ID   MEC-1
AC   CVCL_1870
SY   MEC1
DR   BTO; BTO_0005913
DR   CLO; CLO_0037181
DR   EFO; EFO_0002231
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   BioSample; SAMN03471015
DR   BioSample; SAMN10989555
DR   cancercelllines; CVCL_1870
DR   Cell_Model_Passport; SIDM00001
DR   ChEMBL-Cells; CHEMBL4482990
DR   ChEMBL-Targets; CHEMBL4483257
DR   Cosmic; 1762462
DR   DepMap; ACH-000405
DR   DSMZ; ACC-497
DR   DSMZCellDive; ACC-497
DR   EGA; EGAS00001000978
DR   GDSC; 1330943
DR   GEO; GSM887305
DR   GEO; GSM888381
DR   GEO; GSM1374667
DR   GEO; GSM1670091
DR   IARC_TP53; 28260
DR   IGRhCellID; MEC1
DR   LiGeA; CCLE_715
DR   LINCS_LDP; LCL-1089
DR   PharmacoDB; MEC1_911_2019
DR   Progenetix; CVCL_1870
DR   PubChem_Cell_line; CVCL_1870
DR   Wikidata; Q54904995
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=10071128;
RX   PubMed=20215515;
RX   PubMed=20454443;
RX   PubMed=22460905;
RX   PubMed=23297799;
RX   PubMed=25162594;
RX   PubMed=25877200;
RX   PubMed=28196595;
RX   PubMed=30285677;
RX   PubMed=30629668;
RX   PubMed=30894373;
RX   PubMed=31068700;
RX   PubMed=31160637;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: LL-100 blood cancer cell line panel.
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Caucasian.
CC   Doubling time: ~40 hours (PubMed=10071128; DSMZ=ACC-497).
CC   HLA typing: A*23:01:01,30:01:01; B*13:02:01;18:01:01; C*06:02:01;12:03:01; DPA1*01:03:01;01:03:01; DPB1*04:02:01;02:01:02; DQA1*01:02:01;05:05:01; DQB1*03:01:01;06:02:01; DRA*01:02:02;01:02:03; DRB1*12:01:01;15:01:01 (DSMZCellDive=ACC-497).
CC   Sequence variation: Gene fusion; HGNC; HGNC:9476; HTRA1 + HGNC; HGNC:23512; R3HCC1L; Name(s)=R3HCC1L-HTRA1 (PubMed=31160637).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln317Profs*20 (c.949dupC) (c.949_950insC); Zygosity=Homozygous (DepMap=ACH-000405).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.9%; Native American=0%; East Asian, North=2.04%; East Asian, South=0%; South Asian=5.76%; European, North=26.14%; European, South=64.15% (PubMed=30894373).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): DSMZ=ACC-497; PubMed=25877200; Technion Genomics Center
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D10S1248: 17
ST   D12S391: 24
ST   D13S317: 11,12
ST   D16S539: 9,11
ST   D18S51: 14
ST   D19S433: 12,14
ST   D1S1656: 15,17
ST   D21S11: 27,29
ST   D22S1045: 15,16
ST   D2S1338: 16,19
ST   D2S441: 14
ST   D3S1358: 15,19
ST   D5S818: 10,12
ST   D7S820: 7,11
ST   D8S1179: 13,15
ST   DYS391: 10
ST   FGA: 21,25
ST   Penta D: 11,17
ST   Penta E: 10,12
ST   TH01: 6,8
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C3163; Chronic lymphocytic leukemia
DI   ORDO; Orphanet_67038; B-cell chronic lymphocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1871 ! MEC-2
SX   Male
AG   61Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 38
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=20454443; DOI=10.1155/2010/904767; PMCID=PMC2861168;
RA   Uphoff, Cord C.
RA   Denkmann, Sabine A.
RA   Steube, Klaus G.
RA   Drexler, Hans Gunther
RT   "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human
RT   and other primate cell lines.";
RL   J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).
//
RX   PubMed=10071128; DOI=10.1016/S0145-2126(98)00154-4;
RA   Stacchini, Alessandra
RA   Aragno, Michela
RA   Vallario, Antonella
RA   Alfarano, Alda
RA   Circosta, Paola
RA   Gottardi, Daniela
RA   Faldella, Alessandra
RA   Rege-Cambrin, Giovanna
RA   Thunberg, Ulf
RA   Nilsson, Kenneth
RA   Caligaris-Cappio, Federico
RT   "MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic
RT   leukaemia in prolymphocytoid transformation.";
RL   Leuk. Res. 23:127-136(1999).
