ID   C2 [Dog mastocytoma]
AC   CVCL_1R44
SY   C2-S
DR   GEO; GSM1974778
DR   Wikidata; Q54807886
RX   PubMed=1634619;
RX   PubMed=2121170;
RX   PubMed=2431625;
RX   PubMed=10210327;
RX   PubMed=19185923;
RX   PubMed=25190452;
RX   PubMed=26842912;
RX   PubMed=27197945;
RX   PubMed=27257868;
RX   PubMed=31175136;
CC   Part of: FACC canine tumor cell line panel.
CC   Doubling time: 49.3 +- 12.5 hours (PubMed=2121170); 21 hours (PubMed=27257868).
CC   Sequence variation: Mutation; VGNC; VGNC:54284; CCND3; Simple; p.Ala66_Ser67del (c.194_199delGCGCCA); Zygosity=Homozygous (PubMed=31175136).
CC   Sequence variation: Mutation; VGNC; VGNC:42422; KIT; Unexplicit; Tandem duplication of a 48bp sequence; Zygosity=Unspecified (PubMed=10210327).
CC   Sequence variation: Mutation; VGNC; VGNC:47719; TP53; Simple; p.Val162Ala (c.485T>C); Zygosity=Homozygous (PubMed=31175136).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
ST   Source(s): PubMed=27197945; PubMed=31175136
ST   Dog FHC2010: 231
ST   Dog FHC2054: 147,156
ST   Dog FHC2079: 271
ST   Dog PEZ1: 107,123
ST   Dog PEZ3: 115,119
ST   Dog PEZ5: 111
ST   Dog PEZ6: 183,187
ST   Dog PEZ8: 228,232
ST   Dog PEZ12: 270
ST   Dog PEZ20: 176,184
DI   NCIt; C129077; Canine mastocytoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 13
//
RX   PubMed=26842912; DOI=10.1111/vco.12197;
RA   Hartley, Genevieve
RA   Faulhaber, Erica Ann
RA   Caldwell, Alison
RA   Coy, Jonathan
RA   Kurihara, Jade N.
RA   Guth, Amanda
RA   Regan, Daniel P.
RA   Dow, Steven W.
RT   "Immune regulation of canine tumour and macrophage PD-L1 expression.";
RL   Vet. Comp. Oncol. 15:534-549(2017).
//
RX   PubMed=2121170; DOI=10.1165/ajrcmb/3.5.413;
RA   DeVinney, Rebekah
RA   Gold, Warren M.
RT   "Establishment of two dog mastocytoma cell lines in continuous
RT   culture.";
RL   Am. J. Respir. Cell Mol. Biol. 3:413-420(1990).
//
RX   PubMed=10210327; DOI=10.1016/S0301-472X(98)00075-7;
RA   London, Cheryl A.
RA   Galli, Stephen Joseph
RA   Yuuki, Toshifumi
RA   Hu, Zhi-Qing
RA   Helfand, Stuart C.
RA   Geissler, Edwin N.
RT   "Spontaneous canine mast cell tumors express tandem duplications in
RT   the proto-oncogene c-kit.";
RL   Exp. Hematol. 27:689-697(1999).
//
RX   PubMed=19185923; DOI=10.1016/j.vetimm.2008.12.023;
RA   Elders, Richard Christopher
RA   Baines, Stephen J.
RA   Catchpole, Brian
RT   "Susceptibility of the C2 canine mastocytoma cell line to the effects
RT   of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).";
RL   Vet. Immunol. Immunopathol. 130:11-16(2009).
//
RX   PubMed=1634619; DOI=10.1172/JCI115853; PMCID=PMC443060;
RA   Pennington, Daniel W.
RA   Lopez, Alfredo R.
RA   Thomas, Paul S.
RA   Peck, Caroline
RA   Gold, Warren M.
RT   "Dog mastocytoma cells produce transforming growth factor beta 1.";
RL   J. Clin. Invest. 90:35-41(1992).
//
RX   PubMed=27197945; DOI=10.1111/vco.12192; PMCID=PMC5656225;
RA   Fowles, Jared S.
RA   Dailey, Deanna D.
RA   Gustafson, Daniel L.
RA   Thamm, Douglas H.
RA   Duval, Dawn L.
RT   "The Flint Animal Cancer Center (FACC) canine tumour cell line panel:
RT   a resource for veterinary drug discovery, comparative oncology and
RT   translational medicine.";
RL   Vet. Comp. Oncol. 15:481-492(2017).
//
RX   PubMed=27257868; DOI=10.1371/journal.pone.0156689; PMCID=PMC4892608;
RA   Maeda, Junko
RA   Froning, Coral Eva
RA   Brents, Colleen A.
RA   Rose, Barbara J.
RA   Thamm, Douglas H.
RA   Kato, Takamitsu A.
RT   "Intrinsic radiosensitivity and cellular characterization of 27 canine
RT   cancer cell lines.";
RL   PLoS ONE 11:e0156689.1-e0156689.18(2016).
//
RX   PubMed=25190452; DOI=10.1186/s12917-014-0184-9; PMCID=PMC4172958;
RA   Pang, Lisa Y.
RA   Argyle, Sally Anne
RA   Kamida, Ayako
RA   Morrison, Katherine O'Neill
RA   Argyle, David John
RT   "The long-acting COX-2 inhibitor mavacoxib (Trocoxil TM) has
RT   anti-proliferative and pro-apoptotic effects on canine cancer cell
RT   lines and cancer stem cells in vitro.";
RL   BMC Vet. Res. 10:184.1-184.11(2014).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748;
RA   Das, Sunetra
RA   Idate, Rupa
RA   Cronise, Kathryn E.
RA   Gustafson, Daniel L.
RA   Duval, Dawn L.
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole-exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//
RX   PubMed=2431625; DOI=10.1152/ajpcell.1986.251.6.C935;
RA   Lazarus, Stephen C.
RA   DeVinney, Rebekah
RA   McCabe, Laurence J.
RA   Finkbeiner, Walter E.
RA   Elias, Darlene J.
RA   Gold, Warren M.
RT   "Isolated canine mastocytoma cells: propagation and characterization
RT   of two cell lines.";
RL   Am. J. Physiol. 251:C935-C944(1986).
//