ID RXF 393L AC CVCL_1673 SY RXF393L; RXF-393 L; RXF-393; RXF 393; RXF.393; RXF393; RXF 393NL DR BTO; BTO_0004207 DR CLO; CLO_0009982 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-3610 DR cancercelllines; CVCL_1673 DR Cell_Model_Passport; SIDM00086 DR ChEMBL-Cells; CHEMBL3307734 DR ChEMBL-Targets; CHEMBL614886 DR Cosmic; 875872 DR Cosmic; 905978 DR Cosmic; 974306 DR Cosmic; 1175851 DR Cosmic; 1305376 DR Cosmic; 1312364 DR Cosmic; 1998471 DR Cosmic-CLP; 905978 DR DepMap; ACH-002195 DR EGA; EGAS00001000978 DR GDSC; 905978 DR GEO; GSM2100 DR GEO; GSM743484 DR GEO; GSM750839 DR GEO; GSM799375 DR GEO; GSM799438 DR GEO; GSM844678 DR GEO; GSM844679 DR GEO; GSM847111 DR GEO; GSM1153448 DR GEO; GSM1178577 DR GEO; GSM1178578 DR GEO; GSM1178579 DR GEO; GSM1181369 DR GEO; GSM1181370 DR GEO; GSM1670398 DR GEO; GSM2124681 DR IARC_TP53; 18073 DR LINCS_LDP; LCL-1770 DR NCI-DTP; RXF 393 DR PharmacoDB; RXF393_1338_2019 DR PRIDE; PXD003539 DR PRIDE; PXD005940 DR PRIDE; PXD005942 DR PRIDE; PXD005946 DR PRIDE; PXD030304 DR Progenetix; CVCL_1673 DR PubChem_Cell_line; CVCL_1673 DR SKY/M-FISH/CGH; 2800 DR Wikidata; Q54951507 RX PubMed=2041050; RX PubMed=9331090; RX PubMed=10700174; RX PubMed=15748285; RX PubMed=17088437; RX PubMed=18277095; RX PubMed=19372543; RX PubMed=20164919; RX PubMed=22068913; RX PubMed=22347499; RX PubMed=22384151; RX PubMed=22628656; RX PubMed=23856246; RX PubMed=23933261; RX PubMed=24279929; RX PubMed=24670534; RX PubMed=27377824; RX PubMed=27397505; RX PubMed=27807467; RX PubMed=28196595; RX PubMed=28489074; RX PubMed=30894373; RX PubMed=31733513; RX PubMed=35839778; RX PubMed=38861359; WW Info; MCLP; -; https://tcpaportal.org/mclp/ WW Info; NCI DTP; NCI-60; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm WW Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=39 WW Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/kidney-cancer-xenograft/rxf393-xenograft-model/ CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: MD Anderson Cell Lines Project. CC Part of: NCI-60 cancer cell line panel. CC Population: Caucasian. CC Doubling time: 62.9 hours (NCI-DTP=RXF 393). CC HLA typing: A*02,24; B*14:01,44; C*05,08:02; DPB1*01:01:01,04:01; DQB1*03:01:01,06:02; DRB1*11:01:01,15:01:01 (PubMed=15748285). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Homozygous (PubMed=9331090; PubMed=17088437; PubMed=18277095; Cosmic-CLP=905978; DepMap=ACH-002195). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Metabolomics. CC Omics: Phenotyping; Drug screening. CC Omics: Phenotyping; Fluorescent probe library screening. CC Omics: Proteomics. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform. CC Omics: Transcriptomics; Microarray. CC Omics: Variations; Array-based CGH. CC Omics: Variations; CNV analysis. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.51%; Native American=0.1%; East Asian, North=0%; East Asian, South=0.68%; South Asian=3.61%; European, North=57.95%; European, South=37.15% (PubMed=30894373). CC Misspelling: RXF393-RU; Cosmic=1175851. ST Source(s): Cosmic-CLP=905978; PubMed=19372543 ST Amelogenin: X ST CSF1PO: 10,12 ST D13S317: 9,12 ST D16S539: 11 ST D18S51: 16,18 ST D19S433: 13,14 ST D21S11: 28,33.2 ST D2S1338: 18 ST D3S1358: 15 ST D5S818: 12,13 ST D7S820: 11,12 