ID   OS 187
AC   CVCL_1R50
SY   OS-187; OS187
DR   BioSample; SAMN03151646
DR   cancercelllines; CVCL_1R50
DR   Wikidata; Q54936532
RX   PubMed=15026342;
RX   PubMed=18483362;
RX   PubMed=24046071;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HCT 15 derivative (PubMed=24046071). Originally thought to originate from an osteosarcoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00485.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Arg727Met (c.2180G>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Lys993Asn (c.2979G>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Ile1417Leufs*2 (c.4248delC); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Arg2166Ter (c.6496C>T); ClinVar=VCV000438883; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:914; B2M; Simple; c.68-1G>T; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:914; B2M; Simple; p.Tyr30Ter (c.90C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Cys1200Terfs (c.3599_3600delGT) (3827delGT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Asn1784Hisfs*7 (c.5350_5351delAA); ClinVar=VCV000037959; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16627; CHEK2; Simple; p.Arg145Trp (c.433C>T); ClinVar=VCV000005592; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Asp549Asn (c.1645G>A); ClinVar=VCV000375900; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Ser241Phe (c.722C>T); ClinVar=VCV000012359; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.1101-2A>C; ClinVar=VCV000635383; Zygosity=Heterozygous; Note=Splice acceptor mutation (from parent cell line).
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
CC   Cell type: Epithelial cell of colon; CL=CL_0011108.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0292 ! HCT 15
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 20
//
RX   PubMed=15026342; DOI=10.1158/0008-5472.CAN-03-3096;
RA   Hughes, Dennis Patrick Meehan
RA   Thomas, Dafydd G.
RA   Giordano, Thomas J.
RA   Baker, Laurence H.
RA   McDonagh, Kevin T.
RT   "Cell surface expression of epidermal growth factor receptor and Her-2
RT   with nuclear expression of Her-4 in primary osteosarcoma.";
RL   Cancer Res. 64:2047-2053(2004).
//
RX   PubMed=18483362; DOI=10.1158/1078-0432.CCR-07-1992; PMCID=PMC2830718;
RA   Zhang, Ping-Yu
RA   Yang, Yan-Wen
RA   Zweidler-McKay, Patrick A.
RA   Hughes, Dennis Patrick Meehan
RT   "Critical role of Notch signaling in osteosarcoma invasion and
RT   metastasis.";
RL   Clin. Cancer Res. 14:2962-2969(2008).
//
RX   PubMed=24046071; DOI=10.1158/1078-0432.CCR-13-1914; PMCID=PMC4375543;
RA   Zhang, Ping-Yu
RA   Yang, Yan-Wen
RA   Zweidler-McKay, Patrick A.
RA   Hughes, Dennis Patrick Meehan
RT   "Retraction to 'Critical role of Notch signaling in osteosarcoma invasion
RT   and metastasis'.";
RL   Clin. Cancer Res. 19:5256-5257(2013).
//