ID   EB1
AC   CVCL_2027
AS   CVCL_2026
SY   EB-1; Epstein-Barr-1
DR   BTO; BTO_0003000
DR   CLO; CLO_0002869
DR   CLO; CLO_0002870
DR   EFO; EFO_0002172
DR   CLDB; cl1127
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ATCC; HTB-60
DR   BioSample; SAMN03472402
DR   BioSample; SAMN03473402
DR   BioSample; SAMN10987945
DR   cancercelllines; CVCL_2027
DR   Cell_Model_Passport; SIDM00862
DR   CLS; 300403
DR   Cosmic; 1086328
DR   Cosmic; 1818341
DR   DepMap; ACH-000877
DR   DSMZ; ACC-80
DR   DSMZCellDive; ACC-80
DR   EGA; EGAS00001000610
DR   GEO; GSM827341
DR   GEO; GSM886991
DR   GEO; GSM888060
DR   IARC_TP53; 21315
DR   IGRhCellID; EB1
DR   LiGeA; CCLE_384
DR   LINCS_LDP; LCL-2030
DR   PharmacoDB; EB1_313_2019
DR   Progenetix; CVCL_2027
DR   Wikidata; Q54831741
RX   PubMed=2998993;
RX   PubMed=3518877;
RX   PubMed=4894370;
RX   PubMed=5884338;
RX   PubMed=6018567;
RX   PubMed=7316467;
RX   PubMed=8515068;
RX   PubMed=8558920;
RX   PubMed=12145705;
RX   PubMed=14090852;
RX   PubMed=14293790;
RX   PubMed=14293791;
RX   PubMed=20215515;
RX   PubMed=20454443;
RX   PubMed=22460905;
RX   PubMed=24590883;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=28196595;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: African; Ugandan.
CC   Doubling time: ~2 days (CLS=300403); ~30-40 hours (DSMZ=ACC-80).
CC   HLA typing: A*29:02,31:04; B*47:03,57:03; C*07:01,07:01; DQA1*01:02,05:01; DQB1*03:01,06:09; DRB1*11:02,13:02' (PubMed=26589293).
CC   HLA typing: A*29:02:01,31:04:01; B*47:03:01,57:03:01; C*07:01:02,07:18:01; DPB1*13:01:01G,30:01:01; DQA1*01:02:01,05:05:01; DQB1*03:01,06:04:01; DRB1*11:02:01,13:02:01 (CLS=300403).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly244Asp (c.731G>A); ClinVar=VCV000372785; Zygosity=Unspecified (DepMap=ACH-000877).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=94.08%; Native American=0%; East Asian, North=1.53%; East Asian, South=0%; South Asian=1.12%; European, North=0%; European, South=3.27% (PubMed=30894373).
CC   Derived from site: In situ; Bone, jaw, maxilla; UBERON=UBERON_0002397.
CC   Cell type: B-cell; CL=CL_0000236.
ST   Source(s): ATCC=HTB-60; CLS=300403; DSMZ=ACC-80; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11,13
ST   D16S539: 8,10
ST   D18S51: 15,16
ST   D19S433: 14,14.2 (ATCC=HTB-60)
ST   D19S433: 14,15 (DSMZ=ACC-80)
ST   D21S11: 30,32.2
ST   D2S1338: 21,24
ST   D3S1358: 16,17
ST   D5S818: 8,12
ST   D7S820: 10,12
ST   D8S1179: 14,15
ST   FGA: 24,30
ST   Penta D: 6.3,13 (PubMed=25877200)
ST   Penta D: 6.4,13 (ATCC=HTB-60; CLS=300403)
ST   Penta D: 7,13 (DSMZ=ACC-80)
ST   Penta E: 13,17
ST   TH01: 9,9.3 (ATCC=HTB-60; CLS=300403; PubMed=25877200)
ST   TH01: 9,10 (DSMZ=ACC-80)
ST   TPOX: 8,9
ST   vWA: 14,16
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   9Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 40
//
RX   PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168;
RA   Uphoff, Cord C.
RA   Denkmann, Sabine A.
RA   Steube, Klaus G.
RA   Drexler, Hans Gunther
RT   "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human
RT   and other primate cell lines.";
RL   J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=24590883; DOI=10.1002/gcc.22161;
RA   Murga Penas, Eva-Maria
RA   Schilling, Georgia
RA   Behrmann, Petra
RA   Klokow, Marianne
RA   Vettorazzi, Eik
RA   Bokemeyer, Carsten
RA   Dierlamm, Judith
RT   "Comprehensive cytogenetic and molecular cytogenetic analysis of 44
RT   Burkitt lymphoma cell lines: secondary chromosomal changes
RT   characterization, karyotypic evolution, and comparison with primary
RT   samples.";
RL   Genes Chromosomes Cancer 53:497-515(2014).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=4894370; DOI=10.1002/1097-0142(196908)24:2<211::AID-CNCR2820240202>3.0.CO;2-3;
RA   Southam, Chester Milton
RA   Burchenal, Joseph Holland
RA   Clarkson, Bayard Delafield Sr.
