ID Panc 08.13 AC CVCL_1638 AS CVCL_H599 SY Panc 8.13; Panc-08.13; PANC-08-13; Panc_08_13; Panc08.13; Panc8.13; Panc-8_13; Panc-813; PANC 813; Panc813; PANC813; PANC0813; Panc0813; Pa14C; PL9; PL-9 DR CLO; CLO_0008379 DR EFO; EFO_0006470 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR ATCC; CRL-2551 DR BioGRID_ORCS_Cell_line; 189 DR BioSample; SAMN03472947 DR BioSample; SAMN10988145 DR cancercelllines; CVCL_1638 DR Cell_Model_Passport; SIDM01136 DR ChEMBL-Cells; CHEMBL3308777 DR ChEMBL-Targets; CHEMBL1075558 DR Cosmic; 925347 DR Cosmic; 949526 DR Cosmic; 1198215 DR Cosmic; 1198221 DR Cosmic; 1473126 DR Cosmic; 1509858 DR Cosmic; 2434104 DR Cosmic-CLP; 925347 DR DepMap; ACH-000417 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 925347 DR GEO; GSM206531 DR GEO; GSM621905 DR GEO; GSM784709 DR GEO; GSM827278 DR GEO; GSM887499 DR GEO; GSM888581 DR GEO; GSM1024410 DR GEO; GSM1374813 DR GEO; GSM1670334 DR LiGeA; CCLE_501 DR LINCS_LDP; LCL-1742 DR PharmacoDB; Panc08_13_1244_2019 DR PRIDE; PXD003198 DR PRIDE; PXD030304 DR Progenetix; CVCL_1638 DR PubChem_Cell_line; CVCL_1638 DR Wikidata; Q54937528 RX PubMed=9612602; RX PubMed=14695172; RX PubMed=16912165; RX PubMed=18000365; RX PubMed=20164919; RX PubMed=20215515; RX PubMed=22460905; RX PubMed=22585861; RX PubMed=22753594; RX PubMed=25167228; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25984343; RX PubMed=26589293; RX PubMed=27259358; RX PubMed=27397505; RX PubMed=29444439; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=35839778; CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: NCI RAS program mutant KRAS cell line panel. CC From: Johns Hopkins University School of Medicine; Baltimore; USA. CC Population: Caucasian. CC Doubling time: 20.0 hours (PubMed=9612602); 117 hours (PubMed=25984343). CC HLA typing: A*02:01,02:01; B*07:02,15:40; C*02:02,05:01 (PubMed=26589293). CC Microsatellite instability: Instable (MSI-low) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Homozygous (PubMed=9612602; ATCC=CRL-2551). CC Sequence variation: Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Cys123Metfs*2 (c.366dupA) (c.366_367insA); Zygosity=Homozygous (ATCC=CRL-2551). CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Phenotyping; shRNA library screening. CC Omics: Proteomics. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=2.26%; Native American=0.57%; East Asian, North=2.49%; East Asian, South=0%; South Asian=0%; European, North=62.31%; European, South=32.37% (PubMed=30894373). CC Derived from site: In situ; Pancreas; UBERON=UBERON_0001264. ST Source(s): ATCC=CRL-2551; Cosmic-CLP=925347; PubMed=25877200 ST Amelogenin: X ST CSF1PO: 11 ST D13S317: 13 ST D16S539: 13 ST D18S51: 19 ST D19S433: 13 ST D21S11: 32.2 ST D2S1338: 17,18 ST D3S1358: 16 ST D5S818: 13,14 ST D7S820: 11 ST D8S1179: 10,14 ST FGA: 21,23 ST Penta D: 10 ST Penta E: 5,16,17 ST TH01: 6,9.3 ST TPOX: 8,12 ST vWA: 18 DI NCIt; C9120; Pancreatic ductal adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Male AG 85Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 42 // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=25167228; DOI=10.1038/bjc.2014.475; PMCID=PMC4453732; RA Hamidi, Habib RA Lu, Ming RA Chau, Kevin RA Anderson, Lee RA Fejzo, Marlena Schoenberg RA Ginther, Charles RA Linnartz, Ronald RA Zubel, Angela RA Slamon, Dennis Joseph RA Finn, Richard Samuel RT "KRAS mutational subtype and copy number predict in vitro response of RT human pancreatic cancer cell lines to MEK inhibition."; RL