ID   UPCI-SCC-090
AC   CVCL_1899
SY   UPCI-SCC-90; UPCI:SCC090; UPCI:SCC90; UPCI-SCC090; UPCISCC090; SCC090; SCC90
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-3239
DR   BioGRID_ORCS_Cell_line; 1007
DR   BioSample; SAMN03473425
DR   Cell_Model_Passport; SIDM00399
DR   Cosmic; 1122679
DR   Cosmic; 1530750
DR   Cosmic; 2296310
DR   Cosmic-CLP; 1299052
DR   DepMap; ACH-001227
DR   DSMZ; ACC-670
DR   DSMZCellDive; ACC-670
DR   EGA; EGAS00001000978
DR   GDSC; 1299052
DR   GEO; GSM937832
DR   GEO; GSM937833
DR   PharmacoDB; SCC90_1357_2019
DR   PRIDE; PXD030304
DR   Wikidata; Q54991658
RX   PubMed=17112776;
RX   PubMed=17681875;
RX   PubMed=17848307;
RX   PubMed=20215515;
RX   PubMed=23419152;
RX   PubMed=24201445;
RX   PubMed=24403267;
RX   PubMed=25275298;
RX   PubMed=27397505;
RX   PubMed=28236344;
RX   PubMed=29156801;
RX   PubMed=30894373;
RX   PubMed=30971826;
RX   PubMed=33802339;
RX   PubMed=35839778;
WW   Provider; AHNS; -; https://www.ahns.info/view/research-cell-lines-view/entry/24336/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: OPC-22 oral and pharyngeal cancer cell line panel.
CC   Population: Caucasian.
CC   Virology: Contains from 100 to 500 copies of the HPV16 genome (PubMed=24201445).
CC   Doubling time: 2.8 days (PubMed=29156801); ~120-150 hours (DSMZ=ACC-670).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=3.18%; East Asian, South=0%; South Asian=0%; European, North=67.02%; European, South=29.79% (PubMed=30894373).
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
ST   Source(s): ATCC=CRL-3239; Cosmic-CLP=1299052; DepMap=ACH-001227; DSMZ=ACC-670; PubMed=25275298; PubMed=29156801; PubMed=33802339
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 12,13
ST   D18S51: 14,17 (DSMZ=ACC-670)
ST   D18S51: 14,18 (DepMap=ACH-001227; PubMed=25275298; PubMed=33802339)
ST   D19S433: 13
ST   D21S11: 29,31
ST   D2S1338: 22
ST   D3S1358: 14
ST   D5S818: 11,12
ST   D7S820: 9,10
ST   D8S1179: 12
ST   FGA: 20
ST   Penta D: 11
ST   Penta E: 11,12
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_C058 ! UPCI-SCC-152
SX   Male
AG   46Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 33
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=25275298; DOI=10.18632/oncotarget.2417; PMCID=PMC4253406;
RA   Martin, Daniel
RA   Abba, Martin Carlos
RA   Molinolo, Alfredo Alberto
RA   Vitale-Cross, Lynn
RA   Wang, Zhi-Yong
RA   Zaida, Moraima
RA   Delic, Naomi C.
RA   Samuels, Yardena
RA   Lyons, J. Guy
RA   Gutkind, Jorge Silvio
RT   "The head and neck cancer cell oncogenome: a platform for the
RT   development of precision molecular therapies.";
RL   Oncotarget 5:8906-8923(2014).
//
RX   PubMed=17848307; DOI=10.1016/j.ijrobp.2007.04.082;
RA   Yarbrough, Wendell Gray
RA   Whigham, Amy
RA   Brown, Brandee
RA   Roach, Michael
RA   Slebos, Robbert J.C.
RT   "Phosphoinositide kinase-3 status associated with presence or absence
RT   of human papillomavirus in head and neck squamous cell carcinomas.";
RL   Int. J. Radiat. Oncol. Biol. Phys. 69:S98-S101(2007).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174; PMCID=PMC5689691;
RA   Kalu, Nene N.
RA   Mazumdar, Tuhina
RA   Peng, Shao-Hua
RA   Shen, Li
RA   Sambandam, Vaishnav
RA   Rao, Xia-Yu
RA   Xi, Yuan-Xin
RA   Li, Le-Rong
RA   Qi, Yuan
RA   Gleber-Netto, Frederico O.
RA   Patel, Ameeta
RA   Wang, Jing
RA   Frederick, Mitchell J.
RA   Myers, Jeffrey N.
RA   Pickering, Curtis R.
RA   Johnson, Faye M.
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=33802339; DOI=10.3390/cancers13051069; PMCID=PMC7959143;
RA   Gottgens, Eva-Leonne
RA   Ansems, Marleen
RA   Leenders, William P.J.
RA   Bussink, Johan
RA   Span, Paul N.
RT   "Genotyping and characterization of HPV status, hypoxia, and
RT   radiosensitivity in 22 head and neck cancer cell lines.";
RL   Cancers (Basel) 13:1069.1-1069.12(2021).
//
RX   PubMed=17681875; DOI=10.1016/j.oraloncology.2007.05.003; PMCID=PMC2362065;
RA   Martin, Christa Lese
RA   Reshmi, Shalini C.
RA   Ried, Thomas
RA   Gottberg, William
RA   Wilson, John W.
RA   Reddy, Jaya K.
RA   Khanna, Poornima
RA   Johnson, Jonas T.
RA   Myers, Eugene Nicholas
RA   Gollin, Susanne M.
