ID   Sc-1
AC   CVCL_1888
AS   CVCL_2717
SY   SC-1; SC1; Scott; Sci-1; SCI-1; SCI1
DR   CLO; CLO_0037058
DR   EFO; EFO_0006481
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03472729
DR   BioSample; SAMN03473537
DR   cancercelllines; CVCL_1888
DR   Cell_Model_Passport; SIDM00400
DR   ChEMBL-Cells; CHEMBL4523526
DR   ChEMBL-Targets; CHEMBL4523557
DR   Cosmic; 1086345
DR   Cosmic; 1945190
DR   Cosmic; 2297012
DR   Cosmic-CLP; 1331030
DR   DepMap; ACH-002303
DR   DepMap; ACH-002392
DR   DSMZ; ACC-558
DR   DSMZCellDive; ACC-558
DR   ECACC; 96090513
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   EGA; EGAS00001002554
DR   GDSC; 1331031
DR   GEO; GSM119486
DR   GEO; GSM179648
DR   GEO; GSM274843
DR   GEO; GSM827440
DR   GEO; GSM907520
DR   GEO; GSM1035324
DR   GEO; GSM1374861
DR   GEO; GSM1670415
DR   LINCS_LDP; LCL-1951
DR   PharmacoDB; SC1_1350_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1888
DR   Progenetix; CVCL_2717
DR   PubChem_Cell_line; CVCL_1888
DR   Wikidata; Q54952223
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=2985879;
RX   PubMed=3098690;
RX   PubMed=3159941;
RX   PubMed=3874327;
RX   PubMed=8558920;
RX   PubMed=16960149;
RX   PubMed=17495976;
RX   PubMed=20215515;
RX   PubMed=23292937;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=26727417;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=30894373;
RX   PubMed=35839778;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Caucasian.
CC   Doubling time: ~30 hours (DSMZ=ACC-558).
CC   HLA typing: A*02:01,02:01; B*44:02,44:02; C*05:01,05:01; DQA1*01:02,01:02; DQB1*06:02,06:02; DRB1*13:07,15:01 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.02%; Native American=0%; East Asian, North=1.9%; East Asian, South=0%; South Asian=0%; European, North=67.26%; European, South=29.81% (PubMed=30894373).
CC   Discontinued: DepMap; ACH-002303; true.
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
ST   Source(s): Cosmic-CLP=1331030; DSMZ=ACC-558; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 12,13
ST   D13S317: 11,12
ST   D16S539: 9,11
ST   D18S51: 17
ST   D19S433: 15,16
ST   D21S11: 28,29
ST   D2S1338: 18,20
ST   D3S1358: 15,16
ST   D5S818: 11,12
ST   D7S820: 10
ST   D8S1179: 10,14
ST   FGA: 18,24
ST   Penta D: 9,13
ST   Penta E: 12
ST   TH01: 8,9.3 (DSMZ=ACC-558)
ST   TH01: 9.3 (Cosmic-CLP=1331030; PubMed=25877200)
ST   TPOX: 8
ST   vWA: 16,18
DI   NCIt; C3209; Follicular lymphoma
DI   ORDO; Orphanet_545; Follicular lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   67Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 35
//
RX   PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1.
RT   Carboxylic esterase.";
RL   Leuk. Res. 9:209-229(1985).
//
RX   PubMed=23292937; DOI=10.1073/pnas.1205299110; PMCID=PMC3557051;
RA   Zhang, Jenny
RA   Grubor, Vladimir
RA   Love, Cassandra L.
RA   Banerjee, Anjishnu
RA   Richards, Kristy L.
RA   Mieczkowski, Piotr Andrzej
RA   Dunphy, Cherie
RA   Choi, William Wai-Lap
RA   Au, Wing Yan
RA   Srivastava, Gopesh
RA   Lugar, Patricia Lynne
RA   Rizzieri, David A.
RA   Lagoo, Anand S.
RA   Bernal-Mizrachi, Leon
RA   Mann, Karen P.
RA   Flowers, Christopher Robert
RA   Naresh, Kikkeri N.
RA   Evens, Andrew M.
