ID   OCI-Ly18
AC   CVCL_1880
AS   CVCL_9551
SY   OCI-LY18; OCI-LY-18; OCILY18; OCI-Ly 18; Ly18; LY18
DR   BioSample; SAMN03473448
DR   cancercelllines; CVCL_1880
DR   ChEMBL-Cells; CHEMBL4523522
DR   ChEMBL-Targets; CHEMBL4523553
DR   Cosmic; 1295513
DR   Cosmic; 1517651
DR   Cosmic; 1541906
DR   Cosmic; 1636683
DR   Cosmic; 2276334
DR   DepMap; ACH-001616
DR   DSMZ; ACC-699
DR   DSMZCellDive; ACC-699
DR   GEO; GSM380131
DR   GEO; GSM552456
DR   GEO; GSM1374785
DR   Progenetix; CVCL_1880
DR   PubChem_Cell_line; CVCL_1880
DR   Wikidata; Q54931770
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1311715;
RX   PubMed=8574164;
RX   PubMed=11807979;
RX   PubMed=19278952;
RX   PubMed=20628145;
RX   PubMed=26727417;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   From: Ontario Cancer Institute (OCI); Toronto; Canada.
CC   Doubling time: ~30-40 hours (DSMZ=ACC-699).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (DepMap=ACH-001616).
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Misspelling: OCI-LZ18; BioSample=SAMN03473448.
CC   Misspelling: SU-DHL-18; Cosmic=1295513.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): DepMap=ACH-001616; DSMZ=ACC-699
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 10,12
ST   D16S539: 11,13
ST   D18S51: 15,19
ST   D19S433: 13,14
ST   D21S11: 31
ST   D2S1338: 18,24
ST   D3S1358: 14,15
ST   D5S818: 11,12
ST   D7S820: 10,12
ST   D8S1179: 10,13
ST   FGA: 19,21
ST   Penta D: 10
ST   Penta E: 5,14
ST   TH01: 6,9
ST   TPOX: 8,11
ST   vWA: 15,19
DI   NCIt; C8851; Diffuse large B-cell lymphoma
DI   ORDO; Orphanet_544; Diffuse large B-cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   56Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 30
//
RX   PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356;
RA   Green, Michael Richard
RA   Monti, Stefano
RA   Rodig, Scott J.
RA   Juszczynski, Przemyslaw
RA   Currie, Treeve
RA   O'Donnell, Evan
RA   Chapuy, Bjoern
RA   Takeyama, Kunihiko
RA   Neuberg, Donna
RA   Golub, Todd Robert
RA   Kutok, Jeffery L.
RA   Shipp, Margaret Ann
RT   "Integrative analysis reveals selective 9p24.1 amplification,
RT   increased PD-1 ligand expression, and further induction via JAK2 in
RT   nodular sclerosing Hodgkin lymphoma and primary mediastinal large
RT   B-cell lymphoma.";
RL   Blood 116:3268-3277(2010).
//
RX   PubMed=8574164; DOI=10.3109/10428199509059672;
RA   Chang, Hong
RA   Blondal, John A.
RA   Benchimol, Sam
RA   Minden, Mark David
RA   Messner, Hans August
RT   "p53 mutations, c-myc and bcl-2 rearrangements in human non-Hodgkin's
RT   lymphoma cell lines.";
RL   Leuk. Lymphoma 19:165-171(1995).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=1311715; DOI=10.1172/JCI115642; PMCID=PMC442951;
RA   Chang, Hong
RA   Messner, Hans August
RA   Wang, Xin-Hua
RA   Yee, Cassian
RA   Addy, Lynda
RA   Meharchand, Jacinta
RA   Minden, Mark David
RT   "A human lymphoma cell line with multiple immunoglobulin
RT   rearrangements.";
RL   J. Clin. Invest. 89:1014-1020(1992).
//
RX   PubMed=19278952; DOI=10.1182/blood-2009-01-202028; PMCID=PMC3401058;
RA   Li, Cheng
RA   Kim, Sang-Woo
RA   Rai, Deepak
RA   Bolla, Aswani R.
RA   Adhvaryu, Siddharth
RA   Kinney, Marsha C.
RA   Robetorye, Ryan S.
RA   Aguiar, Ricardo C.T.
RT   "Copy number abnormalities, MYC activity, and the genetic fingerprint
RT   of normal B cells mechanistically define the microRNA profile of
RT   diffuse large B-cell lymphoma.";
RL   Blood 113:6681-6690(2009).
//
RX   PubMed=26727417; DOI=10.3109/10428194.2015.1108414;
RA   Drexler, Hans Gunther
RA   Eberth, Sonja
RA   Nagel, Stefan
RA   MacLeod, Roderick A.F.
RT   "Malignant hematopoietic cell lines: in vitro models for double-hit
RT   B-cell lymphomas.";
RL   Leuk. Lymphoma 57:1015-1020(2016).
//
RX   PubMed=11807979; DOI=10.1002/gcc.10025;
RA   Mehra, Sukvarsha
RA   Messner, Hans August
RA   Minden, Mark David
RA   Chaganti, Raju S.K.
RT   "Molecular cytogenetic characterization of non-Hodgkin lymphoma cell
RT   lines.";
RL   Genes Chromosomes Cancer 33:225-234(2002).
//