ID HCC33 AC CVCL_2058 SY HCC-33; HCC0033; Hamon Cancer Center 33 DR BTO; BTO_0006529 DR CLO; CLO_0010000 DR EFO; EFO_0006417 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR BioSample; SAMN03473100 DR BioSample; SAMN10987702 DR cancercelllines; CVCL_2058 DR Cell_Model_Passport; SIDM01071 DR Cosmic; 877235 DR Cosmic; 1219093 DR Cosmic; 1239927 DR Cosmic; 1320184 DR Cosmic; 1518101 DR Cosmic; 2125212 DR Cosmic-CLP; 1303901 DR DepMap; ACH-000515 DR DSMZ; ACC-487 DR DSMZCellDive; ACC-487 DR EGA; EGAS00001000610 DR GDSC; 1303901 DR GEO; GSM171904 DR GEO; GSM171905 DR GEO; GSM794373 DR GEO; GSM887052 DR GEO; GSM888122 DR GEO; GSM1669857 DR IARC_TP53; 28312 DR KCLB; 70033 DR LiGeA; CCLE_798 DR LINCS_LDP; LCL-1833 DR PharmacoDB; HCC33_457_2019 DR PRIDE; PXD030304 DR Progenetix; CVCL_2058 DR Wikidata; Q54881692 RX PubMed=9559342; RX PubMed=10987304; RX PubMed=11314036; RX PubMed=19472407; RX PubMed=20557307; RX PubMed=20679594; RX PubMed=22460905; RX PubMed=22961666; RX PubMed=23716474; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31803961; RX PubMed=35839778; WW Provider; UT Southwestern; -; https://www.utsouthwestern.edu/edumedia/edufiles/about_us/admin_offices/technology_development/available_technologies/cell-lines.pdf CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Caucasian. CC Doubling time: ~40 hours (DSMZ=ACC-487). CC HLA typing: A*03:01,24:02; B*07:02,07:02; C*07:02,07:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Gene fusion; HGNC; HGNC:32308; C1QTNF12 + HGNC; HGNC:10025; RLF; Name(s)=RLF-C1QTNF12, RLF-FAM132A (PubMed=23716474). CC Sequence variation: Gene fusion; HGNC; HGNC:10025; RLF + HGNC; HGNC:19268; UBE2J2; Name(s)=RLF-UBE2J2 (PubMed=23716474). CC Sequence variation: Mutation; HGNC; HGNC:9884; RB1; Simple; p.Ser402fs*8 (c.1202delT) (p.I401fs); Zygosity=Heterozygous (Cosmic-CLP=1303901; DepMap=ACH-000515). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys242Tyr (c.725G>A); ClinVar=VCV000012354; Zygosity=Homozygous (PubMed=20557307; Cosmic-CLP=1303901; DepMap=ACH-000515). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=2.5%; Native American=0%; East Asian, North=2.1%; East Asian, South=0%; South Asian=0.21%; European, North=61.5%; European, South=33.69% (PubMed=30894373). CC Miscellaneous: Direct author submission of STR profile from Girard, Luc and Gazdar, Adi F. CC Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. ST Source(s): Cosmic-CLP=1303901; Direct_author_submission; DSMZ=ACC-487; PubMed=20679594; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 11 ST D13S317: 11,13 ST D16S539: 11,12 ST D18S51: 12,17 ST D19S433: 14,15 ST D21S11: 30,32 ST D2S1338: 16,25 ST D3S1358: 16 ST D5S818: 11 ST D7S820: 11 ST D8S1179: 13,14 ST FGA: 20,23 ST Penta D: 10,12 ST Penta E: 14 ST TH01: 9 ST TPOX: 8,11 ST vWA: 16,18 DI NCIt; C4917; Lung small cell carcinoma DI ORDO; Orphanet_70573; Small cell lung cancer OX NCBI_TaxID=9606; ! Homo sapiens (Human) OI CVCL_L063 ! HCC33 BL SX Male AG 52Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 44 // RX PubMed=9559342; DOI=10.1002/(SICI)1098-2264(199804)21:4<308::AID-GCC4>3.0.CO;2-2; RA Virmani A.K., Fong K.M., Kodagoda D.R., McIntire D., Hung J.Y., Tonk V., RA Minna J.D., Gazdar A.F.; RT "Allelotyping demonstrates common and distinct patterns of chromosomal RT loss in human lung cancer types."; RL Genes Chromosomes Cancer 21:308-319(1998). // RX PubMed=10987304; RA Girard L., Zochbauer-Muller S., Virmani A.K., Gazdar A.F., Minna J.D.; RT "Genome-wide allelotyping of lung cancer identifies new regions of RT allelic loss, differences between small cell lung cancer and non-small RT cell lung cancer, and loci clustering."; RL Cancer Res. 60:4894-4906(2000). // RX PubMed=11314036; DOI=10.1038/sj.onc.1204211; RA Forgacs E., Wren J.D., Kamibayashi C., Kondo M., Xu X.L., RA Markowitz S.D., Tomlinson G.E., Muller C.Y., Gazdar A.F., Garner H.R., RA Minna J.D.; RT "Searching for microsatellite mutations in coding regions in lung, RT breast, ovarian and colorectal cancers."; RL Oncogene 20:1005-1009(2001). // RX PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846; RA Blanco R., Iwakawa R., Tang M.-Y., Kohno T., Angulo B., Pio R., RA Montuenga L.M., Minna J.D., Yokota J., Sanchez-Cespedes M.; RT "A gene-alteration profile of human lung cancer cell lines."; RL Hum. Mutat. 