ID   A2780ADR
AC   CVCL_1941
SY   A2780-ADR; A2780 ADR
DR   CLO; CLO_0001572
DR   BioGRID_ORCS_Cell_line; 826
DR   cancercelllines; CVCL_1941
DR   CancerTools; 152707
DR   Cell_Model_Passport; SIDM01211
DR   ChEMBL-Cells; CHEMBL3988401
DR   Cosmic; 1139224
DR   ECACC; 93112520
DR   GEO; GSM827329
DR   GEO; GSM1291127
DR   LINCS_LDP; LCL-1694
DR   Progenetix; CVCL_1941
DR   PubChem_Cell_line; CVCL_1941
DR   Wikidata; Q54606613
DR   Ximbio; 152707
RX   PubMed=11416159;
RX   PubMed=20215515;
RX   PubMed=25230021;
RX   PubMed=30971826;
CC   Part of: OCCP ovarian cancer cell line panel.
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Discontinued: ECACC; 93112520; true.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
ST   Source(s): ECACC=93112520; PubMed=11416159; PubMed=25230021
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 13
ST   D16S539: 11,14
ST   D18S51: 15
ST   D19S433: 12
ST   D21S11: 28
ST   D2S1338: 21,22
ST   D3S1358: 14,16
ST   D5S818: 11,12
ST   D7S820: 10
ST   D8S1179: 14,15,16,17 (PubMed=25230021)
ST   D8S1179: 15,16,17 (PubMed=11416159)
ST   FGA: 19,25
ST   Penta D: 8,9
ST   Penta E: 10,13
ST   TH01: 6 (ECACC=93112520; PubMed=25230021)
ST   TH01: 6,9.3 (PubMed=11416159)
ST   TPOX: 8,9
ST   vWA: 15,16
DI   NCIt; C7979; Ovarian endometrioid adenocarcinoma
DI   ORDO; Orphanet_454723; Endometrioid carcinoma of ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0134 ! A2780
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 29
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545;
RA   Beaufort, Corine M.
RA   Helmijr, Jean C.A.
RA   Piskorz, Anna M.
RA   Hoogstraat, Marlous
RA   Ruigrok-Ritstier, Kirsten
RA   Besselink, Nicolle
RA   Murtaza, Muhammed
RA   van IJcken, Wilfred F.J.
RA   Heine, Anouk A.J.
RA   Smid, Marcel
RA   Koudijs, Marco J.
RA   Brenton, James D.
RA   Berns, Els M.J.J.
RA   Helleman, Jozien
RT   "Ovarian cancer cell line panel (OCCP): clinical importance of in
RT   vitro morphological subtypes.";
RL   PLoS ONE 9:e103988.1-e103988.16(2014).
//
RX   PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459;
RA   Masters, John R.W.
RA   Thomson, Jim A.
RA   Daly-Burns, Bernadette
RA   Reid, Yvonne A.
RA   Dirks, Wilhelm Gerhard
RA   Packer, Phil
RA   Toji, Lorraine Hellenga
RA   Ohno, Tadao
RA   Tanabe, Hideyuki
RA   Arlett, Colin Francis
RA   Kelland, Lloyd R.
RA   Harrison, Maureen
RA   Virmani, Arvind K.
RA   Ward, Timothy H.
RA   Ayres, Karen L.
RA   Debenham, Paul G.
RT   "Short tandem repeat profiling provides an international reference
RT   standard for human cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//