ID   Namalwa.CSN/70
AC   CVCL_1838
SY   NAMALWA.CSN/70; Namalwa CSN/70; NAMALWACSN70; CSN/70
DR   CLO; CLO_0007940
DR   CLDB; cl3638
DR   cancercelllines; CVCL_1838
DR   DSMZ; ACC-70
DR   DSMZCellDive; ACC-70
DR   Wikidata; Q54907452
RX   PubMed=1339415;
RX   PubMed=2298494;
RX   PubMed=3026962;
RX   PubMed=20454443;
RX   PubMed=28196595;
WW   http://www.cells-talk.com/index.php/page/copelibrary?key=CSN%2f70
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: African; Kenyan.
CC   Virology: Contains 2 integrated copies of EBV genome on chromosome 1.
CC   Virology: Infected by squirrel monkey retrovirus (SMRV) (PubMed=1339415; PubMed=20454443).
CC   Doubling time: ~40 hours (DSMZ=ACC-70).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Protein expression by reverse-phase protein arrays.
ST   Source(s): DSMZ
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11,12
ST   D16S539: 9
ST   D18S51: 15
ST   D19S433: 14,18
ST   D21S11: 27,28
ST   D2S1338: 17,21
ST   D3S1358: 16
ST   D5S818: 12,13
ST   D7S820: 11
ST   D8S1179: 13,15
ST   FGA: 22
ST   Penta D: 8,13
ST   Penta E: 5,15
ST   TH01: 7,9.3
ST   TPOX: 6,11
ST   vWA: 14
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0067 ! Namalwa
SX   Female
AG   Children
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 22
//
RX   PubMed=1339415; DOI=10.1002/ijc.2910520320;
RA   Middleton P.G., Miller S., Ross J.A., Steel C.M., Guy K.;
RT   "Insertion of SMRV-H viral DNA at the c-myc gene locus of a BL cell
RT   line and presence in established cell lines.";
RL   Int. J. Cancer 52:451-454(1992).
//
RX   PubMed=2298494; DOI=10.1002/ijc.2910450120;
RA   Guy K., Middleton P.G., Bansal N.S., Ross J.A., Steel C.M.;
RT   "Recurrent mutation of immunoglobulin and c-myc genes and differential
RT   expression of cell surface antigens occur in variant cell lines
RT   derived from a Burkitt lymphoma.";
RL   Int. J. Cancer 45:109-118(1990).
//
RX   PubMed=3026962;
RA   Guy K., Middleton P.G., Docherty L.J., De Angelis C.L., Steel C.M.;
RT   "MHC class II antigen and immunoglobulin expression in spontaneous
RT   phenotypic variants of the Burkitt's lymphoma cell line Namalwa.";
RL   Immunology 59:603-610(1986).
//
RX   PubMed=20454443; DOI=10.1155/2010/904767;
RA   Uphoff C.C., Denkmann S.A., Steube K.G., Drexler H.G.;
RT   "Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human
RT   and other primate cell lines.";
RL   J. Biomed. Biotechnol. 2010:904767.1-904767.23(2010).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//