ID PaTu 8988s AC CVCL_1846 SY PA-TU-8988S; PaTu8988s; PaTu8988S; PATU8988S; PaTu 8988 S; PaTu-8988s; PATU-8988S; PATU-S; PA-TU S DR BTO; BTO_0005879 DR CLO; CLO_0008383 DR EFO; EFO_0006730 DR CLDB; cl3861 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR BioGRID_ORCS_Cell_line; 258 DR BioSample; SAMN10987622 DR cancercelllines; CVCL_1846 DR Cell_Model_Passport; SIDM00452 DR Cosmic; 873007 DR Cosmic; 2046530 DR Cosmic; 2434103 DR DepMap; ACH-000022 DR DSMZ; ACC-204 DR DSMZCellDive; ACC-204 DR EGA; EGAS00001000610 DR GEO; GSM887503 DR GEO; GSM888585 DR IARC_TP53; 2967 DR IARC_TP53; 30144 DR LiGeA; CCLE_100 DR LINCS_LDP; LCL-1745 DR PharmacoDB; PATU8988S_1237_2019 DR Progenetix; CVCL_1846 DR Wikidata; Q54938329 RX DOI=10.4172/2324-9293.1000104; RX PubMed=1348891; RX PubMed=8194712; RX PubMed=11416159; RX PubMed=11668190; RX PubMed=15126341; RX PubMed=15688027; RX PubMed=22460905; RX PubMed=22585861; RX PubMed=25167228; RX PubMed=25485619; RX PubMed=26216984; RX PubMed=26589293; RX PubMed=28196595; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31395879; WW Info; MCLP; -; https://tcpaportal.org/mclp/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: MD Anderson Cell Lines Project. CC Part of: TCGA-110-CL cell line panel. CC Population: Caucasian. CC Doubling time: 2-2.6 days (PubMed=1348891); ~40-60 hours (DSMZ=ACC-204). CC HLA typing: A*31:01,32:01; B*27:05,35:01; C*02:02,04:01 (PubMed=26589293). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (DepMap=ACH-000022). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Homozygous (DepMap=ACH-000022). CC Omics: Genomics; Whole exome sequencing. CC Omics: Metabolomics. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=1.16%; Native American=0%; East Asian, North=1.35%; East Asian, South=0%; South Asian=0%; European, North=59.03%; European, South=38.45% (PubMed=30894373). CC Caution: TP53 mutation indicated incorrectly as being at p.Cys176Ser (c.451C>T) in PubMed=8194712. CC Derived from site: Metastatic; Liver; UBERON=UBERON_0002107. ST Source(s): DSMZ=ACC-204; PubMed=11416159 ST Amelogenin: X ST CSF1PO: 11,13 ST D13S317: 12,13 ST D16S539: 11,12 ST D18S51: 12 ST D19S433: 14,15 ST D21S11: 26 ST D2S1338: 23 ST D3S1358: 15,17 ST D5S818: 11,13 ST D7S820: 7,8 ST D8S1179: 13,16 ST FGA: 23 ST Penta D: 8 ST Penta E: 13 ST TH01: 6 ST TPOX: 8,11 ST vWA: 16 DI NCIt; C8294; Pancreatic adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) OI CVCL_1847 ! PaTu 8988t SX Female AG 64Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 38 // RX PubMed=15126341; DOI=10.1158/0008-5472.CAN-03-3159; RA Heidenblad, Markus RA Schoenmakers, Eric F.P.M. RA Jonson, Tord RA Gorunova, Ludmila RA Veltman, Joris Andre RA van Kessel, Ad Geurts RA Hoglund, Mattias RT "Genome-wide array-based comparative genomic hybridization reveals RT multiple amplification targets and novel homozygous deletions in RT pancreatic carcinoma cell lines."; RL Cancer Res. 64:3052-3059(2004). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396; RA Marcotte, Richard RA Brown, Kevin R. RA Suarez Saiz, Fernando Jose RA Sayad, Azin RA Karamboulas, Konstantina RA Krzyzanowski, Paul M. RA Sircoulomb, Fabrice RA Medrano, Mauricio RA Fedyshyn, Yaroslav RA Koh, Judice Lie-Yong RA van Dyk, Dewald RA Fedyshyn, Bohdana RA Luhova, Marianna RA Brito, Glauber C. RA Vizeacoumar, Franco J. RA Vizeacoumar, Frederick S. RA Datti, Alessandro RA Kasimer, Dahlia RA Buzina, Alla RA Mero, Patricia RA Misquitta, Christine RA Normand, Josee RA Haider, Maliha RA Ketela, Troy RA Wrana, Jeffrey L. RA Rottapel, Robert RA Neel, Benjamin G. RA Moffat, Jason RT "Essential gene profiles in breast, pancreatic, and ovarian cancer RT cells."; RL Cancer Discov. 2:172-189(2012). // RX PubMed=11668190; DOI=10.1177/002215540104901105; RA Quentmeier, Hilmar RA Osborn, Mary RA Reinhardt, Julia RA Zaborski, Margarete RA Drexler, Hans Gunther RT "Immunocytochemical analysis of cell lines derived from solid RT tumors."; RL J. Histochem. Cytochem. 