ID OCI-AML-3 AC CVCL_1844 SY OCI-Aml-3; OCI/AML-3; OCI-AML3; OCI/AML3; OCI AML3; OCIAML3; Ontario Cancer Institute-Acute Myeloid Leukemia-3 DR BTO; BTO_0004620 DR CLO; CLO_0009853 DR EFO; EFO_0006289 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ArrayExpress; E-MTAB-7721 DR ArrayExpress; E-MTAB-7722 DR BioGRID_ORCS_Cell_line; 214 DR BioSample; SAMN03473107 DR BioSample; SAMN10988470 DR cancercelllines; CVCL_1844 DR CCTCC; GDC0216 DR Cell_Model_Passport; SIDM00462 DR ChEMBL-Cells; CHEMBL4295392 DR ChEMBL-Targets; CHEMBL4296479 DR Cosmic; 787467 DR Cosmic; 975289 DR Cosmic; 1012110 DR Cosmic; 1127258 DR Cosmic; 1245831 DR Cosmic; 1319546 DR Cosmic; 1557602 DR Cosmic; 1582387 DR Cosmic; 1696140 DR Cosmic; 1779129 DR Cosmic; 2131552 DR Cosmic; 2306232 DR Cosmic; 2750869 DR Cosmic-CLP; 1290455 DR DepMap; ACH-000336 DR DSMZ; ACC-582 DR DSMZCellDive; ACC-582 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 1290455 DR GEO; GSM482512 DR GEO; GSM887469 DR GEO; GSM888549 DR GEO; GSM1446756 DR GEO; GSM1525022 DR GEO; GSM1670296 DR GEO; GSM2716711 DR GEO; GSM2716712 DR GEO; GSM2716774 DR GEO; GSM2716775 DR GEO; GSM2716776 DR GEO; GSM2716777 DR IARC_TP53; 30132 DR LiGeA; CCLE_569 DR LINCS_LDP; LCL-1066 DR Lonza; 530 DR PharmacoDB; OCIAML3_1184_2019 DR Progenetix; CVCL_1844 DR PubChem_Cell_line; CVCL_1844 DR Ubigene; YC-C022 DR Wikidata; Q54931742 RX PubMed=2538684; RX PubMed=12393637; RX PubMed=16079892; RX PubMed=16408098; RX PubMed=21552520; RX PubMed=22460905; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25984343; RX PubMed=26434589; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28109323; RX PubMed=29491412; RX PubMed=30285677; RX PubMed=30629668; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=31160637; RX PubMed=31739141; RX PubMed=36982453; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: LL-100 blood cancer cell line panel. CC Population: Caucasian. CC Doubling time: 28 hours (PubMed=25984343); ~35-40 hours (DSMZ=ACC-582). CC HLA typing: A*02:01,23:01; B*44:02,53:01; C*04:01,05:01 (PubMed=26589293). CC HLA typing: A*02:01:01,23:01:01; B*44:02:01,53:01:01; C*04:01:01,05:01:01 (DSMZCellDive=ACC-582). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:2978; DNMT3A; Simple; p.Arg882Cys (c.2644C>T); ClinVar=VCV000375882; Zygosity=Heterozygous (PubMed=26434589; PubMed=31160637; PubMed=31739141; Cosmic-CLP=1290455; DepMap=ACH-000336). CC Sequence variation: Mutation; HGNC; HGNC:7910; NPM1; Simple; p.Trp288Cysfs*12 (c.860_863dupTCTG); ClinVar=VCV000013998; Zygosity=Heterozygous (PubMed=16079892). CC Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Homozygous (Cosmic-CLP=1290455; DepMap=ACH-000336). CC Omics: Genomics; ChIP-seq; H3K27ac. CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Phenotyping; shRNA library screening. CC Omics: Proteomics; PTM; Phosphorylation; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=1.44%; East Asian, North=2.86%; East Asian, South=0%; South Asian=0.99%; European, North=55.94%; European, South=38.78% (PubMed=30894373). CC Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. ST Source(s): Cosmic-CLP=1290455; DSMZ=ACC-582; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 11,12 ST D13S317: 8,13 ST D16S539: 11,13 ST D18S51: 12,18 ST D19S433: 15,17 ST D21S11: 29,30 ST D2S1338: 17,21 ST D3S1358: 16 ST D5S818: 11,13 ST D7S820: 9,10 ST D8S1179: 10,12 ST FGA: 22 ST Penta D: 12,13 ST Penta E: 11,13 ST TH01: 8,9.3 (DSMZ=ACC-582) ST TH01: 8,10 (Cosmic-CLP=1290455; PubMed=25877200) ST TPOX: 8,11 ST vWA: 17,18 DI NCIt; C7962; Adult acute myelomonocytic leukemia DI ORDO; Orphanet_517; Acute myelomonocytic leukemia OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 57Y CA Cancer cell line DT Created: 04-04-12; Last updated: 14-08-25; Version: 46 CH CVCL_D6C9 ! HyCyte OCI-AML3 KO-hFGL2 CH CVCL_D6NG ! OCI-AML3/HaABCG2 clone 3.3 CH CVCL_5227 ! OCI-AML3/HaABCG2 clone 6.2 CH CVCL_D6NF ! OCI-AML3DNR // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786; RA Tan, Kar-Tong RA Ding, Ling-Wen RA Sun, Qiao-Yang RA Lao, Zhen-Tang RA Chien, Wenwen RA Ren, Xi RA Xiao, Jin-Fen RA Loh, Xin-Yi RA Xu, Liang RA Lill, Michael RA Mayakonda, Anand RA Lin, De-Chen RA Yang, Henry He RA Koeffler, Harold Phillip RT "Profiling the B/T cell receptor repertoire of lymphocyte derived cell RT lines."; RL BMC Cancer 18:940.1-940.13(2018). // RX PubMed=26434589; DOI=10.1038/onc.2015.359; PMCID=PMC4705435; RA Ferreira, Humberto J. RA Heyn, Holger RA Vizoso, Miguel RA Moutinho, Catia RA Vidal, Enrique RA Gomez, Antonio RA Martinez-Cardus, Anna RA Simo-Riudalbas, Laia RA Moran, Sebastian RA Jost, Edgar RA Esteller, Manel RT "DNMT3A mutations mediate the epigenetic reactivation of the RT leukemogenic factor MEIS1 in acute myeloid leukemia."; RL Oncogene 35:3079-3082(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=28109323; DOI=10.1186/s13045-017-0396-0; PMCID=PMC5251306; RA Masetti, Riccardo RA Bertuccio, Salvatore Nicola RA Astolfi, Annalisa RA Chiarini, Francesca RA Lonetti, Annalisa RA Indio, Valentina RA De Luca, Matilde RA Bandini, Jessica RA Serravalle, Salvatore RA Franzoni, Monica RA Pigazzi, Martina RA Martelli, Alberto Maria RA Basso, Giuseppe RA Locatelli, Franco RA Pession, Andrea RT "Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion RT gene."; RL J. Hematol. Oncol. 10:26.1-26.5(2017). // RX PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144; RA Uphoff, Cord C. RA Pommerenke, Claudia RA Denkmann, Sabine A. RA Drexler, Hans Gunther RT "Screening human cell lines for viral infections applying RNA-Seq data RT analysis."; RL PLoS ONE 14:e0210404.1-e0210404.22(2019). // RX PubMed=31739141; DOI=10.1016/j.leukres.2019.106270; RA Quentmeier, Hilmar RA Pommerenke, Claudia RA Dirks, Wilhelm Gerhard RA Fahnrich, Silke RA Hauer, Vivien RA Uphoff, Cord C. RA Zaborski, Margarete RA Drexler, Hans Gunther RT "DNMT3A R882H mutation in acute myeloid leukemia cell line SET-2."; RL Leuk. Res. 88:106270.1-106270.3(2020). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=16408098; DOI=10.1038/sj.leu.2404081; RA Quentmeier, Hilmar RA MacLeod, Roderick A.F. RA Zaborski, Margarete RA Drexler, Hans Gunther RT "JAK2 V617F tyrosine kinase mutation in cell lines derived from RT myeloproliferative disorders."; RL Leukemia 20:471-476(2006). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=36982453; DOI=10.3390/ijms24065377; PMCID=PMC10049680; RA Skopek, Rafal RA Palusinska, Malgorzata RA Kaczor-Keller, Katarzyna RA Pingwara, Rafal RA Papierniak-Wygladala, Anna RA Schenk, Tino RA Lewicki, Slawomir RA Zelent, Artur RA Szymanski, Lukasz RT "Choosing the right cell line for acute myeloid leukemia (AML) RT research."; RL Int. J. Mol. Sci. 24:5377.1-5377.34(2023). // RX PubMed=21552520; DOI=10.1371/journal.pone.0019169; PMCID=PMC3084268; RA Gu, Ting-Lei RA Nardone, Julie RA Wang, Yi RA Loriaux, Marc RA Villen, Judit RA Beausoleil, Sean A. RA Tucker, Meghan RA Kornhauser, Jon M. RA Ren, Jian-Min RA MacNeill, Joan RA Gygi, Steven P. RA Druker, Brian Jay RA Heinrich, Michael Charles RA Rush, John RA Polakiewicz, Roberto D. RT "Survey of activated FLT3 signaling in leukemia."; RL PLoS ONE 6:e19169.1-e19169.10(2011). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=12393637; DOI=10.1182/blood-2002-01-0271; RA Abbott, Brian L. RA Colapietro, Anne-Marie RA Barnes, Yu-Xiao Elizabeth RA Marini, Frank C. RA Andreeff, Michael RA Sorrentino, Brian P. RT "Low levels of ABCG2 expression in adult AML blast samples."; RL Blood 100:4594-4601(2002). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura E. RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=29491412; DOI=10.1038/s41388-018-0150-2; PMCID=PMC5955861; RA Gerlach, Daniel RA Tontsch-Grunt, Ulrike RA Baum, Anke RA Popow, Johannes RA Scharn, Dirk RA Hofmann, Marco H. RA Engelhardt, Harald RA Kaya, Onur RA Beck, Janina RA Schweifer, Norbert RA Gerstberger, Thomas RA Zuber, Johannes RA Savarese, Fabio RA Kraut, Norbert RT "The novel BET bromodomain inhibitor BI 894999 represses RT super-enhancer-associated transcription and synergizes with CDK9 RT inhibition in AML."; RL Oncogene 37:2687-2701(2018). // RX PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652; RA Cowley, Glenn S. RA Weir, Barbara A. RA Vazquez, Francisca RA Tamayo, Pablo RA Scott, Justine A. RA Rusin, Scott RA East-Seletsky, Alexandra RA Ali, Levi D. RA Gerath, William F.J. RA Pantel, Sarah E. RA Lizotte, Patrick Hall RA Jiang, Guo-Zhi RA Hsiao, Jessica RA Tsherniak, Aviad RA Dwinell, Elizabeth RA Aoyama, Simon RA Okamoto, Michael RA Harrington, William RA Gelfand, Ellen T. RA Green, Thomas M. RA Tomko, Mark J. RA Gopal, Shuba RA Wong, Terence C. RA Li, Hu-Bo RA Howell, Sara RA Stransky, Nicolas RA Liefeld, Ted RA Jang, Dongkeun RA Bistline, Jonathan RA Meyers, Barbara Hill RA Armstrong, Scott Allen RA Anderson, Kenneth Carl RA Stegmaier, Kimberly RA Reich, Michael RA Pellman, David RA Boehm, Jesse S. RA Mesirov, Jill P. RA Golub, Todd Robert RA Root, David E. RA Hahn, William Chun RT "Parallel genome-scale loss of function screens in 216 cancer cell RT lines for the identification of context-specific genetic RT dependencies."; RL Sci. Data 1:140035.1-140035.12(2014). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=16079892; DOI=10.1038/sj.leu.2403899; RA Quentmeier, Hilmar RA Martelli, Maria Paola RA Dirks, Wilhelm Gerhard RA Bolli, Niccolo RA Liso, Arcangelo RA MacLeod, Roderick A.F. RA Nicoletti, Ines RA Mannucci, Roberta RA Pucciarini, Alessandra RA Bigerna, Barbara RA Martelli, Massimo Fabrizio RA Mecucci, Cristina RA Drexler, Hans Gunther RA Falini, Brunangelo RT "Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic RT expression of nucleophosmin."; RL Leukemia 19:1760-1767(2005). // RX PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646; RA Quentmeier, Hilmar RA Pommerenke, Claudia RA Dirks, Wilhelm Gerhard RA Eberth, Sonja RA Koeppel, Max RA MacLeod, Roderick A.F. RA Nagel, Stefan RA Steube, Klaus G. RA Uphoff, Cord C. RA Drexler, Hans Gunther RT "The LL-100 panel: 100 cell lines for blood cancer studies."; RL Sci. Rep. 9:8218.1-8218.14(2019). // RX PubMed=2538684; RA Wang, Chen RA Curtis, John E. RA Minden, Mark David RA McCulloch, Ernest Armstrong RT "Expression of a retinoic acid receptor gene in myeloid leukemia RT cells."; RL Leukemia 3:264-269(1989). //