
ST   D3S1358: 15,17
ST   D5S818: 12
ST   D7S820: 10,12
ST   D8S1179: 12,14
ST   FGA: 24
ST   Penta D: 13
ST   Penta E: 15
ST   TH01: 9.3
ST   TPOX: 10,11
ST   vWA: 15,17
DI   NCIt; C8294; Pancreatic adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3517 ! HPAC
SX   Female
AG   64Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 37
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   DOI=10.22029/jlupub-12385;
RA   Oberlin, Laura
RT   "Treatment of pancreatic carcinoma cell lines in vitro and vivo with a
RT   monoclonal antibody against the transferrin receptor.";
RL   Thesis VMD (2009); Justus-Liebig-Universitat Giessen; Giessen; Germany.
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=9436858; DOI=10.1097/00006676-199801000-00004;
RA   Mohammad, Ramzi M.
RA   Dugan, Michael C.
RA   Mohamed, Anwar N.
RA   Almatchy, Victor Petros
RA   Flake, Thomas M.
RA   Dergham, Sanaa T.
RA   Shields, Anthony F.
RA   Al-Katib, Ayad M.
RA   Vaitkevicius, Vainutis Kazimieras
RA   Sarkar, Fazlul H.
RT   "Establishment of a human pancreatic tumor xenograft model: potential
RT   application for preclinical evaluation of novel therapeutic agents.";
RL   Pancreas 16:19-25(1998).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=15770730; DOI=10.3748/wjg.v11.i10.1521; PMCID=PMC4305696;
RA   Ma, Jian-Hua
RA   Patrut, Emilia
RA   Schmidt, Jan
RA   Knaebel, Hanns-Peter
RA   Buchler, Markus Wolfgang
RA   Marten, Alexandra
RT   "Synergistic effects of interferon-alpha in combination with
RT   chemoradiation on human pancreatic adenocarcinoma.";
RL   World J. Gastroenterol. 11:1521-1528(2005).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=26216984; DOI=10.1073/pnas.1501605112; PMCID=PMC4538616;
RA   Daemen, Anneleen
RA   Peterson, David
RA   Sahu, Nisebita
RA   McCord, Ron
RA   Du, Xiang-Nan
RA   Liu, Bonnie
RA   Kowanetz, Katarzyna
RA   Hong, Rebecca
RA   Moffat, John
RA   Gao, Min
RA   Boudreau, Aaron
RA   Mroue, Rana
RA   Corson, Laura
RA   O'Brien, Thomas
RA   Qing, Jing
RA   Sampath, Deepak
RA   Merchant, Mark
RA   Yauch, Robert L.
RA   Manning, Gerard
RA   Settleman, Jeffrey
RA   Hatzivassiliou, Georgia
RA   Evangelista, Marie
RT   "Metabolite profiling stratifies pancreatic ductal adenocarcinomas
RT   into subtypes with distinct sensitivities to metabolic inhibitors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015).
//