ST D8S1179: 13 ST FGA: 24,27 ST TH01: 7,8 ST TPOX: 8,11 ST vWA: 16,17 DI NCIt; C9385; Renal cell carcinoma DI ORDO; Orphanet_217071; Renal cell carcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 54Y CA Cancer cell line DT Created: 04-04-12; Last updated: 27-11-25; Version: 43 // RX PubMed=9331090; RA O'Connor, Patrick M. RA Jackman, Joany RA Bae, Insoo RA Myers, Timothy Gene RA Fan, Sai-Jun RA Mutoh, Masato RA Scudiero, Dominic A. RA Monks, Anne RA Sausville, Edward A. RA Weinstein, John N. RA Friend, Stephen H. RA Fornace, Albert J. Jr. RA Kohn, Kurt W. RT "Characterization of the p53 tumor suppressor pathway in cell lines of RT the National Cancer Institute anticancer drug screen and correlations RT with the growth-inhibitory potency of 123 anticancer agents."; RL Cancer Res. 57:4285-4300(1997). // RX PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742; RA Adams, Sharon RA Robbins, Fu-Meei RA Chen, Deborah RA Wagage, Devika RA Holbeck, Susan L. RA Morse, Herbert Carpenter 3rd RA Stroncek, David RA Marincola, Francesco M. RT "HLA class I and II genotype of the NCI-60 cell lines."; RL J. Transl. Med. 3:11.1-11.8(2005). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=10700174; DOI=10.1038/73432; RA Ross, Douglas T. RA Scherf, Uwe RA Eisen, Michael Bruce RA Perou, Charles M. RA Rees, Christian RA Spellman, Paul T. RA Iyer, Vishwanath R. RA Jeffrey, Stefanie S. RA van de Rijn, Matt RA Waltham, Mark C. RA Pergamenschikov, Alexander RA Lee, Jeffrey C.F. RA Lashkari, Deval RA Shalon, Dari RA Myers, Timothy Gene RA Weinstein, John N. RA Botstein, David RA Brown, Patrick O'Reilly RT "Systematic variation in gene expression patterns in human cancer cell RT lines."; RL Nat. Genet. 24:227-235(2000). // RX PubMed=27807467; DOI=10.1186/s13100-016-0078-4; PMCID=PMC5087121; RA Zampella, John G. RA Rodic, Nemanja RA Yang, Wan Rou RA Huang, Cheng Ran Lisa RA Welch, Jane RA Gnanakkan, Veena P. RA Cornish, Toby Charles RA Boeke, Jef D. RA Burns, Kathleen H. RT "A map of mobile DNA insertions in the NCI-60 human cancer cell RT panel."; RL Mob. DNA 7:20.1-20.11(2016). // RX PubMed=28489074; DOI=10.1038/ncomms15165; PMCID=PMC5436135; RA Sinha, Rileen RA Winer, Andrew G. RA Chevinsky, Michael Stephen RA Jakubowski, Christopher RA Chen, Ying-Bei RA Dong, Yi-Yu RA Tickoo, Satish K. RA Reuter, Victor E. RA Russo, Paul RA Coleman, Jonathan A. RA Sander, Chris RA Hsieh, James J.-D. RA Hakimi, Abraham Ari RT "Analysis of renal cancer cell lines from two major resources enables RT genomics-guided cell line selection."; RL Nat. Commun. 8:15165.1-15165.10(2017). // RX PubMed=24670534; DOI=10.1371/journal.pone.0092047; PMCID=PMC3966786; RA Varma, Sudhir RA Pommier, Yves RA Sunshine, Margot RA Weinstein, John N. RA Reinhold, William C. RT "High resolution copy number variation data in the NCI-60 cancer cell RT lines from whole genome microarrays accessible through CellMiner."; RL PLoS ONE 9:e92047.1-e92047.15(2014). // RX PubMed=2041050; DOI=10.1093/jnci/83.11.757; RA Monks, Anne RA Scudiero, Dominic A. RA Skehan, Philip RA Shoemaker, Robert H. RA Paull, Kenneth D. RA Vistica, David T. RA Hose, Curtis D. RA Langley, John RA Cronise, Paul RA Vaigro-Wolff, Anne RA Gray-Goodrich, Marcia RA Campbell, Hugh RA Mayo, Joseph G. RA Boyd, Michael R. RT "Feasibility of a high-flux anticancer drug screen using a diverse RT panel of cultured human tumor cell lines."; RL J. Natl. Cancer Inst. 83:757-766(1991). