ID   BC7
AC   CVCL_1E03
DR   BEI_Resources; ARP-11434
DR   cancercelllines; CVCL_1E03
DR   Wikidata; Q54795315
RX   PubMed=8929542;
RX   PubMed=11264379;
CC   Population: Caucasian.
CC   Characteristics: CD4 negative.
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Cys251Tyr (c.752G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6342; KIT; Simple; p.Arg177His (c.530G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7029; MET; Simple; p.Arg191Trp (c.571C>T); ClinVar=VCV000568557; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Asp (c.1635G>T); ClinVar=VCV000217293; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu970Lys (c.2908G>A); ClinVar=VCV001057635; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9585; PTCH1; Simple; p.Arg682Cys (c.2044C>T); ClinVar=VCV000237466; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:15533; SPRY4; Simple; p.Arg25Trp (c.73C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg267Leu (c.800G>T); ClinVar=VCV000852206; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7210; Childhood T lymphoblastic lymphoma
DI   ORDO; Orphanet_171918; T-cell non-Hodgkin lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1714 ! SUP-T1
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 16
CH   CVCL_ZX81 ! BC7/CCR5
//
RX   PubMed=11264379; DOI=10.1128/JVI.75.8.3903-3915.2001; PMCID=PMC114881;
RA   Means, Robert E.
RA   Matthews, Thomas
RA   Hoxie, James A.
RA   Malim, Michael Henry
RA   Kodama, Toshiaki
RA   Desrosiers, Ronald Charles
RT   "Ability of the V3 loop of simian immunodeficiency virus to serve as a
RT   target for antibody-mediated neutralization: correlation of
RT   neutralization sensitivity, growth in macrophages, and decreased
RT   dependence on CD4.";
RL   J. Virol. 75:3903-3915(2001).
//
RX   PubMed=8929542; DOI=10.1016/S0092-8674(00)81393-8;
RA   Endres, Michael J.
RA   Clapham, Paul R.
RA   Marsh, Mark
RA   Ahuja, Menaka
RA   Turner, Julie Davis
RA   McKnight, Aine
RA   Thomas, Jill F.
RA   Stoebenau-Haggarty, Beth
RA   Choe, Sunny
RA   Vance, Patricia J.
RA   Wells, Timothy Nigel Carl
RA   Power, Christine A.
RA   Sutterwala, Shaheen S.
RA   Doms, Robert W.
RA   Landau, Nathaniel R.
RA   Hoxie, James A.
RT   "CD4-independent infection by HIV-2 is mediated by fusin/CXCR4.";
RL   Cell 87:745-756(1996).
//