ID   U-CH10
AC   CVCL_1D66
SY   UCH10
DR   cancercelllines; CVCL_1D66
DR   Cosmic; 2663860
DR   GEO; GSM1673855
DR   GEO; GSM1673856
DR   Wikidata; Q54973612
RX   PubMed=26183925;
RX   PubMed=27102572;
RX   PubMed=28515451;
CC   Doubling time: 14 days (PubMed=26183925).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro72Arg (c.215C>G); ClinVar=VCV000012351; Zygosity=Unspecified (PubMed=28515451).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Bone, sacrum; UBERON=UBERON_0003690.
ST   Source(s): PubMed=26183925; PubMed=27102572
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 9,13
ST   D16S539: 11,13
ST   D18S51: 13
ST   D19S433: 13,15
ST   D21S11: 29,31
ST   D2S1338: 19
ST   D3S1358: 15,16
ST   D5S818: 11
ST   D7S820: 9,10 (PubMed=26183925)
ST   D7S820: 10 (PubMed=27102572)
ST   D8S1179: 8,13
ST   FGA: 24
ST   Penta D: 9,13
ST   Penta E: 18
ST   TH01: 8,9
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C129927; Sacral chordoma
DI   ORDO; Orphanet_178; Chordoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   75Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 16
//
RX   PubMed=27102572; DOI=10.1002/path.4729; PMCID=PMC4922416;
RA   Scheipl, Susanne
RA   Barnard, Michelle
RA   Cottone, Lucia
RA   Jorgensen, Mette
RA   Drewry, David Harold
RA   Zuercher, William J.
RA   Turlais, Fabrice
RA   Ye, Hong-Tao
RA   Leite, Ana P.
RA   Smith, James A.
RA   Leithner, Andreas
RA   Moller, Peter
RA   Bruderlein, Silke
RA   Guppy, Naomi
RA   Amary, Fernanda
RA   Tirabosco, Roberto
RA   Strauss, Sandra J.
RA   Pillay, Nischalan
RA   Flanagan, Adrienne M.
RT   "EGFR inhibitors identified as a potential treatment for chordoma in a
RT   focused compound screen.";
RL   J. Pathol. 239:320-334(2016).
//
RX   PubMed=28515451; DOI=10.1038/s41598-017-02174-5; PMCID=PMC5435709;
RA   Jager, Daniela
RA   Barth, Thomas F.E.
RA   Bruderlein, Silke
RA   Scheuerle, Angelika
RA   Rinner, Beate
RA   von Witzleben, Adrian
RA   Lechel, Andre
RA   Meyer, Patrick
RA   Mayer-Steinacker, Regine
RA   von Baer, Alexandra
RA   Schultheiss, Markus
RA   Wirtz, Christian R.
RA   Moller, Peter
RA   Mellert, Kevin
RT   "HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and
RT   sacral chordomas.";
RL   Sci. Rep. 7:2032-2032(2017).
//
RX   PubMed=26183925; DOI=10.1158/0008-5472.CAN-14-3270;
RA   von Witzleben, Adrian
RA   Goerttler, Lukas T.
RA   Marienfeld, Ralf
RA   Barth, Holger
RA   Lechel, Andre
RA   Mellert, Kevin
RA   Bohm, Michael
RA   Kornmann, Marko
RA   Mayer-Steinacker, Regine
RA   von Baer, Alexandra
RA   Schultheiss, Markus
RA   Flanagan, Adrienne M.
RA   Moller, Peter
RA   Bruderlein, Silke
RA   Barth, Thomas F.E.
RT   "Preclinical characterization of novel chordoma cell systems and their
RT   targeting by pharmocological inhibitors of the CDK4/6 cell-cycle
RT   pathway.";
RL   Cancer Res. 75:3823-3831(2015).
//