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832; RA Ikediobi, Ogechi N. RA Davies, Helen R. RA Bignell, Graham Robert RA Edkins, Sarah RA Stevens, Claire RA O'Meara, Sarah RA Santarius, Thomas RA Avis, Tim RA Barthorpe, Syd RA Brackenbury, Lisa RA Buck, Gemma RA Butler, Adam P. RA Clements, Jody RA Cole, Jennifer RA Dicks, Ed RA Forbes, Simon RA Gray, Kristian RA Halliday, Kelly RA Harrison, Rachel RA Hills, Katy RA Hinton, Jonathan RA Hunter, Chris RA Jenkinson, Andy RA Jones, David RA Kosmidou, Vivian RA Lugg, Richard RA Menzies, Andrew RA Mironenko, Tatiana RA Parker, Adrian RA Perry, Janet RA Raine, Keiran Martin RA Richardson, David RA Shepherd, Rebecca RA Small, Alex RA Smith, Raffaella RA Solomon, Helen RA Stephens, Philip J. RA Teague, Jon W. RA Tofts, Calli RA Varian, Jennifer RA Webb, Tony RA West, Sofie RA Widaa, Sara RA Yates, Andy RA Reinhold, William C. RA Weinstein, John N. RA Stratton, Michael Rudolf RA Futreal, P. Andrew RA Wooster, Richard RT "Mutation analysis of 24 known cancer genes in the NCI-60 cell line RT set."; RL Mol. Cancer Ther. 5:2606-2612(2006). // RX PubMed=27377824; DOI=10.1038/sdata.2016.52; PMCID=PMC4932877; RA Mestdagh, Pieter RA Lefever, Steve RA Volders, Pieter-Jan RA Derveaux, Stefaan RA Hellemans, Jan RA Vandesompele, Jo RT "Long non-coding RNA expression profiling in the NCI60 cancer cell RT line panel using high-throughput RT-qPCR."; RL Sci. Data 3:160052.1-160052.6(2016). // RX PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018; RA Moghaddas Gholami, Amin RA Hahne, Hannes RA Wu, Zhi-Xiang RA Auer, Florian Johann RA Meng, Chen RA Wilhelm, Mathias RA Kuster, Bernhard RT "Global proteome analysis of the NCI-60 cell line panel."; RL Cell Rep. 4:609-620(2013). // RX PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921; PMCID=PMC4020356; RA Lorenzi, Philip L. RA Reinhold, William C. RA Varma, Sudhir RA Hutchinson, Amy A. RA Pommier, Yves RA Chanock, Stephen Jacob RA Weinstein, John N. RT "DNA fingerprinting of the NCI-60 cell line panel."; RL Mol. Cancer Ther. 8:713-724(2009). // RX PubMed=22347499; DOI=10.1371/journal.pone.0031628; PMCID=PMC3276511; RA Ruan, Xiao-Yang RA Kocher, Jean-Pierre A. RA Pommier, Yves RA Liu, Hong-Fang RA Reinhold, William C. RT "Mass homozygotes accumulation in the NCI-60 cancer cell lines as RT compared to HapMap trios, and relation to fragile site location."; RL PLoS ONE 7:e31628.1-e31628.9(2012). // RX PubMed=38861359; DOI=10.1158/0008-5472.CAN-23-3031; PMCID=PMC11292194; RA Kunkel, Mark W. RA Coussens, Nathan P. RA Morris, Joel RA Taylor, Ronald C. RA Dexheimer, Thomas S. RA Jones, Eric M. RA Doroshow, James H. RA Teicher, Beverly A. RT "HTS384 NCI60: the next phase of the NCI60 screen."; RL Cancer Res. 84:2403-2416(2024). // RX PubMed=31733513; DOI=10.1016/j.isci.2019.10.059; PMCID=PMC6889472; RA Guo, Tian-Nan RA Luna, Augustin RA Rajapakse, Vinodh N. RA Koh, Gene Ching-Chiek RA Wu, Zhi-Cheng RA Liu, Wei RA Sun, Yao-Ting RA Gao, Huan-Huan RA Menden, Michael Patrick RA Xu, Chao RA Calzone, Laurence RA