ID   MCF7 AREc32
AC   CVCL_1D32
SY   AREc32
DR   ABM; T6103
DR   cancercelllines; CVCL_1D32
DR   CancerTools; 151014
DR   ECACC; 16071902
DR   Wikidata; Q54750439
DR   Ximbio; 151014
RX   PubMed=17108137;
RX   PubMed=23032559;
WW   http://www.cxrbiosciences.com/technologies/arec32-cell-line/
CC   Population: Caucasian.
CC   Characteristics: Transfected with a construct containing 8 copies of the rat glutathione-S-transferase (GST) antioxidant response element (ARE) linked to the luciferase reporter gene. Induction of the ARE results in luciferase activity (PubMed=17108137).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: UniProtKB; P08659; Firefly luciferase.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): ECACC
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 14
ST   D21S11: 30
ST   D3S1358: 16
ST   D5S818: 11,12
ST   D7S820: 9
ST   D8S1179: 10,14
ST   FGA: 23,25
ST   Penta D: 12
ST   Penta E: 7,12
ST   TH01: 6
ST   TPOX: 9,12
ST   vWA: 14,15
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0031 ! MCF-7
SX   Female
AG   69Y
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 30-01-24; Version: 17
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RX   PubMed=17108137; DOI=10.1158/0008-5472.CAN-06-2298;
RA   Wang X.-J., Hayes J.D., Wolf C.R.;
RT   "Generation of a stable antioxidant response element-driven reporter
RT   gene cell line and its use to show redox-dependent activation of nrf2
RT   by cancer chemotherapeutic agents.";
RL   Cancer Res. 66:10983-10994(2006).
//
RX   PubMed=23032559; DOI=10.1039/c2em30506b;
RA   Escher B.I., Dutt M., Maylin E., Tang J.Y.M., Toze S., Wolf C.R.,
RA   Lang M.;
RT   "Water quality assessment using the AREc32 reporter gene assay
RT   indicative of the oxidative stress response pathway.";
RL   J. Environ. Monit. 14:2877-2885(2012).
//