ID RCM-1 [Human rectal adenocarcinoma] AC CVCL_1648 SY RCM1 DR CLO; CLO_0009972 DR EFO; EFO_0006476 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 996 DR BioSample; SAMN03472886 DR BioSample; SAMN10988165 DR cancercelllines; CVCL_1648 DR Cell_Model_Passport; SIDM00359 DR ChEMBL-Cells; CHEMBL3308125 DR ChEMBL-Targets; CHEMBL1075562 DR ColonAtlas; RCM1 DR Cosmic; 873704 DR Cosmic; 909263 DR Cosmic; 1122329 DR Cosmic; 1184088 DR Cosmic; 1187314 DR Cosmic; 1995616 DR Cosmic-CLP; 909263 DR DepMap; ACH-000565 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR EGA; EGAS00001002554 DR GDSC; 909263 DR GEO; GSM827229 DR GEO; GSM887526 DR GEO; GSM888608 DR GEO; GSM1374846 DR GEO; GSM1448098 DR GEO; GSM1670367 DR IARC_TP53; 21282 DR JCRB; JCRB0256 DR LiGeA; CCLE_779 DR LINCS_LDP; LCL-1290 DR PharmacoDB; RCM1_1295_2019 DR PRIDE; PXD005235 DR PRIDE; PXD005354 DR PRIDE; PXD005355 DR PRIDE; PXD030304 DR Progenetix; CVCL_1648 DR PubChem_Cell_line; CVCL_1648 DR Wikidata; Q54949516 RX PubMed=2570482; RX PubMed=3198327; RX PubMed=8348978; RX PubMed=9247707; RX PubMed=9290701; RX PubMed=16418264; RX PubMed=18258742; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=20606684; RX PubMed=22460905; RX PubMed=23272949; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25926053; RX PubMed=26589293; RX PubMed=27397505; RX PubMed=28854368; RX PubMed=29101300; RX PubMed=29444439; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=35839778; CC Part of: AstraZeneca Colorectal cell line (AZCL) panel. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: NCI RAS program mutant KRAS cell line panel. CC Population: Japanese. CC Doubling time: 71.4 hours (PubMed=2570482). CC HLA typing: A*24:02,24:02; B*51:01,54:01; C*01:02,14:02; DQA1*01:02,05:02; DQB1*05:01,05:01; DRB1*01:01,12:01 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (PubMed=25926053; Sanger). CC Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Arg216Ter (c.646C>T); ClinVar=VCV000127312; Zygosity=Heterozygous (Cosmic-CLP=909263; DepMap=ACH-000565). CC Sequence variation: Mutation; HGNC; HGNC:3373; EP300; Simple; p.Gln1740Ter (c.5218C>T); Zygosity=Heterozygous (Cosmic-CLP=909263; DepMap=ACH-000565). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (Cosmic-CLP=909263; DepMap=ACH-000565). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Homozygous (PubMed=16418264; Cosmic-CLP=909263; DepMap=ACH-000565). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Proteomics. CC Omics: Proteomics; PTM; Phosphorylation; Quantitative. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.97%; Native American=0%; East Asian, North=75.44%; East Asian, South=22.81%; South Asian=0.01%; European, North=0%; European, South=0.77% (PubMed=30894373). CC Derived from site: In situ; Rectum; UBERON=UBERON_0001052. ST Source(s): Cosmic-CLP=909263; JCRB=JCRB0256; PubMed=25877200; PubMed=25926053 ST Amelogenin: X ST CSF1PO: 10,12 ST D13S317: 10,12 ST D16S539: 9,11,12 (Cosmic-CLP=909263) ST D16S539: 11,12 (JCRB=JCRB0256; PubMed=25877200; PubMed=25926053) ST D18S51: 15 ST D21S11: 29 ST D3S1358: 16 ST D5S818: 11 (PubMed=25926053) ST D5S818: 11,12 (Cosmic-CLP=909263; JCRB=JCRB0256; PubMed=25877200) ST D7S820: 11,12 ST D8S1179: 13 ST FGA: 20,22 ST Penta D: 9 ST TH01: 9 ST TPOX: 8,11 ST vWA: 20 DI NCIt; C9383; Rectal adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 73Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 41 // RX PubMed=20606684; DOI=10.1038/sj.bjc.6605780; PMCID=PMC2920028; RA Bracht, Karin RA Nicholls, Angela M. RA Liu, Ying RA Bodmer, Walter Fred RT "5-fluorouracil response in a large panel of colorectal cancer cell RT lines is associated with mismatch repair deficiency."; RL Br. J. 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RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=16418264; DOI=10.1073/pnas.0510146103; PMCID=PMC1327731; RA Liu, Ying RA Bodmer, Walter Fred RT "Analysis of p53 mutations and their expression in 56 colorectal RT cancer cell lines."; RL Proc. Natl. Acad. Sci. U.S.A. 103:976-981(2006). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. 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RT "Genomic determinants of protein abundance variation in colorectal RT cancer cells."; RL Cell Rep. 20:2201-2214(2017). // RX PubMed=25926053; DOI=10.1038/ncomms8002; RA Medico, Enzo RA Russo, Mariangela RA Picco, Gabriele RA Cancelliere, Carlotta RA Valtorta, Emanuele RA Corti, Giorgio RA Buscarino, Michela RA Isella, Claudio RA Lamba, Simona RA Martinoglio, Barbara RA Veronese, Silvio RA Siena, Salvatore RA Sartore-Bianchi, Andrea RA Beccuti, Marco RA Mottolese, Marcella RA Linnebacher, Michael RA Cordero, Francesca RA Di Nicolantonio, Federica RA Bardelli, Alberto RT "The molecular landscape of colorectal cancer cell lines unveils RT clinically actionable kinase targets."; RL Nat. Commun. 6:7002.1-7002.10(2015). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. 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RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. 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