ID   NP-2
AC   CVCL_1R15
SY   NP 2; Case 4; NB3911
DR   cancercelllines; CVCL_1R15
DR   Cell_Model_Passport; SIDM01822
DR   DepMap; ACH-001608
DR   JCRB; JCRB1566
DR   RCB; RCB4498
DR   Wikidata; Q54930940
RX   CelloPub=CLPUB00260;
RX   DOI=10.2974/kmj.62.1;
RX   PubMed=8878451;
RX   PubMed=10551321;
RX   PubMed=18415661;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Japanese.
CC   Doubling time: 36 hours (Note=At 145th passage) (CelloPub=CLPUB00260).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met237Ile (c.711G>T); ClinVar=VCV000634770; Zygosity=Unspecified (PubMed=8878451).
CC   Derived from site: In situ; Brain, left frontal lobe; UBERON=UBERON_0002811.
ST   Source(s): DepMap=ACH-001608; JCRB=JCRB1566
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 10,12
ST   D16S539: 9,10,11
ST   D18S51: 13,15
ST   D21S11: 29
ST   D3S1358: 15,16
ST   D5S818: 11
ST   D7S820: 11
ST   D8S1179: 14,17
ST   FGA: 23
ST   Penta D: 12
ST   Penta E: 11
ST   TH01: 6
ST   TPOX: 8,11
ST   vWA: 16
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 18
CH   CVCL_1R19 ! NP-2/APJ
CH   CVCL_1R20 ! NP-2/CCR3
CH   CVCL_1R21 ! NP-2/CCR5
CH   CVCL_1R22 ! NP-2/CCR8
CH   CVCL_1R18 ! NP-2/CD4
CH   CVCL_1R23 ! NP-2/CXCR4
CH   CVCL_1R24 ! NP-2/GPR1
CH   CVCL_UE99 ! NP-2/iGFP
//
RX   CelloPub=CLPUB00260;
RA   Yamazaki, Kazunori
RT   "Tumorigenicity of established human glioma cell lines in lasat and
RT   nude mice.";
RL   Neuropathology 3:29-38(1982).
//
RX   PubMed=8878451; DOI=10.1111/j.1349-7006.1996.tb02118.x; PMCID=PMC5921198;
RA   Zhang, Shu-Jing
RA   Endo, Sumio
RA   Koga, Hisashi
RA   Ichikawa, Tomio
RA   Feng, Xue-Lian
RA   Onda, Kiyoshi
RA   Washiyama, Kazuo
RA   Kumanishi, Toshiro
RT   "A comparative study of glioma cell lines for p16, p15, p53 and p21
RT   gene alterations.";
RL   Jpn. J. Cancer Res. 87:900-907(1996).
//
RX   DOI=10.2974/kmj.62.1;
RA   Hoshino, Hiroo
RT   "The NP-2 cell system for analyses of the coreceptor usage of human
RT   and simian immunodeficiency viruses.";
RL   Kitakanto Med. J. 62:1-14(2012).
//
RX   PubMed=10551321; DOI=10.1111/j.1349-7006.1999.tb00838.x; PMCID=PMC5926156;
RA   Zhang, Shu-Jing
RA   Endo, Sumio
RA   Ichikawa, Tomio
RA   Yoshimura, Jun-ichi
RA   Onda, Kiyoshi
RA   Tanaka, Ryuichi
RA   Washiyama, Kazuo
RA   Kumanishi, Toshiro
RT   "Rare-type mutations of MMAC1 tumor suppressor gene in human glioma
RT   cell lines and their tumors of origin.";
RL   Jpn. J. Cancer Res. 90:934-941(1999).
//
RX   PubMed=18415661; DOI=10.1007/s10014-007-0226-0;
RA   Tanaka, Yoshiyuki
RA   Zhang, Shu-Jing
RA   Terasaki, Hiroshi
RA   Koga, Hisashi
RA   Endo, Sumio
RA   Usui, Hiroshi
RA   Washiyama, Kazuo
RA   Kumanishi, Toshiro
RA   Uematsu, Yuji
RA   Itakura, Toru
RT   "Frequent and variable abnormalities in p14 tumor suppressor gene in
RT   glioma cell lines.";
RL   Brain Tumor Pathol. 25:9-17(2008).
//