ID   CMMT-CD4-LTR-beta-Gal
AC   CVCL_1H34
SY   Simian MAGI; sMAGI; Simian Multinuclear Activation of a Galactosidase Indicator
DR   BEI_Resources; ARP-2955
DR   Wikidata; Q54813809
RX   PubMed=7491763;
CC   Group: Non-human primate cell line.
CC   Characteristics: Transfected with a construct pEQ447 containing the HIV-1 LTR fused to a lacZ reporter gene that contains a MPKKKRK N-terminal sequence directing it to the nucleus (PubMed=7491763).
CC   Virology: Indicator cell line that allows rapid quantification of infectious SIV (PubMed=7491763).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1678; CD4.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Transformant: NCBI_TaxID; 11855; Mason-Pfizer monkey virus (MPMV).
CC   Derived from site: In situ; Mammary gland; UBERON=UBERON_0001911.
DI   NCIt; C134784; Rhesus monkey mammary tumor
OX   NCBI_TaxID=9544; ! Macaca mulatta (Rhesus macaque)
HI   CVCL_E8AJ ! CMMT-CD4
SX   Female
AG   Adult
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 17
//
RX   PubMed=7491763; DOI=10.1006/viro.1995.0011;
RA   Chackerian B., Haigwood N.L., Overbaugh J.;
RT   "Characterization of a CD4-expressing macaque cell line that can
RT   detect virus after a single replication cycle and can be infected by
RT   diverse simian immunodeficiency virus isolates.";
RL   Virology 213:386-394(1995).
//