ID   Karpas-1106P
AC   CVCL_1821
SY   Karpas-1106p; KARPAS-1106P; Karpas 1106P; KARPAS 1106P; KARPAS1106P; Karpas1106P; Karpas-1106; Karpas 1106; Karpas1106; K1106
DR   EFO; EFO_0006606
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03470811
DR   cancercelllines; CVCL_1821
DR   Cell_Model_Passport; SIDM01011
DR   ChEMBL-Cells; CHEMBL4523588
DR   ChEMBL-Targets; CHEMBL4523591
DR   Cosmic; 1013890
DR   Cosmic; 1278829
DR   Cosmic; 1289975
DR   Cosmic; 2276324
DR   Cosmic; 2297035
DR   Cosmic; 2437271
DR   Cosmic; 2479248
DR   Cosmic-CLP; 1327773
DR   DepMap; ACH-002254
DR   DSMZ; ACC-545
DR   DSMZCellDive; ACC-545
DR   ECACC; 06072607
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 1327773
DR   GEO; GSM119503
DR   GEO; GSM157143
DR   GEO; GSM380128
DR   GEO; GSM552445
DR   GEO; GSM1374584
DR   GEO; GSM1374585
DR   GEO; GSM1669973
DR   GEO; GSM1897961
DR   Lonza; 1123
DR   PharmacoDB; KARPAS1106P_727_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1821
DR   PubChem_Cell_line; CVCL_1821
DR   Wikidata; Q54899481
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=7849311;
RX   PubMed=7949096;
RX   PubMed=9724100;
RX   PubMed=16960149;
RX   PubMed=19278952;
RX   PubMed=20628145;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=30894373;
RX   PubMed=35839778;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
WW   Provider; Cambridge Enterprise; -; https://www.enterprise.cam.ac.uk/reagents/karpas-1106p-human-b-cell-non-hodgkins-lymphoma-cell-line/
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Caucasian.
CC   Doubling time: ~60-100 hours (ECACC=06072607).
CC   HLA typing: A*03:01,24:02; B*35:01,51:01; C*04:01,16:02; DQA1*03:02,05:01; DQB1*03:02,03:02; DRB1*03:17,03:17 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Gene deletion; HGNC; HGNC:16841; LITAF; Zygosity=Homozygous (PubMed=16960149).
CC   Sequence variation: Gene deletion; HGNC; HGNC:19383; SOCS1; Zygosity=Homozygous (PubMed=16960149).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.68%; Native American=0.48%; East Asian, North=0.25%; East Asian, South=1.18%; South Asian=11.86%; European, North=19.43%; European, South=65.12% (PubMed=30894373).
CC   Discontinued: DSMZ; ACC-545; true.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
CC   Cell type: B-cell; CL=CL_0000236.
ST   Source(s): Cosmic-CLP=1327773; DSMZ=ACC-545; ECACC=06072607; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 9,11
ST   D16S539: 9
ST   D18S51: 21
ST   D19S433: 14
ST   D21S11: 29,30
ST   D2S1338: 17,23
ST   D3S1358: 15
ST   D5S818: 8,14
ST   D7S820: 9,13
ST   D8S1179: 8,15
ST   FGA: 21,22
ST   Penta D: 8,11
ST   Penta E: 7
ST   TH01: 6
ST   TPOX: 9,11
ST   vWA: 18,20
DI   NCIt; C9280; Primary mediastinal (thymic) large B-cell lymphoma
DI   ORDO; Orphanet_98838; Primary mediastinal large B-cell lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_QY35 ! Karpas-1106A
SX   Female
AG   23Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 27-11-25; Version: 36
//
RX   PubMed=7949096; DOI=10.1182/blood.V84.10.3422.3422;
RA   Nacheva, Elisabeth
RA   Dyer, Martin John Swinnerton
RA   Metivier, C.
RA   Jadayel, Dalal Mouneimne
RA   Stranks, Gail
RA   Morilla, Ricardo
RA   Heward, Julie M.
RA   Holloway, Tracey L.
RA   O'Connor, S.
RA   Bevan, Philip C.
RA   Larsen, Christian-Jacques
RA   Karpas, Abraham
RT   "B-cell non-Hodgkin's lymphoma cell line (Karpas 1106) with complex
RT   translocation involving 18q21.3 but lacking BCL2 rearrangement and
RT   expression.";
RL   Blood 84:3422-3428(1994).
//
RX   PubMed=16960149; DOI=10.1182/blood-2006-06-026500;
RA   Mestre-Escorihuela, Cinta
RA   Rubio-Moscardo, Fanny
RA   Richter, Jose A.
RA   Siebert, Reiner
RA   Climent, Joan
RA   Fresquet, Vicente
RA   Beltran, Elena
RA   Agirre, Xabier
RA   Marugan, Isabel
RA   Marin, Miguel
RA   Rosenwald, Andreas
RA   Sugimoto, Kei-ji
RA   Wheat, Luise M.
RA   Karran, E. Loraine
RA   Garcia Garcia, Juan Fernando
RA   Sanchez-Verde, Lydia
RA   Prosper, Felipe
RA   Staudt, Louis Michael
RA   Pinkel, Daniel
RA   Dyer, Martin John Swinnerton
RA   Martinez-Climent, Jose Angel
RT   "Homozygous deletions localize novel tumor suppressor genes in B-cell
RT   lymphomas.";
RL   Blood 109:271-280(2007).
//
RX   PubMed=20628145; DOI=10.1182/blood-2010-05-282780; PMCID=PMC2995356;
RA   Green, Michael Richard
RA   Monti, Stefano
RA   Rodig, Scott J.
