ID   VMRC-LCP
AC   CVCL_1788
SY   VMRCLCP; Patton; Virginia Mason Research Center-Lung Cancer P
DR   CLO; CLO_0037045
DR   BioSample; SAMN03470791
DR   BioSample; SAMN10987738
DR   cancercelllines; CVCL_1788
DR   Cell_Model_Passport; SIDM01904
DR   CGH-DB; 193-1
DR   CGH-DB; 9177-4
DR   ChEMBL-Cells; CHEMBL3308808
DR   ChEMBL-Targets; CHEMBL1075608
DR   Cosmic; 889101
DR   Cosmic; 930300
DR   Cosmic; 1066175
DR   DepMap; ACH-001234
DR   GEO; GSM827200
DR   GEO; GSM1374986
DR   IARC_TP53; 28370
DR   JCRB; JCRB0103
DR   LINCS_LDP; LCL-1594
DR   PharmacoDB; VMRCLCP_1656_2019
DR   Progenetix; CVCL_1788
DR   PubChem_Cell_line; CVCL_1788
DR   Wikidata; Q54993283
RX   PubMed=4005855;
RX   PubMed=9290701;
RX   PubMed=14581340;
RX   PubMed=15185009;
RX   PubMed=15746151;
RX   PubMed=20164919;
RX   PubMed=20215515;
RX   PubMed=24002593;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   From: Bean, Michael A.; Virginia Mason Research Center; Seattle; USA.
CC   Population: Caucasian.
CC   Doubling time: 93 hours (Note=Lot 082994), ~79 hours (Note=Lot 11132014) (JCRB=JCRB0103).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val157Phe (c.469G>T); ClinVar=VCV000012353; Zygosity=Homozygous (DepMap=ACH-001234).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=0.95%; Native American=0%; East Asian, North=1.52%; East Asian, South=0%; South Asian=0.62%; European, North=62.75%; European, South=34.15% (PubMed=30894373).
CC   Misspelling: VMR-LCP; Cosmic=889101.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): JCRB=JCRB0103
ST   Amelogenin: X
ST   CSF1PO: 10
ST   D16S539: 12
ST   D5S818: 13
ST   D7S820: 10,12
ST   TH01: 7
ST   TPOX: 8
ST   vWA: 18,20
DI   NCIt; C3493; Lung squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 35
//
RX   PubMed=14581340;
RA   Yokoi, Sana
RA   Yasui, Kohichiroh
RA   Iizasa, Toshihiko
RA   Imoto, Issei
RA   Fujisawa, Takehiko
RA   Inazawa, Johji
RT   "TERC identified as a probable target within the 3q26 amplicon that is
RT   detected frequently in non-small cell lung cancers.";
RL   Clin. Cancer Res. 9:4705-4713(2003).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia, Li-Qun
RA   Osada, Motonobu
RA   Ishioka, Chikashi
RA   Gamo, Makio
RA   Ikawa, Shuntaro
RA   Suzuki, Takao
RA   Shimodaira, Hideki
RA   Niitani, Tomohito
RA   Kudo, Toshio
RA   Akiyama, Mitoshi
RA   Kimura, Narimiti
RA   Matsuo, Mitsuyoshi
RA   Mizusawa, Hiroshi
RA   Tanaka, Noriho
RA   Koyama, Hideki
RA   Namba, Masayoshi
RA   Kanamaru, Ryunosuke
RA   Kuroki, Toshio
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=24002593; DOI=10.1038/bjc.2013.452; PMCID=PMC3776976;
RA   Wu, Di
RA   Pang, Yi
RA   Wilkerson, Matthew D.
RA   Wang, Die
RA   Hammerman, Peter S.
RA   Liu, Jun S.
RT   "Gene-expression data integration to squamous cell lung cancer
RT   subtypes reveals drug sensitivity.";
RL   Br. J. Cancer 109:1599-1608(2013).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103;
RA   Ghandi, Mahmoud
RA   Huang, Franklin W.
RA   Jane-Valbuena, Judit
RA   Kryukov, Gregory V.
RA   Lo, Christopher C.
RA   McDonald, E. Robert 3rd
RA   Barretina, Jordi Ginesta
RA   Gelfand, Ellen T.
RA   Bielski, Craig M.
RA   Li, Hao-Xin
RA   Hu, Kevin
RA   Andreev-Drakhlin, Alexander Y.
RA   Kim, Jaegil
RA   Hess, Julian M.
RA   Haas, Brian J.
RA   Aguet, Francois
RA   Weir, Barbara A.
RA   Rothberg, Michael V.
RA   Paolella, Brenton R.
RA   Lawrence, Michael Scott
RA   Akbani, Rehan
RA   Lu, Yi-Ling
RA   Tiv, Hong L.
RA   Gokhale, Prafulla C.
