ID   UOK262
AC   CVCL_1D72
SY   UOK-262; UOK 262
DR   BTO; BTO_0005727
DR   Wikidata; Q54991416
RX   PubMed=19963135;
RX   PubMed=21907923;
RX   PubMed=22867999;
RX   PubMed=27993170;
RX   PubMed=33402335;
WW   Provider; NIH OTT; E-216-2008/0-28; https://web.archive.org/web/20150922090236/http://www.ott.nih.gov/erma/uok-262-hereditary-leiomyomatosis-and-renal-cell-carcinoma-hlrcc-cell-line
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; HGNC:3700; FH; Zygosity=Heterozygous; Note=Spontaneous loss of heterozygosity (PubMed=19963135; PubMed=33402335).
CC   Sequence variation: Mutation; HGNC; HGNC:3700; FH; Simple; p.Gln439Pro (c.1316A>C); ClinVar=VCV003230435; Zygosity=Heterozygous (PubMed=19963135; PubMed=33402335).
CC   Derived from site: Metastatic; Kidney; UBERON=UBERON_0002113.
DI   NCIt; C51302; Hereditary leiomyomatosis and renal cell carcinoma
DI   ORDO; Orphanet_523; Hereditary leiomyomatosis and renal cell cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   48Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 13
CH   CVCL_RN43 ! UOK262-WT
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RX   PubMed=27993170; DOI=10.1186/s12943-016-0565-8; PMCID=PMC5168717;
RA   Brodaczewska, Klaudia Klarysa
RA   Szczylik, Cezary
RA   Fiedorowicz, Michal
RA   Porta, Camillo
RA   Czarnecka, Anna Malgorzata
RT   "Choosing the right cell line for renal cell cancer research.";
RL   Mol. Cancer 15:83.1-83.15(2016).
//
RX   PubMed=22867999; DOI=10.1016/j.cancergen.2012.05.001; PMCID=PMC3415708;
RA   Yang, You-Feng
RA   Valera, Vladimir A.
RA   Sourbier, Carole
RA   Vocke, Cathy D.
RA   Wei, Ming-Hui
RA   Pike, Lisa
RA   Huang, Ying
RA   Merino, Maria J.
RA   Bratslavsky, Gennady
RA   Wu, Min
RA   Ricketts, Christopher J.
RA   Linehan, William Marston
RT   "A novel fumarate hydratase-deficient HLRCC kidney cancer cell line,
RT   UOK268: a model of the Warburg effect in cancer.";
RL   Cancer Genet. 205:377-390(2012).
//
RX   PubMed=33402335; DOI=10.1126/scisignal.abc4436; PMCID=PMC8039187;
RA   Crooks, Daniel R.
RA   Maio, Nunziata
RA   Lang, Martin
RA   Ricketts, Christopher J.
RA   Vocke, Cathy D.
RA   Gurram, Sandeep
RA   Turan, Sevilay
RA   Kim, Yun-Young
RA   Cawthon, Geetha Mariah
RA   Sohelian, Ferri
RA   de Val, Natalia
RA   Pfeiffer, Ruth Maria
RA   Jailwala, Parthav
RA   Tandon, Mayank
RA   Tran, Bao
RA   Fan, Teresa Whei-Mei
RA   Lane, Andrew N.
RA   Ried, Thomas
RA   Wangsa Zong, Darawalee
RA   Malayeri, Ashkan A.
RA   Merino, Maria J.
RA   Yang, You-Feng
RA   Meier, Jordan L.
RA   Ball, Mark W.
RA   Rouault, Tracey Ann
RA   Srinivasan, Ramaprasad
RA   Linehan, William Marston
RT   "Mitochondrial DNA alterations underlie an irreversible shift to
RT   aerobic glycolysis in fumarate hydratase-deficient renal cancer.";
RL   Sci. Signal. 14:eabc4436.1-eabc4436.18(2021).
//
RX   PubMed=19963135; DOI=10.1016/j.cancergencyto.2009.08.018; PMCID=PMC2827193;
RA   Yang, You-Feng
RA   Valera, Vladimir A.
RA   Padilla-Nash, Hesed Maria
RA   Sourbier, Carole
RA   Vocke, Cathy D.
RA   Vira, Manish A.
RA   Abu-Asab, Mones S.
RA   Bratslavsky, Gennady
RA   Tsokos, Maria G.
RA   Merino, Maria J.
RA   Pinto, Peter A.
RA   Srinivasan, Ramaprasad
RA   Ried, Thomas
RA   Neckers, Leonard Marshall
RA   Linehan, William Marston
RT   "UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary
RT   leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an
RT   aberrant energy metabolic pathway in human cancer.";
RL   Cancer Genet. Cytogenet. 196:45-55(2010).
//
RX   PubMed=21907923; DOI=10.1016/j.ccr.2011.07.018; PMCID=PMC3174047;
RA   Tong, Wing-Hang
RA   Sourbier, Carole
RA   Kovtunovych, Gennady
RA   Jeong, Suh Young
RA   Vira, Manish A.
RA   Ghosh, Manik
RA   Romero, Vladimir Valera
RA   Sougrat, Rachid
RA   Vaulont, Sophie
RA   Viollet, Benoit
RA   Kim, Yeong-Sang
RA   Lee, Sunmin
RA   Trepel, Jane B.
RA   Srinivasan, Ramaprasad
RA   Bratslavsky, Gennady
RA   Yang, You-Feng
RA   Linehan, William Marston
RA   Rouault, Tracey Ann
RT   "The glycolytic shift in fumarate-hydratase-deficient kidney cancer
RT   lowers AMPK levels, increases anabolic propensities and lowers
RT   cellular iron levels.";
RL   Cancer Cell 20:315-327(2011).
//