Martignetti, Loredana RA Auwerx, Chiara RA Buljan, Marija RA Banaei-Esfahani, Amir RA Ori, Alessandro RA Iskar, Murat RA Gillet, Ludovic C. RA Bi, Ran RA Zhang, Jiang-Nan RA Zhang, Huan-Huan RA Yu, Chen-Huan RA Zhong, Qing RA Varma, Sudhir RA Schmitt, Uwe RA Qiu, Peng RA Zhang, Qiu-Shi RA Zhu, Yi RA Wild, Peter Johannes RA Garnett, Mathew J. RA Bork, Peer RA Beck, Martin RA Liu, Ke-Xin RA Saez-Rodriguez, Julio RA Elloumi, Fathi RA Reinhold, William C. RA Sander, Chris RA Pommier, Yves RA Aebersold, Ruedi RT "Quantitative proteome landscape of the NCI-60 cancer cell lines."; RL iScience 21:664-680(2019). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=22068913; DOI=10.1073/pnas.1111840108; PMCID=PMC3219108; RA Gillet, Jean-Pierre RA Calcagno, Anna Maria RA Varma, Sudhir RA Marino, Miguel RA Green, Lisa J. RA Vora, Meena I. RA Patel, Chirayu RA Orina, Josiah N. RA Eliseeva, Tatiana A. RA Singal, Vineet RA Padmanabhan, Raji RA Davidson, Ben RA Ganapathi, Ram RA Sood, Anil K. RA Rueda, Bo R. RA Ambudkar, Suresh V. RA Gottesman, Michael Marc RT "Redefining the relevance of established cancer cell lines to the RT study of mechanisms of clinical anti-cancer drug resistance."; RL Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011). // RX PubMed=24279929; DOI=10.1186/2049-3002-1-20; PMCID=PMC4178206; RA Dolfi, Sonia C. RA Chan, Leo Li-Ying RA Qiu, Jean RA Tedeschi, Philip M. RA Bertino, Joseph Rocco RA Hirshfield, Kim Marie RA Oltvai, Zoltan Nagy RA Vazquez, Alexei RT "The metabolic demands of cancer cells are coupled to their size and RT protein synthesis rates."; RL Cancer Metab. 1:20.1-20.13(2013). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=22384151; DOI=10.1371/journal.pone.0032096; PMCID=PMC3285665; RA Lee, Jun-Seok RA Kim, Yun Kyung RA Kim, Han Jo RA Hajar, Siti RA Tan, Yee Ling RA Kang, Nam-Young RA Ng, Shin Hui RA Yoon, Chang No RA Chang, Young-Tae RT "Identification of cancer cell-line origins using fluorescence RT image-based phenomic screening."; RL PLoS ONE 7:e32096.1-e32096.8(2012). // RX PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342; PMCID=PMC4893961; RA Abaan, Ogan Demir RA Polley, Eric C. RA Davis, Sean R. RA Zhu, Yue-Lin J. RA Bilke, Sven RA Walker, Robert L. RA Pineda, Marbin A. RA Gindin, Yevgeniy RA Jiang, Yuan RA Reinhold, William C. RA Holbeck, Susan L. RA Simon, Richard M. RA Doroshow, James H. RA Pommier, Yves RA Meltzer, Paul S. RT "The exomes of the NCI-60 panel: a genomic resource for cancer biology RT and systems pharmacology."; RL Cancer Res. 73:4372-4382(2013). // RX PubMed=22628656; DOI=10.1126/science.1218595; PMCID=PMC3526189; RA Jain, Mohit RA Nilsson, Roland RA Sharma, Sonia RA Madhusudhan, Nikhil RA Kitami, Toshimori RA Souza, Amanda L. RA Kafri, Ran RA Kirschner, Marc Wallace RA Clish, Clary B. RA Mootha, Vamsi Krishna RT "Metabolite profiling identifies a key role for glycine in rapid RT cancer cell proliferation."; RL Science 336:1040-1044(2012). // RX PubMed=18277095; DOI=10.4161/cbt.7.5.5712; RA Berglind, Hanna RA Pawitan, Yudi RA Kato, Shunsuke RA Ishioka, Chikashi RA Soussi, Thierry RT "Analysis of p53 mutation status in human cancer cell lines: a RT paradigm for cell line cross-contamination."; RL Cancer Biol. Ther. 7:699-708(2008). //