RA   de Weck, Antoine
RA   Mansour, Ali Amin
RA   Oh, Coyin
RA   Shih, Juliann
RA   Hadi, Kevin
RA   Rosen, Yanay
RA   Bistline, Jonathan
RA   Venkatesan, Kavitha
RA   Reddy, Anupama
RA   Sonkin, Dmitriy
RA   Liu, Manway
RA   Lehar, Joseph
RA   Korn, Joshua M.
RA   Porter, Dale A.
RA   Jones, Michael D.
RA   Golji, Javad
RA   Caponigro, Giordano
RA   Taylor, Jordan E.
RA   Dunning, Caitlin M.
RA   Creech, Amanda L.
RA   Warren, Allison C.
RA   McFarland, James M.
RA   Zamanighomi, Mahdi
RA   Kauffmann, Audrey
RA   Stransky, Nicolas
RA   Imielinski, Marcin
RA   Maruvka, Yosef E.
RA   Cherniack, Andrew D.
RA   Tsherniak, Aviad
RA   Vazquez, Francisca
RA   Jaffe, Jacob D.
RA   Lane, Andrew Alan
RA   Weinstock, David M.
RA   Johannessen, Cory M.
RA   Morrissey, Michael P.
RA   Stegmeier, Frank
RA   Schlegel, Robert
RA   Hahn, William Chun
RA   Getz, Gad
RA   Mills, Gordon B.
RA   Boehm, Jesse S.
RA   Golub, Todd Robert
RA   Garraway, Levi Alexander
RA   Sellers, William Raj
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=15185009; DOI=10.1007/s00262-004-0533-9; PMCID=PMC11034254;
RA   Yamaji, Haruko
RA   Iizasa, Toshihiko
RA   Koh, Eitetsu
RA   Suzuki, Makoto
RA   Otsuji, Mizuto
RA   Chang, Hao
RA   Motohashi, Shinichiro
RA   Yokoi, Sana
RA   Hiroshima, Kenzo
RA   Tagawa, Masatoshi
RA   Nakayama, Toshinori
RA   Fujisawa, Takehiko
RT   "Correlation between interleukin 6 production and tumor proliferation
RT   in non-small cell lung cancer.";
RL   Cancer Immunol. Immunother. 53:786-792(2004).
//
RX   PubMed=15746151; DOI=10.1093/hmg/ddi092;
RA   Izumi, Hiroto
RA   Inoue, Jun
RA   Yokoi, Sana
RA   Hosoda, Hiroshi
RA   Shibata, Tatsuhiro
RA   Sunamori, Makoto
RA   Hirohashi, Setsuo
RA   Inazawa, Johji
RA   Imoto, Issei
RT   "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in
RT   non-small cell lung cancers.";
RL   Hum. Mol. Genet. 14:997-1007(2005).
//
RX   PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113;
RA   Bignell, Graham Robert
RA   Greenman, Christopher D.
RA   Davies, Helen R.
RA   Butler, Adam P.
RA   Edkins, Sarah
RA   Andrews, Jenny M.
RA   Buck, Gemma
RA   Chen, Lina
RA   Beare, David
RA   Latimer, Calli
RA   Widaa, Sara
RA   Hinton, Jonathan
RA   Fahey, Ciara
RA   Fu, Bei-Yuan
RA   Swamy, Sajani
RA   Dalgliesh, Gillian L.
RA   Teh, Bin Tean
RA   Deloukas, Panos
RA   Yang, Feng-Tang
RA   Campbell, Peter J.
RA   Futreal, P. Andrew
RA   Stratton, Michael Rudolf
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//
RX   PubMed=4005855;
RA   Kyoizumi, Seishi
RA   Akiyama, Mitoshi
RA   Kouno, Nobuoki
RA   Kobuke, Kyoko
RA   Hakoda, Masayuki
RA   Jones, Stephen L.
RA   Yamakido, Michio
RT   "Monoclonal antibodies to human squamous cell carcinoma of the lung
RT   and their application to tumor diagnosis.";
RL   Cancer Res. 45:3274-3281(1985).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg, S. Michael
RA   Mohapatra, Gayatry
RA   Rivera, Miguel N.
RA   Winokur, Daniel
RA   Greninger, Patricia
RA   Nitta, Mai
RA   Sadow, Peter M.
RA   Sooriyakumar, Gaya
RA   Brannigan, Brian W.
RA   Ulman, Matthew J.
RA   Perera, Rushika M.
RA   Wang, Rui
RA   Tam, Angela
RA   Ma, Xiao-Jun
RA   Erlander, Mark
RA   Sgroi, Dennis C.
RA   Rocco, James W.
RA   Lingen, Mark W.
RA   Cohen, Ezra E.W.
RA   Louis, David Neil
RA   Settleman, Jeffrey
RA   Haber, Daniel Arie
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//