ID   DT40-RASGRP1(-/-)-RASGRP3(-/-)
AC   CVCL_1U39
SY   GRP1^(-)/GRP3^(-)DT40
DR   CLO; CLO_0051511
DR   RCB; RCB1865
DR   Wikidata; Q54831531
RX   PubMed=14676298;
CC   Group: Bird cell line.
CC   Knockout cell: Method=Targeted integration; CGNC; 7404; RASGRP1.
CC   Knockout cell: Method=Targeted integration; CGNC; 7943; RASGRP3.
CC   Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
CC   Cell type: B-cell; CL=CL_0000236.
CC   Breed/subspecies: Hy-Line SC.
DI   NCIt; C134556; Chicken bursal lymphoma
OX   NCBI_TaxID=9031; ! Gallus gallus (Chicken)
HI   CVCL_0249 ! DT40
SX   Female
AG   1D
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-09-24; Version: 11
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RX   PubMed=14676298; DOI=10.1084/jem.20031547; PMCID=PMC2194160;
RA   Oh-hora M., Johmura S., Hashimoto A., Hikida M., Kurosaki T.;
RT   "Requirement for Ras guanine nucleotide releasing protein 3 in
RT   coupling phospholipase C-gamma2 to Ras in B cell receptor signaling.";
RL   J. Exp. Med. 198:1841-1851(2003).
//