ID ALL-SIL AC CVCL_1805 SY ALLSIL; SIL-ALL; Sil-ALL DR BTO; BTO_0005360 DR CLO; CLO_0037168 DR EFO; EFO_0022414 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioSample; SAMN03473514 DR BioSample; SAMN10988449 DR cancercelllines; CVCL_1805 DR Cell_Model_Passport; SIDM00994 DR Cosmic; 721715 DR Cosmic; 913404 DR Cosmic; 933537 DR Cosmic; 996306 DR Cosmic; 998724 DR Cosmic; 1037687 DR Cosmic; 1115585 DR Cosmic; 1175126 DR Cosmic; 1224372 DR Cosmic; 1330498 DR Cosmic; 1524789 DR Cosmic; 1641391 DR Cosmic; 1664519 DR Cosmic; 1760517 DR Cosmic; 2165718 DR Cosmic; 2602907 DR Cosmic-CLP; 1295740 DR DepMap; ACH-000105 DR DSMZ; ACC-511 DR DSMZCellDive; ACC-511 DR EGA; EGAS00001000978 DR GDSC; 1295740 DR GEO; GSM1669597 DR GEO; GSM5137707 DR LiGeA; CCLE_156 DR LINCS_LDP; LCL-2059 DR PharmacoDB; ALLSIL_59_2019 DR PRIDE; PXD023662 DR PRIDE; PXD030304 DR Progenetix; CVCL_1805 DR Wikidata; Q54749231 RX DOI=10.1016/B978-0-12-221970-2.50457-5; RX PubMed=8127147; RX PubMed=8641406; RX PubMed=10071127; RX PubMed=10739008; RX PubMed=11226526; RX PubMed=14504097; RX PubMed=15361874; RX PubMed=15472075; RX PubMed=17117183; RX PubMed=22675565; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=30285677; RX PubMed=30629668; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=35354797; RX PubMed=35839778; WW Info; T-ALL cell lines db; -; https://humantallcelllines.wordpress.com/comprehensivetable/all-sil/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Population: Caucasian. CC Doubling time: 64 hours (PubMed=17117183); ~48 hours (DSMZ=ACC-511). CC HLA typing: A*02:01,30:02; B*14:02,15:01; C*03:03,08:02; DQB1*06:07;06:07; DRB1*15:01;15:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526; Sanger). CC Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:8064; NUP214; Name(s)=NUP214-ABL1; Note=NUP214 exon 32 fused to ABL1 exon 2 (PubMed=15361874; PubMed=35354797; DSMZ=ACC-511). CC Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1574Pro (c.4721T>C); Zygosity=Heterozygous (PubMed=15472075). CC Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2474fs*4 (c.7418_7419insGG); Zygosity=Heterozygous (PubMed=15472075). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Genome ancestry: African=1.38%; Native American=0%; East Asian, North=1.27%; East Asian, South=1.49%; South Asian=5.24%; European, North=39.53%; European, South=51.09% (PubMed=30894373). CC Misspelling: AL:L-SIL; Cosmic=913404. CC Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. CC Cell type: T-cell; CL=CL_0000084. ST Source(s): Cosmic-CLP=1295740; DSMZ=ACC-511 ST Amelogenin: X,Y ST CSF1PO: 10,12 ST D13S317: 9,12 ST D16S539: 10,12 ST D18S51: 13,16 ST D19S433: 12,17 ST D21S11: 29,31 ST D2S1338: 17,23 ST D3S1358: 14,16 ST D5S818: 11,13 ST D7S820: 11,12 ST D8S1179: 10 ST FGA: 21 ST Penta D: 10,15 ST Penta E: 7,17 ST TH01: 7,9.3 ST TPOX: 10,11 ST vWA: 17 DI NCIt; C7953; Childhood T acute lymphoblastic leukemia DI ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 17Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 41 // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=8127147; RA Heyman, Mats RA Grander, Dan RA Brondum-Nielsen, Karen RA Cederblad, Britta RA Liu, Yie RA Xu, Bo RA Einhorn, Stefan RT "Interferon system defects in malignant T-cells."; RL Leukemia 8:425-434(1994). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=10071127; DOI=10.1016/S0145-2126(98)00146-5; RA Kawamura, Machiko RA Ohnishi, Hiroaki RA Guo, Shu-Xia RA Sheng, Xiao-Ming RA Minegishi, Masayoshi RA Hanada, Ryoji RA Horibe, Keizo RA Hongo, Teruaki RA Kaneko, Yasuhiko RA Bessho, Fumio RA Yanagisawa, Masayoshi RA Sekiya, Takao RA Hayashi, Yasuhide RT "Alterations of the p53, p21, p16, p15 and RAS genes in childhood RT T-cell acute lymphoblastic leukemia."; RL Leuk. Res. 23:115-126(1999). // RX PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144; RA Uphoff, Cord C. RA Pommerenke, Claudia RA Denkmann, Sabine A. RA Drexler, Hans Gunther RT "Screening human cell lines for viral infections applying RNA-Seq data RT analysis."; RL PLoS ONE 14:e0210404.1-e0210404.22(2019). // RX PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1; RA Inoue, Kaoru RA Kohno, Takashi RA Takakura, Satoshi RA Hayashi, Yasuhide RA Mizoguchi, Hideaki RA Yokota, Jun RT "Corrigendum to 'Frequent microsatellite instability and BAX mutations RT in T cell acute lymphoblastic leukemia cell lines' Leukemia Research 24 RT (2000), 255-262."; RL Leuk. Res. 25:275-278(2001). // RX PubMed=8641406; DOI=10.1111/j.1600-0609.1996.tb00721.x; RA Borgonovo-Brandter, Laura RA Heyman, Mats RA Rasool, Omid RA Liu, Yie RA Grander, Dan RA Einhorn, Stefan RT "p16INK4/p15INK4B gene inactivation is a frequent event in malignant RT T-cell lines."; RL Eur. J. Haematol. 