RA   Juszczynski, Przemyslaw
RA   Currie, Treeve
RA   O'Donnell, Evan
RA   Chapuy, Bjoern
RA   Takeyama, Kunihiko
RA   Neuberg, Donna
RA   Golub, Todd Robert
RA   Kutok, Jeffery L.
RA   Shipp, Margaret Ann
RT   "Integrative analysis reveals selective 9p24.1 amplification,
RT   increased PD-1 ligand expression, and further induction via JAK2 in
RT   nodular sclerosing Hodgkin lymphoma and primary mediastinal large
RT   B-cell lymphoma.";
RL   Blood 116:3268-3277(2010).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=7849311; DOI=10.1182/blood.V85.4.893.bloodjournal854893;
RA   Stranks, Gail
RA   Height, Susan E.
RA   Mitchell, Paul
RA   Jadayel, Dalal Mouneimne
RA   Yuille, Martin A.R.
RA   De Lord, Corinne F.M.
RA   Clutterbuck, Robyn D.
RA   Treleaven, Jennie G.
RA   Powles, Ray Leonard
RA   Nacheva, Elisabeth
RA   Oscier, David G.
RA   Karpas, Abraham
RA   Lenoir, Gilbert Marcel
RA   Smith, Stephen D.
RA   Millar, John L.
RA   Catovsky, Daniel
RA   Dyer, Martin John Swinnerton
RT   "Deletions and rearrangement of CDKN2 in lymphoid malignancy.";
RL   Blood 85:893-901(1995).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=9724100; DOI=10.1002/(SICI)1097-0215(19980925)78:1<100::AID-IJC16>3.0.CO;2-F;
RA   Tamura, Akiko
RA   Akagi, Tomoaki
RA   Nakazawa, Naozo
RA   Kashima, Kei
RA   Nakamura, Shigeo
RA   Karpas, Abraham
RA   Silverman, Gary A.
RA   Morishima, Yasuo
RA   Taniwaki, Masafumi
RA   Seto, Masao
RT   "Delineation of the breakpoint at 18q21.1 in a cell line (Karpas1106)
RT   derived from mediastinal B-cell lymphoma by fluorescence in situ
RT   hybridization with multiple YAC clones.";
RL   Int. J. Cancer 78:100-105(1998).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076;
RA   Li, Jun
RA   Zhao, Wei
RA   Akbani, Rehan
RA   Liu, Wen-Bin
RA   Ju, Zhen-Lin
RA   Ling, Shi-Yun
RA   Vellano, Christopher P.
RA   Roebuck, Paul
RA   Yu, Qing-Hua
RA   Eterovic, Agda Karina
RA   Byers, Lauren Averett
RA   Davies, Michael A.
RA   Deng, Wan-Leng
RA   Gopal, Y.N. Vashisht
RA   Chen, Guo
RA   von Euw, Erika Maria
RA   Slamon, Dennis Joseph
RA   Conklin, Dylan
RA   Heymach, John Victor
RA   Gazdar, Adi F.
RA   Minna, John D.
RA   Myers, Jeffrey N.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Liang, Han
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775;
RA   Goncalves, Emanuel
RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
RA   Barthorpe, Syd
RA   Manda, Srikanth S.
RA   Lucas, Natasha
RA   Beck, Alexandra
RA   Bucio-Noble, Daniel
RA   Dausmann, Michael
RA   Hall, Caitlin
RA   Hecker, Michael
RA   Koh, Jennifer
RA   Lightfoot, Howard
RA   Mahboob, Sadia
RA   Mali, Iman
RA   Morris, James
RA   Richardson, Laura
RA   Seneviratne, Akila J.
RA   Shepherd, Rebecca
RA   Sykes, Erin
RA   Thomas, Frances
RA   Valentini, Sara
RA   Williams, Steven G.
RA   Wu, Yang-Xiu
RA   Xavier, Dylan
RA   MacKenzie, Karen L.
RA   Hains, Peter G.
RA   Tully, Brett
RA   Robinson, Phillip James
RA   Zhong, Qing
RA   Garnett, Mathew J.
RA   Reddel, Roger Robert
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469;
RA   Iorio, Francesco
RA   Knijnenburg, Theo A.
RA   Vis, Daniel J.
RA   Bignell, Graham Robert
RA   Menden, Michael Patrick
RA   Schubert, Michael
RA   Aben, Nanne
RA   Goncalves, Emanuel
RA   Barthorpe, Syd
RA   Lightfoot, Howard
RA   Cokelaer, Thomas
RA   Greninger, Patricia
RA   van Dyk, Ewald
RA   Chang, Han
RA   de Silva, Heshani
RA   Heyn, Holger
RA   Deng, Xian-Ming
RA   Egan, Regina K.
RA   Liu, Qing-Song
RA   Mironenko, Tatiana
RA   Mitropoulos, Xeni
RA   Richardson, Laura
RA   Wang, Jin-Hua
RA   Zhang, Ting-Hu
RA   Moran, Sebastian
RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
RA   Saez-Rodriguez, Julio
RA   McDermott, Ultan
RA   Garnett, Mathew J.
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=19278952; DOI=10.1182/blood-2009-01-202028; PMCID=PMC3401058;
RA   Li, Cheng
RA   Kim, Sang-Woo
RA   Rai, Deepak
RA   Bolla, Aswani R.
RA   Adhvaryu, Siddharth
RA   Kinney, Marsha C.
RA   Robetorye, Ryan S.
RA   Aguiar, Ricardo C.T.
RT   "Copy number abnormalities, MYC activity, and the genetic fingerprint
RT   of normal B cells mechanistically define the microRNA profile of
RT   diffuse large B-cell lymphoma.";
RL   Blood 113:6681-6690(2009).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//