ID   C2 [Dog mastocytoma]
AC   CVCL_1R44
SY   C2-S
DR   GEO; GSM1974778
DR   Wikidata; Q54807886
RX   PubMed=1634619;
RX   PubMed=2121170;
RX   PubMed=2431625;
RX   PubMed=10210327;
RX   PubMed=19185923;
RX   PubMed=25190452;
RX   PubMed=26842912;
RX   PubMed=27197945;
RX   PubMed=27257868;
RX   PubMed=31175136;
CC   Part of: FACC canine tumor cell line panel.
CC   Doubling time: 49.3 +- 12.5 hours (PubMed=2121170); 21 hours (PubMed=27257868).
CC   Sequence variation: Mutation; VGNC; 54284; CCND3; Simple; p.Ala66_Ser67del (c.194_199delGCGCCA); Zygosity=Homozygous (PubMed=31175136).
CC   Sequence variation: Mutation; VGNC; 42422; KIT; Unexplicit; Tandem duplication of a 48bp sequence; Zygosity=Unspecified (PubMed=10210327).
CC   Sequence variation: Mutation; VGNC; 47719; TP53; Simple; p.Val162Ala (c.485T>C); Zygosity=Homozygous (PubMed=31175136).
CC   Omics: Deep exome analysis.
CC   Omics: Transcriptome analysis by microarray.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 231
ST   Dog FHC2054: 147,156
ST   Dog FHC2079: 271
ST   Dog PEZ1: 107,123
ST   Dog PEZ3: 115,119
ST   Dog PEZ5: 111
ST   Dog PEZ6: 183,187
ST   Dog PEZ8: 228,232
ST   Dog PEZ12: 270
ST   Dog PEZ20: 176,184
DI   NCIt; C129077; Canine mastocytoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 21-03-23; Version: 11
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RX   PubMed=1634619; DOI=10.1172/JCI115853; PMCID=PMC443060;
RA   Pennington D.W., Lopez A.R., Thomas P.S., Peck C., Gold W.M.;
RT   "Dog mastocytoma cells produce transforming growth factor beta 1.";
RL   J. Clin. Invest. 90:35-41(1992).
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RX   PubMed=2121170; DOI=10.1165/ajrcmb/3.5.413;
RA   DeVinney R., Gold W.M.;
RT   "Establishment of two dog mastocytoma cell lines in continuous
RT   culture.";
RL   Am. J. Respir. Cell Mol. Biol. 3:413-420(1990).
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RX   PubMed=2431625; DOI=10.1152/ajpcell.1986.251.6.C935;
RA   Lazarus S.C., DeVinney R., McCabe L.J., Finkbeiner W.E., Elias D.J.,
RA   Gold W.M.;
RT   "Isolated canine mastocytoma cells: propagation and characterization
RT   of two cell lines.";
RL   Am. J. Physiol. 251:C935-C944(1986).
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RX   PubMed=10210327; DOI=10.1016/S0301-472X(98)00075-7;
RA   London C.A., Galli S.J., Yuuki T., Hu Z.-Q., Helfand S.C.,
RA   Geissler E.N.;
RT   "Spontaneous canine mast cell tumors express tandem duplications in
RT   the proto-oncogene c-kit.";
RL   Exp. Hematol. 27:689-697(1999).
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RX   PubMed=19185923; DOI=10.1016/j.vetimm.2008.12.023;
RA   Elders R.C., Baines S.J., Catchpole B.;
RT   "Susceptibility of the C2 canine mastocytoma cell line to the effects
RT   of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).";
RL   Vet. Immunol. Immunopathol. 130:11-16(2009).
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RX   PubMed=25190452; DOI=10.1186/s12917-014-0184-9; PMCID=PMC4172958;
RA   Pang L.Y., Argyle S.A., Kamida A., Morrison K.O., Argyle D.J.;
RT   "The long-acting COX-2 inhibitor mavacoxib (Trocoxil TM) has
RT   anti-proliferative and pro-apoptotic effects on canine cancer cell
RT   lines and cancer stem cells in vitro.";
RL   BMC Vet. Res. 10:184.1-184.11(2014).
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RX   PubMed=26842912; DOI=10.1111/vco.12197;
RA   Hartley G., Faulhaber E.A., Caldwell A., Coy J., Kurihara J.N.,
RA   Guth A., Regan D.P., Dow S.W.;
RT   "Immune regulation of canine tumour and macrophage PD-L1 expression.";
RL   Vet. Comp. Oncol. 15:534-549(2017).
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RX   PubMed=27197945; DOI=10.1111/vco.12192; PMCID=PMC5656225;
RA   Fowles J.S., Dailey D.D., Gustafson D.L., Thamm D.H., Duval D.L.;
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
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RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608;
RA   Maeda J., Froning C.E., Brents C.A., Rose B.J., Thamm D.H., Kato T.A.;
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:E0156689-E0156689(2016).
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RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole-exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
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