56:313-318(1996). // RX PubMed=17117183; DOI=10.1038/sj.bjc.6603447; PMCID=PMC2360743; RA Beesley, Alex H. RA Palmer, Misty-Lee RA Ford, Jette RA Weller, Richard E. RA Cummings, Aaron J. RA Freitas, Joseph R. RA Firth, Martin J. RA Perera, Kanchana U. RA de Klerk, Nick H. RA Kees, Ursula R. RT "Authenticity and drug resistance in a panel of acute lymphoblastic RT leukaemia cell lines."; RL Br. J. Cancer 95:1537-1544(2006). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=15361874; DOI=10.1038/ng1425; RA Graux, Carlos RA Cools, Jan RA Melotte, Cindy RA Quentmeier, Hilmar RA Ferrando, Adolfo A. RA Levine, Ross RA Vermeesch, Joris R. RA Stul, Michel RA Dutta, Binita RA Boeckx, Nancy RA Bosly, Andre RA Heimann, Pierre RA Uyttebroeck, Anne RA Mentens, Nicole RA Somers, Riet RA MacLeod, Roderick A.F. RA Drexler, Hans Gunther RA Look, Alfred Thomas RA Gilliland, Dwight Gary RA Michaux, Lucienne RA Vandenberghe, Peter RA Wlodarska, Iwona RA Marynen, Peter RA Hagemeijer, Anne RT "Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute RT lymphoblastic leukemia."; RL Nat. Genet. 36:1084-1089(2004). // RX PubMed=14504097; DOI=10.1182/blood-2003-02-0418; RA Taketani, Takeshi RA Taki, Tomohiko RA Sugita, Kanji RA Furuichi, Yoshiyuki RA Ishii, Eiichi RA Hanada, Ryoji RA Tsuchida, Masahiro RA Sugita, Kenichi RA Ida, Kohmei RA Hayashi, Yasuhide RT "FLT3 mutations in the activation loop of tyrosine kinase domain are RT frequently found in infant ALL with MLL rearrangements and pediatric RT ALL with hyperdiploidy."; RL Blood 103:1085-1088(2004). // RX PubMed=22675565; DOI=10.1371/journal.pone.0038463; PMCID=PMC3366948; RA Atak, Zeynep Kalender RA De Keersmaecker, Kim RA Gianfelici, Valentina RA Geerdens, Ellen RA Vandepoel, Roel RA Pauwels, Daphnie RA Porcu, Michael RA Lahortiga, Idoya RA Brys, Vanessa RA Dirks, Wilhelm Gerhard RA Quentmeier, Hilmar RA Cloos, Jacqueline RA Cuppens, Harry RA Uyttebroeck, Anne RA Vandenberghe, Peter RA Cools, Jan RA Aerts, Stein RT "High accuracy mutation detection in leukemia on a selected panel of RT cancer genes."; RL PLoS ONE 7:e38463.1-e38463.11(2012). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX DOI=10.1016/B978-0-12-221970-2.50457-5; RA Drexler, Hans Gunther RT "The leukemia-lymphoma cell line factsbook."; RL (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001). // RX PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4; RA Inoue, Kaoru RA Kohno, Takashi RA Takakura, Satoshi RA Hayashi, Yasuhide RA Mizoguchi, Hideaki RA Yokota, Jun RT "Frequent microsatellite instability and BAX mutations in T cell acute RT lymphoblastic leukemia cell lines."; RL Leuk. Res. 24:255-262(2000). // RX PubMed=15472075; DOI=10.1126/science.1102160; RA Weng, Andrew P. RA Ferrando, Adolfo A. RA Lee, Woojoong RA Morris, John P. 4th RA Silverman, Lewis B. RA Sanchez-Irizarry, Cheryll RA Blacklow, Stephen Charles RA Look, Alfred Thomas RA Aster, Jon Christopher RT "Activating mutations of NOTCH1 in human T cell acute lymphoblastic RT leukemia."; RL Science 306:269-271(2004). // RX PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786; RA Tan, Kar-Tong RA Ding, Ling-Wen RA Sun, Qiao-Yang RA Lao, Zhen-Tang RA Chien, Wenwen RA Ren, Xi RA Xiao, Jin-Fen RA Loh, Xin-Yi RA Xu, Liang RA Lill, Michael RA Mayakonda, Anand RA Lin, De-Chen RA Yang, Henry He RA Koeffler, Harold Phillip RT "Profiling the B/T cell receptor repertoire of lymphocyte derived cell RT lines."; RL BMC Cancer 18:940.1-940.13(2018). // RX PubMed=35354797; DOI=10.1038/s41467-022-29224-5; PMCID=PMC8967900; RA Leo, Isabelle Rose RA Aswad, Luay RA Stahl, Matthias RA Kunold, Elena RA Post, Frederik RA Erkers, Tom RA Struyf, Nona RA Mermelekas, Georgios RA Joshi, Rubin Narayan RA Gracia-Villacampa, Eva RA Ostling, Paivi RA Kallioniemi, Olli-Pekka RA Pokrovskaja Tamm, Katja RA Siavelis, Ioannis RA Lehtio, Janne RA Vesterlund, Mattias RA Jafari, Rozbeh RT "Integrative multi-omics and drug response profiling of childhood RT acute lymphoblastic leukemia cell lines."; RL Nat. 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