//
RX   PubMed=25162594; DOI=10.1371/journal.pone.0106008; PMCID=PMC4146575;
RA   Rasul, Eahsan
RA   Salamon, Daniel
RA   Nagy, Noemi
RA   Leveau, Benjamin
RA   Banati, Ferenc
RA   Szenthe, Kalman
RA   Koroknai, Anita
RA   Minarovits, Janos
RA   Klein, George
RA   Klein, Eva
RT   "The MEC1 and MEC2 lines represent two CLL subclones in different
RT   stages of progression towards prolymphocytic leukemia.";
RL   PLoS ONE 9:e106008.1-e106008.8(2014).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027;
RA   Barretina, Jordi Ginesta
RA   Caponigro, Giordano
RA   Stransky, Nicolas
RA   Venkatesan, Kavitha
RA   Margolin, Adam A.
RA   Kim, Sungjoon
RA   Wilson, Christopher J.
RA   Lehar, Joseph
RA   Kryukov, Gregory V.
RA   Sonkin, Dmitriy
RA   Reddy, Anupama
RA   Liu, Manway
RA   Murray, Lauren
RA   Berger, Michael F.
RA   Monahan, John E.
RA   Morais, Paula
RA   Meltzer, Jodi
RA   Korejwa, Adam
RA   Jane-Valbuena, Judit
RA   Mapa, Felipa A.
RA   Thibault, Joseph
RA   Bric-Furlong, Eva
RA   Raman, Pichai
RA   Shipway, Aaron
RA   Engels, Ingo H.
RA   Cheng, Jill
RA   Yu, Guo-Ying K.
RA   Yu, Jian-Jun
RA   Aspesi, Peter Jr.
RA   de Silva, Melanie
RA   Jagtap, Kalpana
RA   Jones, Michael D.
RA   Wang, Li
RA   Hatton, Charles
RA   Palescandolo, Emanuele
RA   Gupta, Supriya
RA   Mahan, Scott
RA   Sougnez, Carrie
RA   Onofrio, Robert C.
RA   Liefeld, Ted
RA   MacConaill, Laura Eleanor
RA   Winckler, Wendy
RA   Reich, Michael
RA   Li, Nan-Xin
RA   Mesirov, Jill P.
RA   Gabriel, Stacey B.
RA   Getz, Gad
RA   Ardlie, Kristin
RA   Chan, Vivien
RA   Myer, Vic E.
RA   Weber, Barbara L.
RA   Porter, Jeff
RA   Warmuth, Markus
RA   Finan, Peter
RA   Harris, Jennifer L.
RA   Meyerson, Matthew Langer
RA   Golub, Todd Robert
RA   Morrissey, Michael P.
RA   Sellers, William Raj
RA   Schlegel, Robert
RA   Garraway, Levi Alexander
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144;
RA   Uphoff, Cord C.
RA   Pommerenke, Claudia
RA   Denkmann, Sabine A.
RA   Drexler, Hans Gunther
RT   "Screening human cell lines for viral infections applying RNA-Seq data
RT   analysis.";
RL   PLoS ONE 14:e0210404.1-e0210404.22(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646;
RA   Quentmeier, Hilmar
RA   Pommerenke, Claudia
RA   Dirks, Wilhelm Gerhard
RA   Eberth, Sonja
RA   Koeppel, Max
RA   MacLeod, Roderick A.F.
RA   Nagel, Stefan
RA   Steube, Klaus G.
RA   Uphoff, Cord C.
RA   Drexler, Hans Gunther
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218.1-8218.14(2019).
//
RX   PubMed=23297799; DOI=10.3109/10428194.2013.764418;
RA   Myhrinder, Anna Lanemo
RA   Hellqvist, Eva
RA   Bergh, Ann-Charlotte
RA   Jansson, Mattias
RA   Nilsson, Kenneth
RA   Hultman, Per
RA   Jonasson, Jon
RA   Buhl, Anne Mette
RA   Pedersen, Lone Bredo
RA   Jurlander, Jesper
RA   Klein, Eva
RA   Weit, Nicole
RA   Herling, Marco
RA   Rosenquist, Richard
RA   Rosen, Anders
RT   "Molecular characterization of neoplastic and normal 'sister'
RT   lymphoblastoid B-cell lines from chronic lymphocytic leukemia.";
RL   Leuk. Lymphoma 54:1769-1779(2013).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786;
RA   Tan, Kar-Tong
RA   Ding, Ling-Wen
RA   Sun, Qiao-Yang
RA   Lao, Zhen-Tang
RA   Chien, Wenwen
RA   Ren, Xi
RA   Xiao, Jin-Fen
RA   Loh, Xin-Yi
RA   Xu, Liang
RA   Lill, Michael
RA   Mayakonda, Anand
RA   Lin, De-Chen
RA   Yang, Henry He
RA   Koeffler, Harold Phillip
RT   "Profiling the B/T cell receptor repertoire of lymphocyte derived cell
RT   lines.";
RL   BMC Cancer 18:940.1-940.13(2018).
//