ID   TK-10
AC   CVCL_1773
SY   TK.10; TK_10; TK 10; TK10
DR   BTO; BTO_0004283
DR   CLO; CLO_0009983
DR   EFO; EFO_0006765
DR   ArrayExpress; E-MTAB-783
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03473277
DR   cancercelllines; CVCL_1773
DR   Cell_Model_Passport; SIDM00113
DR   ChEMBL-Cells; CHEMBL3308453
DR   ChEMBL-Targets; CHEMBL614056
DR   Cosmic; 687944
DR   Cosmic; 845925
DR   Cosmic; 905980
DR   Cosmic; 974308
DR   Cosmic; 1092642
DR   Cosmic; 1305378
DR   Cosmic; 1312366
DR   Cosmic; 1998485
DR   Cosmic-CLP; 905980
DR   DepMap; ACH-001208
DR   EGA; EGAS00001000610
DR   EGA; EGAS00001000978
DR   GDSC; 905980
DR   GEO; GSM2119
DR   GEO; GSM50231
DR   GEO; GSM50295
DR   GEO; GSM743486
DR   GEO; GSM750807
DR   GEO; GSM799440
DR   GEO; GSM844717
DR   GEO; GSM847165
DR   GEO; GSM1153450
DR   GEO; GSM1181308
DR   GEO; GSM1181326
DR   GEO; GSM1670545
DR   GEO; GSM2124690
DR   IARC_TP53; 18078
DR   LINCS_LDP; LCL-1771
DR   NCI-DCTD; TK-10
DR   PharmacoDB; TK10_1597_2019
DR   PRIDE; PXD003539
DR   PRIDE; PXD005942
DR   PRIDE; PXD005946
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_1773
DR   PubChem_Cell_line; CVCL_1773
DR   SKY/M-FISH/CGH; 2807
DR   Wikidata; Q54972524
RX   PubMed=2041050;
RX   PubMed=3594443;
RX   PubMed=9331090;
RX   PubMed=10700174;
RX   PubMed=10723130;
RX   PubMed=15748285;
RX   PubMed=17088437;
RX   PubMed=18277095;
RX   PubMed=19372543;
RX   PubMed=20164919;
RX   PubMed=22068913;
RX   PubMed=22347499;
RX   PubMed=22384151;
RX   PubMed=22628656;
RX   PubMed=23856246;
RX   PubMed=23933261;
RX   PubMed=24279929;
RX   PubMed=24670534;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=27377824;
RX   PubMed=27397505;
RX   PubMed=27807467;
RX   PubMed=27993170;
RX   PubMed=28196595;
RX   PubMed=28489074;
RX   PubMed=30894373;
RX   PubMed=31733513;
RX   PubMed=35839778;
RX   PubMed=38861359;
WW   Info; MCLP; -; https://tcpaportal.org/mclp/
WW   Info; NCI DTP; NCI-60; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm
WW   Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=42
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Part of: NCI-60 cancer cell line panel.
CC   Doubling time: 25 hours (Note=At 155th passage) (PubMed=3594443); 51.3 hours (NCI-DCTD=TK-10).
CC   HLA typing: A*33:01; B*14:02; C*08:02; DPB1*04:02; DQB1*05:01:01; DRB1*01:02:01 (PubMed=15748285).
CC   HLA typing: A*33:01,33:01; B*14:02,14:02; C*08:02,08:02; DQB1*05:01,05:01; DRB1*01:02,01:02 (PubMed=26589293).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Leu264Arg (c.791T>G); Zygosity=Heterozygous (PubMed=9331090; PubMed=17088437; PubMed=18277095; Cosmic-CLP=905980; DepMap=ACH-001208).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Metabolomics.
CC   Omics: Phenotyping; Drug screening.
CC   Omics: Phenotyping; Fluorescent probe library screening.
CC   Omics: Proteomics.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Proteomics; Quantitative.
CC   Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
CC   Genome ancestry: African=1.52%; Native American=2.2%; East Asian, North=0.11%; East Asian, South=1.52%; South Asian=12.26%; European, North=9%; European, South=73.4% (PubMed=30894373).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): Cosmic-CLP=905980; PubMed=19372543; PubMed=25877200
ST   Amelogenin: X (PubMed=19372543)
ST   Amelogenin: X,Y (Cosmic-CLP=905980; PubMed=25877200)
ST   CSF1PO: 12
ST   D13S317: 9
ST   D16S539: 12
ST   D18S51: 16 (PubMed=19372543)
ST   D18S51: 16,17 (PubMed=25877200)
ST   D19S433: 14,15
ST   D21S11: 29
ST   D2S1338: 17
ST   D3S1358: 15,17
ST   D5S818: 11,12
ST   D7S820: 10,11
ST   D8S1179: 15,16
ST   FGA: 18,22
ST   Penta D: 10
ST   Penta E: 10
ST   TH01: 8
ST   TPOX: 11
ST   vWA: 18,19
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   43Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 25-06-26; Version: 44
//
RX   PubMed=22628656; DOI=10.1126/science.1218595; PMCID=PMC3526189;
RA   Jain, Mohit
RA   Nilsson, Roland
RA   Sharma, Sonia
RA   Madhusudhan, Nikhil
RA   Kitami, Toshimori
RA   Souza, Amanda L.
RA   Kafri, Ran
RA   Kirschner, Marc Wallace
RA   Clish, Clary B.
RA   Mootha, Vamsi Krishna
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RT   cancer cell proliferation.";
RL   Science 336:1040-1044(2012).
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RA   Adams, Sharon
RA   Robbins, Fu-Meei
RA   Chen, Deborah
RA   Wagage, Devika
RA   Holbeck, Susan L.