49:1369-1378(2001). // RX PubMed=8194712; DOI=10.1016/0016-5085(94)90422-7; RA Simon, Babette RA Weinel, Rolf RA Hohne, Martin RA Watz, Jutta RA Schmidt, Jorg RA Kortner, Gunther RA Arnold, Rudolf RT "Frequent alterations of the tumor suppressor genes p53 and DCC in RT human pancreatic carcinoma."; RL Gastroenterology 106:1645-1651(1994). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785; RA Yu, Katharine RA Chen, Bin RA Aran, Dvir RA Charalel, Joe RA Yau, Christina RA Wolf, Douglas M. RA van 't Veer, Laura J. RA Butte, Atul Janardhan RA Goldstein, Ted RA Sirota, Marina RT "Comprehensive transcriptomic analysis of cell lines as models of RT primary tumors across 22 tumor types."; RL Nat. Commun. 10:3574.1-3574.11(2019). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=25167228; DOI=10.1038/bjc.2014.475; PMCID=PMC4453732; RA Hamidi, Habib RA Lu, Ming RA Chau, Kevin RA Anderson, Lee RA Fejzo, Marlena Schoenberg RA Ginther, Charles RA Linnartz, Ronald RA Zubel, Angela RA Slamon, Dennis Joseph RA Finn, Richard Samuel RT "KRAS mutational subtype and copy number predict in vitro response of RT human pancreatic cancer cell lines to MEK inhibition."; RL Br. J. Cancer 111:1788-1801(2014). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=1348891; DOI=10.1007/BF02890431; RA Elsasser, Hans-Peter RA Lehr, Uschi RA Agricola, Brigitte RA Kern, Horst Franz RT "Establishment and characterisation of two cell lines with different RT grade of differentiation derived from one primary human pancreatic RT adenocarcinoma."; RL Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathol. 61:295-306(1992). // RX PubMed=15688027; DOI=10.1038/sj.onc.1208383; RA Heidenblad, Markus RA Lindgren, David RA Veltman, Joris Andre RA Jonson, Tord RA Mahlamaki, Eija H. RA Gorunova, Ludmila RA van Kessel, Ad Geurts RA Schoenmakers, Eric F.P.M. RA Hoglund, Mattias RT "Microarray analyses reveal strong influence of DNA copy number RT alterations on the transcriptional patterns in pancreatic cancer: RT implications for the interpretation of genomic amplifications."; RL Oncogene 24:1794-1801(2005). // RX PubMed=26216984; DOI=10.1073/pnas.1501605112; PMCID=PMC4538616; RA Daemen, Anneleen RA Peterson, David RA Sahu, Nisebita RA McCord, Ron RA Du, Xiang-Nan RA Liu, Bonnie RA Kowanetz, Katarzyna RA Hong, Rebecca RA Moffat, John RA Gao, Min RA Boudreau, Aaron RA Mroue, Rana RA Corson, Laura RA O'Brien, Thomas RA Qing, Jing RA Sampath, Deepak RA Merchant, Mark RA Yauch, Robert L. RA Manning, Gerard RA Settleman, Jeffrey RA Hatzivassiliou, Georgia RA Evangelista, Marie RT "Metabolite profiling stratifies pancreatic ductal adenocarcinomas RT into subtypes with distinct sensitivities to metabolic inhibitors."; RL Proc. Natl. Acad. Sci. U.S.A. 112:E4410-E4417(2015). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX DOI=10.4172/2324-9293.1000104; RA Wagenhauser, Markus Udo RA Ruckert, Felix RA Niedergethmann, Marco RA Grutzmann, Robert RA Saeger, Hans-Detlev RT "Distribution of characteristic mutations in native ductal RT adenocarcinoma of the pancreas and pancreatic cancer cell lines."; RL Cell Biol. Res. Ther. 2:1000104.1-1000104.5(2013). // RX PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459; RA Masters, John R.W. RA Thomson, Jim A. RA Daly-Burns, Bernadette RA Reid, Yvonne A. RA Dirks, Wilhelm Gerhard RA Packer, Phil RA Toji, Lorraine Hellenga RA Ohno, Tadao RA Tanabe, Hideyuki RA Arlett, Colin Francis RA Kelland, Lloyd R. RA Harrison, Maureen RA Virmani, Arvind K. RA Ward, Timothy H. RA Ayres, Karen L. RA Debenham, Paul G. RT "Short tandem repeat profiling provides an international reference RT standard for human cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001). //