ID   U373-MAGI-CCR5
AC   CVCL_1F85
SY   U373-MAGI-CCR5E
DR   BEI_Resources; ARP-3597
DR   Wikidata; Q54973738
RX   PubMed=9201229;
CC   Population: Caucasian.
CC   Characteristics: Transfected with a construct pEQ447 containing the HIV-1 LTR fused to a lacZ reporter gene that contains a MPKKKRK N-terminal sequence directing it to the nucleus (from a parent cell line).
CC   Virology: Can be used to detect primary isolates of HIV-1, HIV-2 and SIV (PubMed=9201229).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1606; CCR5.
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1678; CD4.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1F84 ! U373-MAGI
SX   Male
AG   75Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 12
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RX   PubMed=9201229; DOI=10.1006/viro.1997.8606;
RA   Vodicka M.A., Goh W.C., Wu L.I., Rogel M.E., Bartz S.R.,
RA   Schweickart V.L., Raport C.J., Emerman M.;
RT   "Indicator cell lines for detection of primary strains of human and
RT   simian immunodeficiency viruses.";
RL   Virology 233:193-198(1997).
//