ID   H7D7A
AC   CVCL_1T06
SY   H7D7-A
DR   BioSample; SAMN03151769
DR   cancercelllines; CVCL_1T06
DR   Wikidata; Q54872220
RX   PubMed=12619888;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a Hep-G2 derivative (PubMed=12619888; PubMed=20143388). Originally thought to originate from SV40-transformed normal liver cells.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00203.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
ST   Source(s): PubMed=12619888
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D16S539: 12,13
ST   D21S11: 29,31
ST   D3S1358: 15,16
ST   D7S820: 10
ST   TH01: 9
ST   TPOX: 8,9
ST   vWA: 17
DI   NCIt; C3728; Hepatoblastoma
DI   ORDO; Orphanet_449; Hepatoblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0027 ! Hep-G2
SX   Male
AG   15Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 20
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=12619888; DOI=10.1023/A:1021653506123;
RA   van Pelt, Jos F.
RA   Decorte, Ronny
RA   Yap, Paul S.H.
RA   Fevery, Johan
RT   "Identification of HepG2 variant cell lines by short tandem repeat
RT   (STR) analysis.";
RL   Mol. Cell. Biochem. 243:49-54(2003).
//