RA   Gordon, Leo I.
RA   Czader, Magdalena Beata
RA   Gill, Javed Iqbal
RA   Hsi, Eric Darryl
RA   Liu, Qing-Quan
RA   Fan, Alice
RA   Walsh, Katherine
RA   Jima, Dereje
RA   Smith, Lisa L.
RA   Johnson, Amy J.
RA   Byrd, John C.
RA   Luftig, Micah Alan
RA   Ni, Ting
RA   Zhu, Jun
RA   Chadburn, Amy
RA   Levy, Shawn
RA   Dunson, David Brian
RA   Dave, Sandeep S.
RT   "Genetic heterogeneity of diffuse large B-cell lymphoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013).
//
RX   PubMed=8558920;
RA   Dirks, Wilhelm Gerhard
RA   Zaborski, Margarete
RA   Jager, Kathrin
RA   Challier, Cecile
RA   Shiota, Mami
RA   Quentmeier, Hilmar
RA   Drexler, Hans Gunther
RT   "The (2;5)(p23;q35) translocation in cell lines derived from malignant
RT   lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.";
RL   Leukemia 10:142-149(1996).
//
RX   PubMed=3098690; DOI=10.1002/ijc.2910390116;
RA   Th'ng, Kang Hock
RA   Garewal, Gurjivan
RA   Kearney, Lyndal
RA   Rassool, Feyruz V.
RA   Vaz de Melo, Junia
RA   White, H.
RA   Catovsky, Daniel
RA   Foroni, Letizia
RA   Luzzatto, Lucio
RA   Goldman, John Michael
RT   "Establishment and characterization of three new malignant lymphoid
RT   cell lines.";
RL   Int. J. Cancer 39:89-93(1987).
//
RX   PubMed=16960149; DOI=10.1182/blood-2006-06-026500;
RA   Mestre-Escorihuela, Cinta
RA   Rubio-Moscardo, Fanny
RA   Richter, Jose A.
RA   Siebert, Reiner
RA   Climent, Joan
RA   Fresquet, Vicente
RA   Beltran, Elena
RA   Agirre, Xabier
RA   Marugan, Isabel
RA   Marin, Miguel
RA   Rosenwald, Andreas
RA   Sugimoto, Kei-ji
RA   Wheat, Luise M.
RA   Karran, E. Loraine
RA   Garcia Garcia, Juan Fernando
RA   Sanchez-Verde, Lydia
RA   Prosper, Felipe
RA   Staudt, Louis Michael
RA   Pinkel, Daniel
RA   Dyer, Martin John Swinnerton
RA   Martinez-Climent, Jose Angel
RT   "Homozygous deletions localize novel tumor suppressor genes in B-cell
RT   lymphomas.";
RL   Blood 109:271-280(2007).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- III.
RT   Beta-hexosaminidase (E.C. 3.2.1.30).";
RL   Leuk. Res. 9:549-559(1985).
//
RX   PubMed=17495976; DOI=10.1038/sj.leu.2404696;
RA   Fitzgibbon, Jude
RA   Iqbal, Sameena
RA   Davies, Andrews J.
RA   O'Shea, Derville
RA   Carlotti, Emanuela
RA   Chaplin, Tracy
RA   Matthews, Janet
RA   Raghavan, Manoj
RA   Norton, Andrew J.
RA   Lister, Thomas Andrew
RA   Young, Bryan Douglas
RT   "Genome-wide detection of recurring sites of uniparental disomy in
RT   follicular and transformed follicular lymphoma.";
RL   Leukemia 21:1514-1520(2007).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid
RT   phosphatase.";
RL   Leuk. Res. 9:537-548(1985).
//
RX   PubMed=26727417; DOI=10.3109/10428194.2015.1108414;
RA   Drexler, Hans Gunther
RA   Eberth, Sonja
RA   Nagel, Stefan
RA   MacLeod, Roderick A.F.
RT   "Malignant hematopoietic cell lines: in vitro models for double-hit
RT   B-cell lymphomas.";
RL   Leuk. Lymphoma 57:1015-1020(2016).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//