ID   UOK268
AC   CVCL_1D73
SY   UOK 268
DR   cancercelllines; CVCL_1D73
DR   Wikidata; Q54991421
RX   PubMed=21907923;
RX   PubMed=22867999;
RX   PubMed=27993170;
RX   PubMed=33402335;
WW   Provider; NIH OTT; E-254-2010/0-79; https://web.archive.org/web/20150923173311/http://www.ott.nih.gov/erma/one-1-vial-uok-268-hereditary-leiomyomatosis-and-renal-cell-carcinoma-hlrcc-human-cell-line
CC   Sequence variation: Mutation; HGNC; HGNC:3700; FH; Simple; p.His235Asp (c.703C>G); ClinVar=VCV000393569; Zygosity=Homozygous (PubMed=22867999; PubMed=33402335).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C51302; Hereditary leiomyomatosis and renal cell carcinoma
DI   ORDO; Orphanet_523; Hereditary leiomyomatosis and renal cell cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   26Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 11
//
RX   PubMed=21907923; DOI=10.1016/j.ccr.2011.07.018; PMCID=PMC3174047;
RA   Tong W.-H., Sourbier C., Kovtunovych G., Jeong S.Y., Vira M.A., Ghosh M.,
RA   Romero V.V., Sougrat R., Vaulont S., Viollet B., Kim Y.-S., Lee S.,
RA   Trepel J.B., Srinivasan R., Bratslavsky G., Yang Y.-F., Linehan W.M.,
RA   Rouault T.A.;
RT   "The glycolytic shift in fumarate-hydratase-deficient kidney cancer
RT   lowers AMPK levels, increases anabolic propensities and lowers
RT   cellular iron levels.";
RL   Cancer Cell 20:315-327(2011).
//
RX   PubMed=22867999; DOI=10.1016/j.cancergen.2012.05.001; PMCID=PMC3415708;
RA   Yang Y.-F., Valera V.A., Sourbier C., Vocke C.D., Wei M.-H., Pike L.,
RA   Huang Y., Merino M.J., Bratslavsky G., Wu M., Ricketts C.J.,
RA   Linehan W.M.;
RT   "A novel fumarate hydratase-deficient HLRCC kidney cancer cell line,
RT   UOK268: a model of the Warburg effect in cancer.";
RL   Cancer Genet. 205:377-390(2012).
//
RX   PubMed=27993170; DOI=10.1186/s12943-016-0565-8; PMCID=PMC5168717;
RA   Brodaczewska K.K., Szczylik C., Fiedorowicz M., Porta C.,
RA   Czarnecka A.M.;
RT   "Choosing the right cell line for renal cell cancer research.";
RL   Mol. Cancer 15:83.1-83.15(2016).
//
RX   PubMed=33402335; DOI=10.1126/scisignal.abc4436; PMCID=PMC8039187;
RA   Crooks D.R., Maio N., Lang M., Ricketts C.J., Vocke C.D., Gurram S.,
RA   Turan S., Kim Y.-Y., Cawthon G.M., Sohelian F., de Val N., Pfeiffer R.M.,
RA   Jailwala P., Tandon M., Tran B., Fan T.W.-M., Lane A.N., Ried T.,
RA   Wangsa Zong D., Malayeri A.A., Merino M.J., Yang Y.-F., Meier J.L.,
RA   Ball M.W., Rouault T.A., Srinivasan R., Linehan W.M.;
RT   "Mitochondrial DNA alterations underlie an irreversible shift to
RT   aerobic glycolysis in fumarate hydratase-deficient renal cancer.";
RL   Sci. Signal. 14:eabc4436.1-eabc4436.18(2021).
//