30:1199-1206(2009). // RX PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680; RA Iwakawa R., Kohno T., Enari M., Kiyono T., Yokota J.; RT "Prevalence of human papillomavirus 16/18/33 infection and p53 RT mutation in lung adenocarcinoma."; RL Cancer Sci. 101:1891-1896(2010). // RX PubMed=20679594; DOI=10.1093/jnci/djq279; PMCID=PMC2935474; RA Gazdar A.F., Girard L., Lockwood W.W., Lam W.L., Minna J.D.; RT "Lung cancer cell lines as tools for biomedical discovery and RT research."; RL J. Natl. Cancer Inst. 102:1310-1321(2010). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., RA Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., RA Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., RA Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., RA Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., RA Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., RA Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., RA Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., RA Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., RA Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., RA Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.; RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922; RA Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., RA Yordy J.S., Giri U., Peyton M., Fan Y.-H., Diao L.-X., Masrorpour F., RA Shen L., Liu W.-B., Duchemann B., Tumula P., Bhardwaj V., Welsh J., RA Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., RA Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., RA Heymach J.V.; RT "Proteomic profiling identifies dysregulated pathways in small cell RT lung cancer and novel therapeutic targets including PARP1."; RL Cancer Discov. 2:798-811(2012). // RX PubMed=23716474; DOI=10.1002/gcc.22076; PMCID=PMC3806277; RA Iwakawa R., Takenaka M., Kohno T., Shimada Y., Totoki Y., Shibata T., RA Tsuta K., Nishikawa R., Noguchi M., Sato-Otsubo A., Ogawa S., RA Yokota J.; RT "Genome-wide identification of genes with amplification and/or fusion RT in small cell lung cancer."; RL Genes Chromosomes Cancer 52:802-816(2013). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., RA Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., RA Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., RA Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., RA Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., RA Settleman J., Seshagiri S., Zhang Z.-M.; RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., RA Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., RA Neve R.M.; RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., RA Loewer M., Sahin U., Castle J.C.; RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., RA Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., RA Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., RA Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., RA Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., RA Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., RA Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., RA Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.; RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.; RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., RA McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., RA Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., RA Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., RA Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., RA Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., RA Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., RA Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., RA Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., RA Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., RA Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., RA Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., RA Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., RA Sellers W.R.; RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084; RA Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A., RA Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M., RA Aldige C.R., Wistuba I.I., Minna J.D.; RT "From clinical specimens to human cancer preclinical models -- a journey RT the NCI-cell line database-25 years later."; RL J. Cell. Biochem. 121:3986-3999(2020). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., RA Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., RA Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., RA Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., RA Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., RA Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.; RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). //