RA   Tanzi, Adrienne
RA   Mackey, Rosemary
RA   McComb, Vivian
RT   "Heterotransplantability of human cell lines derived from leukemia and
RT   lymphomas into immunologically tolerant rats.";
RL   Cancer 24:211-222(1969).
//
RX   PubMed=5884338;
RA   Epstein, Michael Anthony
RA   Barr, Yvonne Margaret
RA   Achong, Bert Geoffrey
RT   "Studies with Burkitt's lymphoma.";
RL   Wistar Inst. Symp. Monogr. 4:69-82(1965).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=8558920;
RA   Dirks, Wilhelm Gerhard
RA   Zaborski, Margarete
RA   Jager, Kathrin
RA   Challier, Cecile
RA   Shiota, Mami
RA   Quentmeier, Hilmar
RA   Drexler, Hans Gunther
RT   "The (2;5)(p23;q35) translocation in cell lines derived from malignant
RT   lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.";
RL   Leukemia 10:142-149(1996).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=12145705; DOI=10.1038/sj.leu.2402519;
RA   Langerak, Anton W.
RA   Moreau, Elisabeth J.
RA   van Gastel-Mol, Ellen J.
RA   van der Burg, Mirjam
RA   van Dongen, Jacobus Johannes Maria
RT   "Detection of clonal EBV episomes in lymphoproliferations as a
RT   diagnostic tool.";
RL   Leukemia 16:1572-1573(2002).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786;
RA   Tan, Kar-Tong
RA   Ding, Ling-Wen
RA   Sun, Qiao-Yang
RA   Lao, Zhen-Tang
RA   Chien, Wenwen
RA   Ren, Xi
RA   Xiao, Jin-Fen
RA   Loh, Xin-Yi
RA   Xu, Liang
RA   Lill, Michael
RA   Mayakonda, Anand
RA   Lin, De-Chen
RA   Yang, Henry He
RA   Koeffler, Harold Phillip
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh, Jorgen
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=6018567;
RA   Miles, Charles P.
RA   O'Neill, Frank
RT   "Chromosome studies of 8 in vitro lines of Burkitt's lymphoma.";
RL   Cancer Res. 27:392-402(1967).
//
RX   PubMed=14293791; DOI=10.1093/jnci/34.2.241;
RA   Epstein, Michael Anthony
RA   Achong, Bert Geoffrey
RT   "Fine structural organization of human lymphoblasts of a tissue
RT   culture strain (EB1) from Burkitt's lymphoma.";
RL   J. Natl. Cancer Inst. 34:241-253(1965).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=8515068; DOI=10.4049/jimmunol.150.12.5418;
RA   Jain, Vinay K.
RA   Judde, Jean-Gabriel
RA   Max, Edward E.
RA   Magrath, Ian Trevor
RT   "Variable IgH chain enhancer activity in Burkitt's lymphomas suggests
RT   an additional, direct mechanism of c-myc deregulation.";
RL   J. Immunol. 150:5418-5428(1993).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144;
RA   Uphoff, Cord C.
RA   Pommerenke, Claudia
RA   Denkmann, Sabine A.
RA   Drexler, Hans Gunther
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:e0210404.1-e0210404.22(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=14293790; DOI=10.1093/jnci/34.2.231;
RA   Epstein, Michael Anthony
RA   Barr, Yvonne Margaret
RT   "Characteristics and mode of growth of tissue culture strain (EB1) of
RT   human lymphoblasts from Burkitt's lymphoma.";
RL   J. Natl. Cancer Inst. 34:231-240(1965).
//
RX   PubMed=14090852; DOI=10.1016/S0140-6736(64)92354-2;
RA   Epstein, Michael Anthony
RA   Barr, Yvonne Margaret
RT   "Cultivation in vitro of human lymphoblasts from Burkitt's malignant
RT   lymphoma.";
RL   Lancet 283:252-253(1964).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=2998993;
RA   Steel, Christopher Michael
RA   Morten, John E.N.
RA   Foster, Michael E.
RT   "The cytogenetics of human B lymphoid malignancy: studies in Burkitt's
RT   lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell
RT   lines.";
RL   IARC Sci. Publ. 60:265-292(1985).
//
RX   PubMed=7316467; DOI=10.1111/j.1469-1809.1980.tb00953.x;
RA   Povey, Susan
RA   Jeremiah, Stephen
RA   Arthur, Elizabeth
RA   Steel, C. Michael
RA   Klein, George
RT   "Differences in genetic stability between human cell lines from
RT   patients with and without lymphoreticular malignancy.";
RL   Ann. Hum. Genet. 44:119-133(1980).
//