ID   HEL-R66
AC   CVCL_1R39
SY   HELR66
DR   BioSample; SAMN03152012
DR   Wikidata; Q54882507
RX   PubMed=116626;
RX   PubMed=218901;
RX   PubMed=6451928;
RX   PubMed=7236009;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Group: Non-human primate cell line.
CC   Problematic cell line: Misidentified. Originally thought to be an embryonic lung cell line of human origin but found to be from Chlorocebus aethiops (PubMed=6451928; PubMed=7236009; PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00065.
CC   Virology: Highly susceptible to infection by herpes simplex virus types 1 and 2, vaccinia virus, Newcastle disease virus (NDV), Japanese encephalitis virus (JEV), western equine encephalitis virus, Sindbis virus, vesicular stomatitis virus (VSV) and rabies virus (PubMed=116626; PubMed=218901).
OX   NCBI_TaxID=9534; ! Chlorocebus aethiops (Green monkey)
SX   Sex unspecified
AG   Age unspecified
CA   Undefined cell line type
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 13
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RX   PubMed=116626; DOI=10.1007/BF01317506;
RA   Taguchi F., Toba M., Tada A.;
RT   "Establishment of a permanent cell line (HEL-R66) from human embryonic
RT   lung cells with high susceptibility to viruses. Brief report.";
RL   Arch. Virol. 60:347-351(1979).
//
RX   PubMed=218901; DOI=10.1159/000149037;
RA   Toba M., Suzuki H., Sekine N.;
RT   "Absence of interferon production in a newly established human cell
RT   line.";
RL   Intervirology 11:221-226(1979).
//
RX   PubMed=6451928; DOI=10.1126/science.6451928;
RA   Nelson-Rees W.A., Daniels D.W., Flandermeyer R.R.;
RT   "Cross-contamination of cells in culture.";
RL   Science 212:446-452(1981).
//
RX   PubMed=7236009; DOI=10.1007/BF01314608;
RA   Nelson-Rees W.A., Daniels D.W., Flandermeyer R.R.;
RT   "Human embryonic lung cells (HEL-R66) are of monkey origin.";
RL   Arch. Virol. 67:101-104(1981).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A.,
RA   MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R.,
RA   Freshney R.I.;
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//