ID   AV3
AC   CVCL_1904
SY   AV 3; AV-3
DR   CLO; CLO_0001771
DR   CLO; CLO_0001772
DR   CLO; CLO_0001773
DR   CLDB; cl298
DR   CLDB; cl299
DR   ATCC; CCL-21
DR   BioSample; SAMN03151665
DR   BioSample; SAMN03471470
DR   ECACC; 88102402
DR   IZSLER; BS CL 3
DR   KCLB; 10021
DR   Wikidata; Q54751895
RX   DOI=10.1007/BF02618370;
RX   PubMed=1246601;
RX   PubMed=4864103;
RX   PubMed=5641128;
RX   PubMed=5668122;
RX   PubMed=14185313;
RX   PubMed=20143388;
RX   PubMed=23925245;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=4864103; PubMed=5641128; PubMed=1246601; PubMed=20143388). Originally thought to originate from a normal amnion.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00001.
CC   Population: African American.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Genomics; Whole genome sequencing; Low read coverage.
CC   Discontinued: KCLB; 10021; probable.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): ATCC=CCL-21; ECACC=88102402; IZSLER=BS CL 3
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D13S317: 13.3 (ATCC=CCL-21)
ST   D13S317: 14 (ECACC=88102402; IZSLER=BS CL 3)
ST   D16S539: 9,10
ST   D18S51: 15,16
ST   D19S433: 13,14
ST   D21S11: 27,28
ST   D2S1338: 17
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D7S820: 12
ST   D8S1179: 12,13
ST   FGA: 18,21
ST   Penta D: 8,15
ST   Penta E: 7,17
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 28
CH   CVCL_A5VW ! F-49-1
//
RX   PubMed=14185313; DOI=10.1126/science.146.3641.241;
RG   Cell Culture Collection Committee;
RT   "Animal cell strains. The Cell Culture Collection Committee has
RT   assembled and certified 23 strains of animal cells.";
RL   Science 146:241-243(1964).
//
RX   PubMed=5641128; DOI=10.1038/217750a0;
RA   Gartler, Stanley Michael
RT   "Apparent Hela cell contamination of human heteroploid cell lines.";
RL   Nature 217:750-751(1968).
//
RX   PubMed=1246601; DOI=10.1126/science.1246601;
RA   Nelson-Rees, Walter Anthony
RA   Flandermeyer, Robert R.
RT   "HeLa cultures defined.";
RL   Science 191:96-98(1976).
//
RX   DOI=10.1007/BF02618370;
RA   Stulberg, Cyril S.
RA   Coriell, Lewis Lemon
RA   Kniazeff, Alexis John
RA   Shannon, John E.
RT   "The animal cell culture collection.";
RL   In Vitro 5:1-16(1970).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=4864103;
RA   Gartler, Stanley Michael
RT   "Genetic markers as tracers in cell culture.";
RL   Natl. Cancer Inst. Monogr. 26:167-195(1967).
//
RX   PubMed=23925245; DOI=10.1038/nature12064; PMCID=PMC3740412;
RA   Adey, Andrew C.
RA   Burton, Joshua N.
RA   Kitzman, Jacob O.
RA   Hiatt, Joseph B.
RA   Lewis, Alexandra P.
RA   Martin, Beth K.
RA   Qiu, Ruo-Lan
RA   Lee, Choli
RA   Shendure, Jay
RT   "The haplotype-resolved genome and epigenome of the aneuploid HeLa
RT   cancer cell line.";
RL   Nature 500:207-211(2013).
//
RX   PubMed=5668122; DOI=10.3181/00379727-128-33119;
RA   Peterson, Ward Davis Jr.
RA   Stulberg, Cyril S.
RA   Swanborg, N.K.
RA   Robinson, Andria Rasile
RT   "Glucose-6-phosphate dehydrogenase isoenzymes in human cell cultures
RT   determined by sucrose-agar gel and cellulose acetate zymograms.";
RL   Proc. Soc. Exp. Biol. Med. 128:772-776(1968).
//