ID   Rev-CEM
AC   CVCL_1E04
SY   RevCEM
DR   BEI_Resources; ARP-11467
DR   cancercelllines; CVCL_1E04
DR   Wikidata; Q54949797
RX   PubMed=17627502;
CC   Population: Caucasian.
CC   Characteristics: Transfected with a pNL-GFP-RRE(SA) construct that results in the expression of the GFP gene under the control of the HIV-1 LTR promoter in HIV-1 infected cells when Tat and Rev are present.
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_J318 ! CEM-SS
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 18
CH   CVCL_A9NQ ! Rev-CEM-D4
CH   CVCL_A9NR ! Rev-CEM-E7
//
RX   PubMed=17627502; DOI=10.2174/157016207781024018; PMCID=PMC2366165;
RA   Wu, Yun-Tao
RA   Beddall, Margaret H.
RA   Marsh, Jon W.
RT   "Rev-dependent indicator T cell line.";
RL   Curr. HIV Res. 5:394-402(2007).
//