ID   JOSK-M
AC   CVCL_2083
DR   CLO; CLO_0007035
DR   CLDB; cl2952
DR   BioSample; SAMN03151982
DR   BioSample; SAMN03473345
DR   cancercelllines; CVCL_2083
DR   Cosmic; 787439
DR   Cosmic; 999773
DR   DSMZ; ACC-30
DR   DSMZCellDive; ACC-30
DR   IARC_TP53; 961
DR   Wikidata; Q54899047
RX   PubMed=3486043;
RX   PubMed=10508494;
RX   PubMed=12592342;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a U-937 derivative (PubMed=10508494; PubMed=12592342; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00137.
CC   Population: Caucasian.
CC   Doubling time: ~30-40 hours (DSMZ=ACC-30).
CC   Sequence variation: Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Discontinued: DSMZ; ACC-30; true.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): DSMZ=ACC-30
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 10,12
ST   D16S539: 12
ST   D18S51: 13,14
ST   D19S433: 14,16
ST   D21S11: 27,29
ST   D2S1338: 17,20
ST   D3S1358: 16
ST   D5S818: 13
ST   D7S820: 9,11
ST   D8S1179: 11,16
ST   FGA: 22,25
ST   Penta D: 12,13
ST   Penta E: 11,13
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 14,15
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0007 ! U-937
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 30
//
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler, Hans Gunther
RA   Dirks, Wilhelm Gerhard
RA   Matsuo, Yoshinobu
RA   MacLeod, Roderick A.F.
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
//
RX   PubMed=3486043;
RA   Ohta, Masatsugu
RA   Furukawa, Yusuke
RA   Ide, Chizuka
RA   Akiyama, Nobuo
RA   Utakoji, Tadashi
RA   Miura, Yasusada
RA   Saito, Masaki
RT   "Establishment and characterization of four human monocytoid leukemia
RT   cell lines (JOSK-I, -S, -M and -K) with capabilities of
RT   monocyte-macrophage lineage differentiation and constitutive production
RT   of interleukin 1.";
RL   Cancer Res. 46:3067-3074(1986).
//
RX   PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2;
RA   MacLeod, Roderick A.F.
RA   Dirks, Wilhelm Gerhard
RA   Matsuo, Yoshinobu
RA   Kaufmann, Maren
RA   Milch, Herbert
RA   Drexler, Hans Gunther
RT   "Widespread intraspecies cross-contamination of human tumor cell lines
RT   arising at source.";
RL   Int. J. Cancer 83:555-563(1999).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//