ID SW900 AC CVCL_1731 SY SW-900; SW 900 DR BTO; BTO_0004611 DR CLO; CLO_0009202 DR EFO; EFO_0002374 DR ArrayExpress; E-MTAB-38 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; HTB-59 DR BioSample; SAMN03472972 DR BioSample; SAMN10987793 DR cancercelllines; CVCL_1731 DR Cell_Model_Passport; SIDM01158 DR ChEMBL-Cells; CHEMBL3308819 DR ChEMBL-Targets; CHEMBL1075597 DR Cosmic; 724879 DR Cosmic; 933582 DR Cosmic; 1071890 DR Cosmic; 1176591 DR Cosmic; 1608837 DR Cosmic; 1995656 DR Cosmic; 2060528 DR Cosmic-CLP; 724879 DR DepMap; ACH-000669 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 724879 DR GEO; GSM63352 DR GEO; GSM784255 DR GEO; GSM827522 DR GEO; GSM887680 DR GEO; GSM888772 DR GEO; GSM1670515 DR IARC_TP53; 27254 DR IGRhCellID; SW900 DR KCLB; 30059 DR LiGeA; CCLE_258 DR LINCS_LDP; LCL-1593 DR PharmacoDB; SW900_1548_2019 DR Progenetix; CVCL_1731 DR PubChem_Cell_line; CVCL_1731 DR Wikidata; Q54971217 RX PubMed=327080; RX PubMed=833871; RX PubMed=924690; RX PubMed=3518877; RX PubMed=6935474; RX PubMed=7459858; RX PubMed=7736387; RX PubMed=12068308; RX PubMed=16187286; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=24002593; RX PubMed=24135919; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=29444439; RX PubMed=30894373; RX PubMed=31068700; RX PubMed=31395879; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: NCI RAS program mutant KRAS cell line panel. CC Part of: TCGA-110-CL cell line panel. CC From: Scott and White Clinic; Temple; USA. CC Population: Caucasian. CC HLA typing: A*33:01,33:01; B*14:02,14:02; C*08:02,08:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Heterozygous (PubMed=12068308; Cosmic-CLP=724879). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gln167Ter (c.499C>T); ClinVar=VCV000528250; Zygosity=Homozygous (Cosmic-CLP=724879). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics. CC Omics: Proteomics; PTM; Phosphorylation. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.45%; Native American=0%; East Asian, North=1.4%; East Asian, South=0%; South Asian=1.83%; European, North=65.68%; European, South=30.63% (PubMed=30894373). CC Derived from site: In situ; Lung; UBERON=UBERON_0002048. ST Source(s): ATCC=HTB-59; Cosmic-CLP=724879; KCLB=30059; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 11 ST D13S317: 8 ST D16S539: 11 ST D18S51: 19 ST D19S433: 14 ST D21S11: 29,31 ST D2S1338: 20,27 ST D3S1358: 14 ST D5S818: 11 ST D7S820: 11,12 ST D8S1179: 11,16 ST FGA: 21,23 ST Penta D: 9,12 ST Penta E: 14,15 ST TH01: 8 ST TPOX: 11 ST vWA: 16 DI NCIt; C3493; Lung squamous cell carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 53Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 40 // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=6935474; DOI=10.1093/jnci/66.2.239; RA Wright, William C. RA Daniels, Walter P. RA Fogh, Jorgen RT "Distinction of seventy-one cultured human tumor cell lines by RT polymorphic enzyme analysis."; RL J. Natl. Cancer Inst. 66:239-247(1981). // RX PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051; PMCID=PMC6343826; RA Yuan, Tina L. RA Amzallag, Arnaud RA Bagni, Rachel RA Yi, Ming RA Afghani, Shervin RA Burgan, William RA Fer, Nicole RA Strathern, Leslie A. RA Powell, Katie RA Smith, Brian RA Waters, Andrew Michael RA Drubin, David Alan RA Thomson, Ty RA Liao, Rosy RA Greninger, Patricia RA Stein, Giovanna T. RA Murchie, Ellen RA Cortez, Eliane RA Egan, Regina K. RA Procter, Lauren RA Bess, Matthew RA Cheng, Kwong Tai RA Lee, Chih-Shia RA Lee, Liam Changwoo RA Fellmann, Christof RA Stephens, Robert RA Luo, Ji RA Lowe, Scott William RA Benes, Cyril Henri RA McCormick, Frank RT "Differential effector engagement by oncogenic KRAS."; RL Cell Rep. 22:1889-1902(2018). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=12068308; DOI=10.1038/nature00766; RA Davies, Helen R. RA Bignell, Graham Robert RA Cox, Charles RA Stephens, Philip J. RA Edkins, Sarah RA Clegg, Sheila RA Teague, Jon W. RA Woffendin, Hayley RA Garnett, Mathew J. RA Bottomley, William RA Davis, Neil RA Dicks, Ed RA Ewing, Rebecca RA Floyd, Yvonne RA Gray, Kristian RA Hall, Sarah RA Hawes, Rachel RA Hughes, Jaime RA Kosmidou, Vivian RA Menzies, Andrew RA Mould, Catherine RA Parker, Adrian RA Stevens, Claire RA Watt, Stephen RA Hooper, Steven RA Wilson, Rebecca RA Jayatilake, Hiran RA Gusterson, Barry Austin RA Cooper, Colin S. RA Shipley, Janet M. RA Hargrave, Darren RA Pritchard-Jones, Kathryn RA Maitland, Norman J. RA Chenevix-Trench, Georgia RA Riggins, Gregory J. RA Bigner, Darell Doty RA Palmieri, Giuseppe RA Cossu, Antonio RA Flanagan, Adrienne Margaret RA Nicholson, Andrew RA Ho, Judy W.C. RA Leung, Suet Yi RA Yuen, Siu Tsan RA Weber, Barbara L. RA Seigler, Hilliard Foster RA Darrow, Timothy L. RA Paterson, Hugh F. RA Marais, Richard RA Marshall, Christopher John RA Wooster, Richard RA Stratton, Michael Rudolf RA Futreal, P. Andrew RT "Mutations of the BRAF gene in human cancer."; RL Nature 417:949-954(2002). // RX PubMed=31395879; DOI=10.1038/s41467-019-11415-2; PMCID=PMC6687785; RA Yu, Katharine RA Chen, Bin RA Aran, Dvir RA Charalel, Joe RA Yau, Christina RA Wolf, Douglas M. RA van 't Veer, Laura J. RA Butte, Atul Janardhan RA Goldstein, Ted RA Sirota, Marina RT "Comprehensive transcriptomic analysis of cell lines as models of RT primary tumors across 22 tumor types."; RL Nat. Commun. 10:3574.1-3574.11(2019). // RX PubMed=24135919; DOI=10.1038/ncomms3617; PMCID=PMC4107456; RA Balbin, O. Alejandro RA Prensner, John R. RA Sahu, Anirban RA Yocum, Anastasia RA Shankar, Sunita RA Malik, Rohit RA Fermin, Damian RA Dhanasekaran, Saravana M. RA Chandler, Benjamin RA Thomas, Dafydd RA Beer, David G. RA Cao, Xu-Hong RA Nesvizhskii, Alexey I. RA Chinnaiyan, Arul M. RT "Reconstructing targetable pathways in lung cancer by integrating RT diverse omics data."; RL Nat. Commun. 4:2617.1-2617.13(2013). // RX PubMed=24002593; DOI=10.1038/bjc.2013.452; PMCID=PMC3776976; RA Wu, Di RA Pang, Yi RA Wilkerson, Matthew D. RA Wang, Die RA Hammerman, Peter S. RA Liu, Jun S. RT "Gene-expression data integration to squamous cell lung cancer RT subtypes reveals drug sensitivity."; RL Br. J. Cancer 109:1599-1608(2013). // RX PubMed=924690; DOI=10.1002/ijc.2910200505; RA Kerbel, Robert S. RA Pross, Hugh F. RA Leibovitz, Albert RT "Analysis of established human carcinoma cell lines for RT lymphoreticular-associated membrane receptors."; RL Int. J. Cancer 20:673-679(1977). // RX PubMed=833871; DOI=10.1093/jnci/58.2.209; RA Fogh, Jorgen RA Wright, William C. RA Loveless, James D. RT "Absence of HeLa cell contamination in 169 cell lines derived from RT human tumors."; RL J. Natl. Cancer Inst. 58:209-214(1977). // RX PubMed=16187286; DOI=10.1002/ijc.21491; RA Garnis, Cathie RA Lockwood, William W. RA Vucic, Emily RA Ge, Ying RA Girard, Luc RA Minna, John D. RA Gazdar, Adi F. RA Lam, Stephen RA MacAulay, Calum RA Lam, Wan L. RT "High resolution analysis of non-small cell lung cancer cell lines by RT whole genome tiling path array CGH."; RL Int. J. Cancer 118:1556-1564(2006). // RX PubMed=7459858; RA Rousset, Monique RA Zweibaum, Alain RA Fogh, Jorgen RT "Presence of glycogen and growth-related variations in 58 cultured RT human tumor cell lines of various tissue origins."; RL Cancer Res. 41:1165-1170(1981). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=7736387; DOI=10.1002/1097-0142(19950515)75:10<2442::AID-CNCR2820751009>3.0.CO;2-Q; RA Campling, Barbara G. RA Sarda, Inder R. RA Baer, Kathy A. RA Pang, Stephen C. RA Baker, Heather M. RA Lofters, Wycliffe S. RA Flynn, T. Geoffrey RT "Secretion of atrial natriuretic peptide and vasopressin by small cell RT lung cancer."; RL Cancer 75:2442-2451(1995). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=3518877; DOI=10.3109/07357908609038260; RA Fogh, Jorgen RT "Human tumor lines for cancer research."; RL Cancer Invest. 4:157-184(1986). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=327080; DOI=10.1093/jnci/59.1.221; RA Fogh, Jorgen RA Fogh, Jens M. RA Orfeo, Thomas RT "One hundred and twenty-seven cultured human tumor cell lines RT producing tumors in nude mice."; RL J. Natl. Cancer Inst. 59:221-226(1977). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). //