ID   FM3
AC   CVCL_2046
SY   FM-3
DR   cancercelllines; CVCL_2046
DR   Cosmic; 808544
DR   Cosmic; 851400
DR   Cosmic; 1047663
DR   ECACC; 13012407
DR   ESTDAB; ESTDAB-007
DR   GEO; GSM156042
DR   IARC_TP53; 26090
DR   Progenetix; CVCL_2046
DR   Wikidata; Q54835025
RX   PubMed=7656272;
RX   PubMed=7899823;
RX   PubMed=8665567;
RX   PubMed=8968104;
RX   PubMed=9288767;
RX   PubMed=15592718;
RX   PubMed=17260012;
RX   PubMed=23851445;
CC   HLA typing: A*02,03; B*07,44 (PubMed=7656272).
CC   HLA typing: A*02:01; B*07:02,44:02; C*05:01; DPB1*04:01; DQB1*06:02,03:01:01; DRB1*04:01:01,15:01 (PubMed=15592718).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=17260012; PubMed=23851445).
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: Metastatic; Right inguinal lymph node; UBERON=UBERON_0001542.
ST   Source(s): ECACC=13012407; ESTDAB=ESTDAB-007
ST   Amelogenin: X
ST   CSF1PO: 11,13
ST   D13S317: 12
ST   D16S539: 12,13
ST   D3S1358: 15,17
ST   D5S818: 12
ST   D7S820: 10
ST   FGA: 23
ST   TH01: 6,9.3
ST   TPOX: 8,11
ST   vWA: 15,16
DI   NCIt; C3510; Cutaneous melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 24
CH   CVCL_C578 ! FM3.13
CH   CVCL_C579 ! FM3.26
CH   CVCL_C580 ! FM3.29
CH   CVCL_UI31 ! FM3.D
CH   CVCL_UI32 ! FM3.P
//
RX   PubMed=9288767;
RA   Guldberg, Per
RA   thor Straten, Per
RA   Birck, Anette
RA   Ahrenkiel, Vibeke
RA   Kirkin, Alexei F.
RA   Zeuthen, Jesper
RT   "Disruption of the MMAC1/PTEN gene by deletion or mutation is a
RT   frequent event in malignant melanoma.";
RL   Cancer Res. 57:3660-3663(1997).
//
RX   PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006;
RA   Dahl, Christina
RA   Christensen, Claus
RA   Jonsson, Goran
RA   Lorentzen, Anders
RA   Skjodt, Mette Louise
RA   Borg, Ake
RA   Pawelec, Graham
RA   Guldberg, Per
RT   "Mutual exclusivity analysis of genetic and epigenetic drivers in
RT   melanoma identifies a link between p14 ARF and RARbeta signaling.";
RL   Mol. Cancer Res. 11:1166-1178(2013).
//
RX   PubMed=7656272; DOI=10.1007/BF01527402; PMCID=PMC11037630;
RA   Kirkin, Alexei F.
RA   Petersen, Troels Reichert
RA   Olsen, Anna Catharina
RA   Li, Li
RA   thor Straten, Per
RA   Zeuthen, Jesper
RT   "Generation of human-melanoma-specific T lymphocyte clones defining
RT   novel cytolytic targets with panels of newly established melanoma cell
RT   lines.";
RL   Cancer Immunol. Immunother. 41:71-81(1995).
//
RX   PubMed=15592718; DOI=10.1007/s00262-004-0561-5; PMCID=PMC11032966;
RA   Rodriguez, Teresa
RA   Mendez, Rosa
RA   Roberts, Chrissy H.
RA   Ruiz-Cabello Osuna, Francisco
RA   Dodi, I. Anthony
RA   Lopez-Nevot, Miguel Angel
RA   Paco, Laura
RA   Maleno, Isabel
RA   Marsh, Steven G.E.
RA   Pawelec, Graham
RA   Garrido, Federico
RT   "High frequency of homozygosity of the HLA region in melanoma cell
RT   lines reveals a pattern compatible with extensive loss of
RT   heterozygosity.";
RL   Cancer Immunol. Immunother. 54:141-148(2005).
//
RX   PubMed=17260012; DOI=10.1038/sj.onc.1210252;
RA   Jonsson, Goran
RA   Dahl, Christina
RA   Staaf, Johan
RA   Sandberg, Troy
RA   Bendahl, Par-Ola
RA   Ringner, Markus
RA   Guldberg, Per
RA   Borg, Ake
RT   "Genomic profiling of malignant melanoma using tiling-resolution
RT   arrayCGH.";
RL   Oncogene 26:4738-4748(2007).
//
RX   PubMed=8665567; DOI=10.1007/s002620050272; PMCID=PMC11037612;
RA   Kirkin, Alexei F.
RA   thor Straten, Per
RA   Zeuthen, Jesper
RT   "Differential modulation by interferon gamma of the sensitivity of
RT   human melanoma cells to cytolytic T cell clones that recognize
RT   differentiation or progression antigens.";
RL   Cancer Immunol. Immunother. 42:203-212(1996).
//
RX   PubMed=8968104;
RA   Bartkova, Jirina
RA   Lukas, Jiri
RA   Guldberg, Per
RA   Alsner, Jan
RA   Kirkin, Alexei F.
RA   Zeuthen, Jesper
RA   Bartek, Jiri
RT   "The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently
RT   altered in melanoma pathogenesis.";
RL   Cancer Res. 56:5475-5483(1996).
//
RX   PubMed=7899823; DOI=10.1111/j.1365-3083.1995.tb03579.x;
RA   Olsen, Anna Catharina
RA   Fossum, Beate
RA   Kirkin, Alexei F.
RA   Zeuthen, Jesper
RA   Gaudernack, Gustav
RT   "A human melanoma cell line, recognized by both HLA class I and class
RT   II restricted T cells, is capable of initiating both primary and
RT   secondary immune responses.";
RL   Scand. J. Immunol. 41:357-364(1995).
//