ID   COLO 699
AC   CVCL_1992
SY   COLO-699; Colo-699; COLO #699; Colo699; COLO699; Colorado 699; CHL1DM
DR   BTO; BTO_0003017
DR   CLO; CLO_0002574
DR   EFO; EFO_0006374
DR   CLDB; cl868
DR   ArrayExpress; E-MTAB-2706
DR   BioSample; SAMN03473074
DR   BioSample; SAMN10989575
DR   cancercelllines; CVCL_1992
DR   Cell_Model_Passport; SIDM00911
DR   Cosmic; 844591
DR   Cosmic; 877394
DR   Cosmic; 1028946
DR   Cosmic; 1146950
DR   Cosmic; 1152489
DR   DepMap; ACH-001041
DR   DSMZ; ACC-196
DR   DSMZCellDive; ACC-196
DR   EGA; EGAS00001000610
DR   GEO; GSM434300
DR   GEO; GSM886946
DR   GEO; GSM888014
DR   IGRhCellID; COLO699GEO
DR   PharmacoDB; COLO699_230_2019
DR   PRIDE; PXD002556
DR   Progenetix; CVCL_1992
DR   Wikidata; Q54814138
RX   PubMed=10908148;
RX   PubMed=11668190;
RX   PubMed=22460905;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26361996;
RX   PubMed=26589293;
RX   PubMed=31068700;
CC   Problematic cell line: Contaminated. Shown to be a CHL-1 (or RPMI-7932) derivative (DSMZ=ACC-196; DepMap=ACH-001041). Originally thought to originate from the pleural effusion of a 57 year old female patient with lung adenocarcinoma.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: ~38 hours (DSMZ=ACC-196).
CC   HLA typing: A*02:01,02:01; B*07:02,37:04; C*06:02,07:02 (PubMed=26589293).
CC   Sequence variation: Gene fusion; HGNC; HGNC:2352; CREM + HGNC; HGNC:3508; EWSR1; Name(s)=EWSR1-CREM (DepMap=ACH-001041).
CC   Sequence variation: Mutation; HGNC; HGNC:6877; MAPK3; Simple; p.Ile228Val (c.682A>G); Zygosity=Heterozygous (DepMap=ACH-001041).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (DepMap=ACH-001041).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: DSMZ; ACC-196; true.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): DSMZ=ACC-196; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D13S317: 11
ST   D16S539: 12
ST   D18S51: 11,12
ST   D19S433: 15
ST   D21S11: 29,30
ST   D2S1338: 18
ST   D3S1358: 15,17
ST   D5S818: 11,12
ST   D7S820: 11,13
ST   D8S1179: 10,13
ST   FGA: 23
ST   Penta D: 12,14
ST   Penta E: 10,13
ST   TH01: 9,9.3
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1122 ! CHL-1
SX   Female
AG   36Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 32
//
RX   PubMed=10908148; DOI=10.1038/labinvest.3780108;
RA   Speicher M.R., Petersen S., Uhrig S., Jentsch I., Fauth C., Eils R.,
RA   Petersen I.;
RT   "Analysis of chromosomal alterations in non-small cell lung cancer by
RT   multiplex-FISH, comparative genomic hybridization, and multicolor bar
RT   coding.";
RL   Lab. Invest. 80:1031-1041(2000).
//
RX   PubMed=11668190; DOI=10.1177/002215540104901105;
RA   Quentmeier H., Osborn M., Reinhardt J., Zaborski M., Drexler H.G.;
RT   "Immunocytochemical analysis of cell lines derived from solid
RT   tumors.";
RL   J. Histochem. Cytochem. 49:1369-1378(2001).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26361996; DOI=10.1016/j.jprot.2015.09.003;
RA   Grundner-Culemann K., Dybowski J.N., Klammer M., Tebbe A., Schaab C.,
RA   Daub H.;
RT   "Comparative proteome analysis across non-small cell lung cancer cell
RT   lines.";
RL   J. Proteomics 130:1-10(2016).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//