ID   JOSK-M
AC   CVCL_2083
DR   CLO; CLO_0007035
DR   CLDB; cl2952
DR   BioSample; SAMN03151982
DR   BioSample; SAMN03473345
DR   cancercelllines; CVCL_2083
DR   Cosmic; 787439
DR   Cosmic; 999773
DR   DSMZ; ACC-30
DR   DSMZCellDive; ACC-30
DR   IARC_TP53; 961
DR   Wikidata; Q54899047
RX   PubMed=3486043;
RX   PubMed=10508494;
RX   PubMed=12592342;
RX   PubMed=20143388;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a U-937 derivative (PubMed=10508494; PubMed=12592342; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00137.
CC   Population: Caucasian.
CC   Doubling time: ~30-40 hours (DSMZ=ACC-30).
CC   Sequence variation: Gene fusion; HGNC; 16063; MLLT10 + HGNC; 15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Discontinued: DSMZ; ACC-30; true.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): DSMZ=ACC-30
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 10,12
ST   D16S539: 12
ST   D18S51: 13,14
ST   D19S433: 14,16
ST   D21S11: 27,29
ST   D2S1338: 17,20
ST   D3S1358: 16
ST   D5S818: 13
ST   D7S820: 9,11
ST   D8S1179: 11,16
ST   FGA: 22,25
ST   Penta D: 12,13
ST   Penta E: 11,13
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 14,15
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0007 ! U-937
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 28
//
RX   PubMed=3486043;
RA   Ohta M., Furukawa Y., Ide C., Akiyama N., Utakoji T., Miura Y.,
RA   Saito M.;
RT   "Establishment and characterization of four human monocytoid leukemia
RT   cell lines (JOSK-I, -S, -M and -K) with capabilities of
RT   monocyte-macrophage lineage differentiation and constitutive production
RT   of interleukin 1.";
RL   Cancer Res. 46:3067-3074(1986).
//
RX   PubMed=10508494; DOI=10.1002/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2;
RA   MacLeod R.A.F., Dirks W.G., Matsuo Y., Kaufmann M., Milch H.,
RA   Drexler H.G.;
RT   "Widespread intraspecies cross-contamination of human tumor cell lines
RT   arising at source.";
RL   Int. J. Cancer 83:555-563(1999).
//
RX   PubMed=12592342; DOI=10.1038/sj.leu.2402799;
RA   Drexler H.G., Dirks W.G., Matsuo Y., MacLeod R.A.F.;
RT   "False leukemia-lymphoma cell lines: an update on over 500 cell
RT   lines.";
RL   Leukemia 17:416-426(2003).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//