RA   Morse, Herbert Carpenter 3rd
RA   Stroncek, David
RA   Marincola, Francesco M.
RT   "HLA class I and II genotype of the NCI-60 cell lines.";
RL   J. Transl. Med. 3:11.1-11.8(2005).
//
RX   PubMed=2041050; DOI=10.1093/jnci/83.11.757;
RA   Monks, Anne
RA   Scudiero, Dominic A.
RA   Skehan, Philip
RA   Shoemaker, Robert H.
RA   Paull, Kenneth D.
RA   Vistica, David T.
RA   Hose, Curtis D.
RA   Langley, John
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RT   "Feasibility of a high-flux anticancer drug screen using a diverse
RT   panel of cultured human tumor cell lines.";
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RA   Poulos, Rebecca C.
RA   Cai, Zhao-Xiang
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RA   Lucas, Natasha
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RA   Lightfoot, Howard
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RA   Richardson, Laura
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RA   Liang, Han
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RT   arrays.";
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//
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RA   Butler, Adam P.
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RA   Fahey, Ciara
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RA   Swamy, Sajani
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RA   Alimov, Andrei
RA   Kost-Alimova, Maria
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RA   Li, Chun-De
RA   Bergerheim, Ulf S.R.
RA   Imreh, Stefan
RA   Klein, George
RA   Zabarovsky, Eugene R.
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RT   deletions in renal cell carcinoma.";
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//
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RA   Moghaddas Gholami, Amin
RA   Hahne, Hannes
RA   Wu, Zhi-Xiang
RA   Auer, Florian Johann
RA   Meng, Chen
RA   Wilhelm, Mathias
RA   Kuster, Bernhard
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RL   Cell Rep. 4:609-620(2013).
//
RX   PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921; PMCID=PMC4020356;
RA   Lorenzi, Philip L.
RA   Reinhold, William C.
RA   Varma, Sudhir
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RA   Weinstein, John N.
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RA   Schubert, Michael
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RA   Barthorpe, Syd
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RA   Mitropoulos, Xeni
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RA   Sayols, Sergi
RA   Soleimani, Maryam
RA   Tamborero, David
RA   Lopez-Bigas, Nuria
RA   Ross-Macdonald, Petra
RA   Esteller, Manel
RA   Gray, Nathanael S.
RA   Haber, Daniel Arie
RA   Stratton, Michael Rudolf
RA   Benes, Cyril Henri
RA   Wessels, Lodewyk F.A.
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RA   Liu, Wei
RA   Sun, Yao-Ting
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RA   Menden, Michael Patrick
RA   Xu, Chao
RA   Calzone, Laurence
RA   Martignetti, Loredana
RA   Auwerx, Chiara
RA   Buljan, Marija
RA   Banaei-Esfahani, Amir
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RA   Zhong, Qing
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RA   Zhang, Qiu-Shi
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RA   Bork, Peer
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//
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//
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RA   Qiu, Jean
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RT   protein synthesis rates.";
RL   Cancer Metab. 1:20.1-20.13(2013).
//
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RA   Hellemans, Jan
RA   Vandesompele, Jo
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RT   line panel using high-throughput RT-qPCR.";
RL   Sci. Data 3:160052.1-160052.6(2016).
//
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RA   Varma, Sudhir
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RA   Weinstein, John N.
RA   Reinhold, William C.
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RA   Szczylik, Cezary
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//
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RA   Gillet, Jean-Pierre
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RA   Green, Lisa J.
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RA   Patel, Chirayu
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RA   Singal, Vineet
RA   Padmanabhan, Raji
RA   Davidson, Ben
RA   Ganapathi, Ram
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//
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RA   Davis, Sean R.
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RA   Doroshow, James H.
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RT   and systems pharmacology.";
RL   Cancer Res. 73:4372-4382(2013).
//
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RA   Ruan, Xiao-Yang
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RA   Reinhold, William C.
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RT   compared to HapMap trios, and relation to fragile site location.";
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//
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RA   Yang, Wan Rou
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RT   panel.";
RL   Mob. DNA 7:20.1-20.11(2016).
//
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RA   Ikediobi, Ogechi N.
RA   Davies, Helen R.
RA   Bignell, Graham Robert
RA   Edkins, Sarah
RA   Stevens, Claire
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RA   Avis, Tim
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RA   Cole, Jennifer
RA   Dicks, Ed
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RA   Halliday, Kelly
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RA   Hinton, Jonathan
RA   Hunter, Chris
RA   Jenkinson, Andy
RA   Jones, David
RA   Kosmidou, Vivian
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RA   Raine, Keiran Martin
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RA   Smith, Raffaella
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RA   West, Sofie
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RA   Weinstein, John N.
RA   Stratton, Michael Rudolf
RA   Futreal, P. Andrew
RA   Wooster, Richard
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RT   set.";
RL   Mol. Cancer Ther. 5:2606-2612(2006).
//
RX   PubMed=18277095; DOI=10.4161/cbt.7.5.5712;
RA   Berglind, Hanna
RA   Pawitan, Yudi
RA   Kato, Shunsuke
RA   Ishioka, Chikashi
RA   Soussi, Thierry
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RT   paradigm for cell line cross-contamination.";
RL   Cancer Biol. Ther. 7:699-708(2008).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675;
RA   Dutil, Julie
RA   Chen, Zhi-Hua
RA   Monteiro, Alvaro N.A.
RA   Teer, Jamie K.
RA   Eschrich, Steven A.
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RT   ancestry in cancer cell lines.";
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//
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RT   the National Cancer Institute anticancer drug screen and correlations
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//