ID   CEM/VM-1
AC   CVCL_1B35
SY   CEM/VM1; CEM-VM1
DR   cancercelllines; CVCL_1B35
DR   ChEMBL-Cells; CHEMBL3307511
DR   ChEMBL-Targets; CHEMBL614030
DR   PubChem_Cell_line; CVCL_1B35
DR   Wikidata; Q54809287
RX   PubMed=2888532;
RX   PubMed=3469013;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_75988; Teniposide (VM-26).
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0207 ! CCRF-CEM
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 19-12-24; Version: 19
//
RX   PubMed=3469013;
RA   Danks, Mary K.
RA   Yalowich, Jack Charles
RA   Beck, William T.
RT   "Atypical multiple drug resistance in a human leukemic cell line
RT   selected for resistance to teniposide (VM-26).";
RL   Cancer Res. 47:1297-1301(1987).
//
RX   PubMed=2888532;
RA   Beck, William T.
RA   Cirtain, Margaret Cook
RA   Danks, Mary K.
RA   Felsted, Ronald LaNay
RA   Safa, Ahmad R.
RA   Wolverton, Judith Singer
RA   Suttle, D. Parker
RA   Trent, Jeffrey M.
RT   "Pharmacological, molecular, and cytogenetic analysis of 'atypical'
RT   multidrug-resistant human leukemic cells.";
RL   Cancer Res. 47:5455-5460(1987).
//