RT   "Chromosomal imbalances in oral squamous cell carcinoma: examination
RT   of 31 cell lines and review of the literature.";
RL   Oral Oncol. 44:369-382(2008).
//
RX   PubMed=24403267; DOI=10.1002/cam4.151; PMCID=PMC3892398;
RA   Kawakami, Hisato
RA   Okamoto, Isamu
RA   Terao, Kyoichi
RA   Sakai, Kazuko
RA   Suzuki, Minoru
RA   Ueda, Shinya
RA   Tanaka, Kaoru
RA   Kuwata, Kiyoko
RA   Morita, Yume
RA   Ono, Koji
RA   Nishio, Kazuto
RA   Nishimura, Yasumasa
RA   Doi, Katsumi
RA   Nakagawa, Kazuhiko
RT   "Human papillomavirus DNA and p16 expression in Japanese patients with
RT   oropharyngeal squamous cell carcinoma.";
RL   Cancer Med. 2:933-941(2013).
//
RX   PubMed=17112776; DOI=10.1016/j.oraloncology.2006.09.001; PMCID=PMC2025692;
RA   White, Jason S.
RA   Weissfeld, Joel L.
RA   Ragin, Camille C.R.
RA   Rossie, Karen M.
RA   Martin, Christa Lese
RA   Shuster, Michele
RA   Ishwad, Chandramohan S.
RA   Law, John C.
RA   Myers, Eugene Nicholas
RA   Johnson, Jonas T.
RA   Gollin, Susanne M.
RT   "The influence of clinical and demographic risk factors on the
RT   establishment of head and neck squamous cell carcinoma cell lines.";
RL   Oral Oncol. 43:701-712(2007).
//
RX   PubMed=30971826; DOI=10.1038/s41586-019-1103-9;
RA   Behan, Fiona M.
RA   Iorio, Francesco
RA   Picco, Gabriele
RA   Goncalves, Emanuel
RA   Beaver, Charlotte M.
RA   Migliardi, Giorgia
RA   Santos, Rita
RA   Rao, Yanhua
RA   Sassi, Francesco
RA   Pinnelli, Marika
RA   Ansari, Rizwan
RA   Harper, Sarah
RA   Jackson, David Adam
RA   McRae, Rebecca
RA   Pooley, Rachel
RA   Wilkinson, Piers
RA   van der Meer, Dieudonne J.
RA   Dow, David
RA   Buser-Doepner, Carolyn A.
RA   Bertotti, Andrea
RA   Trusolino, Livio
RA   Stronach, Euan Alexander
RA   Saez-Rodriguez, Julio
RA   Yusa, Kosuke
RA   Garnett, Mathew J.
RT   "Prioritization of cancer therapeutic targets using CRISPR-Cas9
RT   screens.";
RL   Nature 568:511-516(2019).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=23419152; DOI=10.1186/gm419; PMCID=PMC3706778;
RA   Lechner, Matthias
RA   Fenton, Tim R.
RA   West, James
RA   Wilson, Gareth
RA   Feber, Andrew
RA   Henderson, Stephen
RA   Thirlwell, Christina
RA   Dibra, Harpreet K.
RA   Jay, Amrita
RA   Butcher, Lee M.
RA   Chakravarthy, Ankur Ravinarayana
RA   Gratrix, Fiona
RA   Patel, Nirali
RA   Vaz, Francis
RA   O'Flynn, Paul
RA   Kalavrezos, Nicholas
RA   Teschendorff, Andrew Erich
RA   Boshoff, Chris
RA   Beck, Stephan
RT   "Identification and functional validation of HPV-mediated
RT   hypermethylation in head and neck squamous cell carcinoma.";
RL   Genome Med. 5:15.1-15.16(2013).
//
RX   PubMed=24201445; DOI=10.1101/gr.164806.113; PMCID=PMC3912410;
RA   Akagi, Keiko
RA   Li, Jing-Feng
RA   Broutian, Tatevik R.
RA   Padilla-Nash, Hesed Maria
RA   Xiao, Wei-Hong
RA   Jiang, Bo
RA   Rocco, James W.
RA   Teknos, Theodoros Null
RA   Kumar, Bhavna
RA   Wangsa, Danny
RA   He, Dan
RA   Ried, Thomas
RA   Symer, David E.
RA   Gillison, Maura Lianne
RT   "Genome-wide analysis of HPV integration in human cancers reveals
RT   recurrent, focal genomic instability.";
RL   Genome Res. 24:185-199(2014).
//
RX   PubMed=28236344; DOI=10.1002/hed.24729; PMCID=PMC5392184;
RA   Walline, Heather M.
RA   Goudsmit, Christine Marie
RA   McHugh, Jonathan B.
RA   Tang, Alice L.
RA   Owen, John Henry
RA   Teh, Bin Tean
RA   McKean, Erin L.
RA   Glover, Thomas W.
RA   Graham, Martin P.
RA   Prince, Mark Edward P.
RA   Chepeha, Douglas Brian
RA   Chinn, Steven B.
RA   Ferris, Robert Louis
RA   Gollin, Susanne M.
RA   Hoffmann, Thomas K.
RA   Bier, Henning
RA   Brakenhoff, Ruud H.
RA   Bradford, Carol R.
RA   Carey, Thomas E.
RG   University of Michigan Head and Neck Specialized Program of Research Excellence (SPORE) Program;
RT   "Integration of high-risk human papillomavirus into cellular
RT   cancer-related genes in head and neck cancer cell lines.";
RL   Head Neck 39:840-852(2017).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//