ID   NALM-16
AC   CVCL_1834
SY   NALM16; Nalm-16
DR   BioSample; SAMN03473434
DR   cancercelllines; CVCL_1834
DR   Cosmic; 998707
DR   Cosmic; 999758
DR   Cosmic; 1037712
DR   DepMap; ACH-001993
DR   DSMZ; ACC-680
DR   DSMZCellDive; ACC-680
DR   GEO; GSM5137733
DR   PRIDE; PXD023662
DR   Wikidata; Q54907397
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=155647;
RX   PubMed=2140233;
RX   PubMed=2985879;
RX   PubMed=3159941;
RX   PubMed=3874327;
RX   PubMed=6582512;
RX   PubMed=6928235;
RX   PubMed=8847894;
RX   PubMed=9680106;
RX   PubMed=10739008;
RX   PubMed=11226526;
RX   PubMed=35354797;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: 36.7 hours (PubMed=8847894); ~36 hours (DSMZ=ACC-680).
CC   Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
ST   Source(s): DepMap=ACH-001993; DSMZ=ACC-680
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12
ST   D16S539: 13
ST   D18S51: 17,18
ST   D19S433: 13
ST   D21S11: 29,30 (DSMZ=ACC-680)
ST   D21S11: 30 (DepMap=ACH-001993)
ST   D2S1338: 18
ST   D3S1358: 15,17 (DSMZ=ACC-680)
ST   D3S1358: 17 (DepMap=ACH-001993)
ST   D5S818: 11
ST   D7S820: 10
ST   D8S1179: 14
ST   FGA: 20
ST   Penta D: 9,12.4 (DSMZ=ACC-680)
ST   Penta D: 9,13 (DepMap=ACH-001993)
ST   Penta E: 8
ST   TH01: 8
ST   TPOX: 11
ST   vWA: 17
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   12Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 28
//
RX   PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- III.
RT   Beta-hexosaminidase (E.C. 3.2.1.30).";
RL   Leuk. Res. 9:549-559(1985).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=8847894;
RA   Tani, Akiyoshi
RA   Tatsumi, Eiji
RA   Nakamura, Fumihiko
RA   Kumagai, Shunichi
RA   Kosaka, Yoshiyuki
RA   Sano, Kimihiko
RA   Nakamura, Hajime
RA   Amakawa, Ryuichi
RA   Ohno, Hitoshi
RT   "Sensitivity to dexamethasone and absence of bcl-2 protein in
RT   Burkitt's lymphoma cell line (Black93) derived from a patient with
RT   acute tumor lysis syndrome: comparative study with other BL and non-BL
RT   lines.";
RL   Leukemia 10:1592-1603(1996).
//
RX   PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2;
RA   Matsuo, Yoshinobu
RA   Drexler, Hans Gunther
RT   "Establishment and characterization of human B cell precursor-leukemia
RT   cell lines.";
RL   Leuk. Res. 22:567-579(1998).
//
RX   PubMed=6928235; DOI=10.1093/jnci/64.3.485;
RA   Kohno, Sei-ichi
RA   Minowada, Jun
RA   Sandberg, Avery Aba
RT   "Chromosome evolution of near-haploid clones in an established human
RT   acute lymphoblastic leukemia cell line (NALM-16).";
RL   J. Natl. Cancer Inst. 64:485-493(1980).
//
RX   PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720;
RA   Mattes, Michael Jules
RA   Cordon-Cardo, Carlos
RA   Lewis, John L. Jr.
RA   Old, Lloyd John
RA   Lloyd, Kenneth Oliver
RT   "Cell surface antigens of human ovarian and endometrial carcinoma
RT   defined by mouse monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984).
//
RX   PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900;
RA   Leo, Isabelle Rose
RA   Aswad, Luay
RA   Stahl, Matthias
RA   Kunold, Elena
RA   Post, Frederik
RA   Erkers, Tom
RA   Struyf, Nona
RA   Mermelekas, Georgios
RA   Joshi, Rubin Narayan
RA   Gracia-Villacampa, Eva
RA   Ostling, Paivi
RA   Kallioniemi, Olli-Pekka
RA   Pokrovskaja Tamm, Katja
RA   Siavelis, Ioannis
RA   Lehtio, Janne
RA   Vesterlund, Mattias
RA   Jafari, Rozbeh
RT   "Integrative multi-omics and drug response profiling of childhood
RT   acute lymphoblastic leukemia cell lines.";
RL   Nat. Commun. 13:1691.1-1691.19(2022).
//
RX   PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4;
RA   Inoue, Kaoru
RA   Kohno, Takashi
RA   Takakura, Satoshi
RA   Hayashi, Yasuhide
RA   Mizoguchi, Hideaki
RA   Yokota, Jun
RT   "Frequent microsatellite instability and BAX mutations in T cell acute
RT   lymphoblastic leukemia cell lines.";
RL   Leuk. Res. 24:255-262(2000).
//
RX   PubMed=2140233; DOI=10.1111/j.1440-1827.1990.tb01549.x;
RA   Nakano, Akinobu
RA   Harada, Takayuki
RA   Morikawa, Shigeru
RA   Kato, Yuzuru
RT   "Expression of leukocyte common antigen (CD45) on various human
RT   leukemia/lymphoma cell lines.";
RL   Acta Pathol. Jpn. 40:107-115(1990).
//
RX   PubMed=155647; PMCID=PMC1457255;
RA   Han, Tin
RA   Minowada, Jun
RT   "Use of stimulating capacity of mixed lymphocyte reaction (MLR-S) as a
RT   possible marker for the cell-origin of null-cell acute lymphoblastic
RT   leukaemia.";
RL   Immunology 35:333-339(1978).
//
RX   PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1;
RA   Inoue, Kaoru
RA   Kohno, Takashi
RA   Takakura, Satoshi
RA   Hayashi, Yasuhide
RA   Mizoguchi, Hideaki
RA   Yokota, Jun
RT   "Corrigendum to 'Frequent microsatellite instability and BAX mutations
RT   in T cell acute lymphoblastic leukemia cell lines' Leukemia Research 24
RT   (2000), 255-262.";
RL   Leuk. Res. 25:275-278(2001).
//
RX   PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cell lines -- 1.
RT   Carboxylic esterase.";
RL   Leuk. Res. 9:209-229(1985).
//
RX   PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x;
RA   Drexler, Hans Gunther
RA   Gaedicke, Gerhard
RA   Minowada, Jun
RT   "Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid
RT   phosphatase.";
RL   Leuk. Res. 9:537-548(1985).
//