ID   EGFP-CEM-NKr
AC   CVCL_1G54
SY   EGFP-CEMNKR; EGFP-CEMNKr
DR   BEI_Resources; ARP-11698
DR   cancercelllines; CVCL_1G54
DR   Wikidata; Q54832083
RX   PubMed=16884734;
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_X622 ! CEM.NKR
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 20
//
RX   PubMed=16884734; DOI=10.1016/j.jim.2006.06.005;
RA   Kantakamalakul W., Pattanapanyasat K., Jongrakthaitae S.,
RA   Assawadarachai V., Ampol S., Sutthent R.;
RT   "A novel EGFP-CEM-NKr flow cytometric method for measuring antibody
RT   dependent cell mediated-cytotoxicity (ADCC) activity in HIV-1 infected
RT   individuals.";
RL   J. Immunol. Methods 315:1-10(2006).
//