ID   2C4 [Human fibrosarcoma]
AC   CVCL_1D50
DR   cancercelllines; CVCL_1D50
DR   CancerTools; 154235
DR   Wikidata; Q54584423
DR   Ximbio; 154235
RX   PubMed=7901766;
RX   PubMed=9001223;
CC   Population: Caucasian.
CC   Characteristics: Expression of CD2 is under the control of the IFITM1 promoter inducible by interferon gamma.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1639; CD2.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
DI   NCIt; C3043; Fibrosarcoma
DI   ORDO; Orphanet_2030; Fibrosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0317 ! HT-1080
SX   Male
AG   35Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 14-08-25; Version: 20
CH   CVCL_C0D3 ! 2C4 gamma1A
CH   CVCL_C0D4 ! 2C4 gamma2A
//
RX   PubMed=7901766; DOI=10.1038/366166a0;
RA   Watling, Diane
RA   Guschin, Dmitry Y.
RA   Muller, Mathias
RA   Silvennoinen, Olli
RA   Witthuhn, Bruce A.
RA   Quelle, Frederick W.
RA   Rogers, Neil C.
RA   Schindler, Chris
RA   Stark, George Robert
RA   Ihle, James N.
RA   Kerr, Ian Macpherson
RT   "Complementation by the protein tyrosine kinase JAK2 of a mutant cell
RT   line defective in the interferon-gamma signal transduction pathway.";
RL   Nature 366:166-170(1993).
//
RX   PubMed=9001223; DOI=10.1128/mcb.17.2.695; PMCID=PMC231795;
RA   Kohlhuber, Franz
RA   Rogers, Neil C.
RA   Watling, Diane
RA   Feng, Jian
RA   Guschin, Dmitry Y.
RA   Briscoe, James
RA   Witthuhn, Bruce A.
RA   Kotenko, Serguei V.
RA   Pestka, Sidney
RA   Stark, George Robert
RA   Ihle, James N.
RA   Kerr, Ian Macpherson
RT   "A JAK1/JAK2 chimera can sustain alpha and gamma interferon
RT   responses.";
RL   Mol. Cell. Biol. 17:695-706(1997).
//