Br. J. Cancer 111:1788-1801(2014). // RX PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396; RA Marcotte, Richard RA Brown, Kevin R. RA Suarez Saiz, Fernando Jose RA Sayad, Azin RA Karamboulas, Konstantina RA Krzyzanowski, Paul M. RA Sircoulomb, Fabrice RA Medrano, Mauricio RA Fedyshyn, Yaroslav RA Koh, Judice Lie-Yong RA van Dyk, Dewald RA Fedyshyn, Bohdana RA Luhova, Marianna RA Brito, Glauber C. RA Vizeacoumar, Franco J. RA Vizeacoumar, Frederick S. RA Datti, Alessandro RA Kasimer, Dahlia RA Buzina, Alla RA Mero, Patricia RA Misquitta, Christine RA Normand, Josee RA Haider, Maliha RA Ketela, Troy RA Wrana, Jeffrey L. RA Rottapel, Robert RA Neel, Benjamin G. RA Moffat, Jason RT "Essential gene profiles in breast, pancreatic, and ovarian cancer RT cells."; RL Cancer Discov. 2:172-189(2012). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=18000365; DOI=10.1159/000108295; RA Griffin, Constance A. RA Morsberger, Laura A. RA Hawkins, Anita L. RA Haddadin, Mary H. RA Patel, Ankita S. RA Ried, Thomas RA Schrock, Evelin RA Perlman, Elizabeth J. RA Jaffee, Elizabeth Marion RT "Molecular cytogenetic characterization of pancreas cancer cell lines RT reveals high complexity chromosomal alterations."; RL Cytogenet. Genome Res. 118:148-156(2007). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=9612602; RA Jaffee, Elizabeth Marion RA Schutte, Mieke RA Gossett, Jeanette RA Morsberger, Laura A. RA Adler, Adam J. RA Thomas, Matthew RA Greten, Tim F. RA Hruban, Ralph H. RA Yeo, Charles J. RA Griffin, Constance A. RT "Development and characterization of a cytokine-secreting pancreatic RT adenocarcinoma vaccine from primary tumors for use in clinical RT trials."; RL Cancer J. Sci. Am. 4:194-203(1998). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662; RA Rothenberg, S. Michael RA Mohapatra, Gayatry RA Rivera, Miguel N. RA Winokur, Daniel RA Greninger, Patricia RA Nitta, Mai RA Sadow, Peter M. RA Sooriyakumar, Gaya RA Brannigan, Brian W. RA Ulman, Matthew J. RA Perera, Rushika M. RA Wang, Rui RA Tam, Angela RA Ma, Xiao-Jun RA Erlander, Mark RA Sgroi, Dennis C. RA Rocco, James W. RA Lingen, Mark W. RA Cohen, Ezra E.W. RA Louis, David Neil RA Settleman, Jeffrey RA Haber, Daniel Arie RT "A genome-wide screen for microdeletions reveals disruption of RT polarity complex genes in diverse human cancers."; RL Cancer Res. 70:2158-2164(2010). // RX PubMed=22753594; DOI=10.1158/1078-0432.CCR-12-0827; PMCID=PMC3513499; RA Cui, Yun-Feng RA Brosnan-Cashman, Jacqueline A. RA Blackford, Amanda L. RA Sur, Surojit RA Hruban, Ralph H. RA Kinzler, Kenneth Wayne RA Vogelstein, Bert RA Maitra, Anirban RA Diaz, Luis Alberto Jr. RA Iacobuzio-Donahue, Christine A. RA Eshleman, James Richard RT "Genetically defined subsets of human pancreatic cancer show unique in RT vitro chemosensitivity."; RL Clin. Cancer Res. 18:6519-6530(2012). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura E. RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=27259358; DOI=10.1074/mcp.M116.058313; PMCID=PMC4974343; RA Humphrey, Emily S. RA Su, Shih-Ping RA Nagrial, Adnan M. RA Hochgrafe, Falko RA Pajic, Marina RA Lehrbach, Gillian M. RA Parton, Robert G. RA Yap, Alpha S. RA Horvath, Lisa G. RA Chang, David K. RA Biankin, Andrew Victor RA Wu, Jian-Min RA Daly, Roger J. RT "Resolution of novel pancreatic ductal adenocarcinoma subtypes by RT global phosphotyrosine profiling."; RL Mol. Cell. Proteomics 15:2671-2685(2016). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652; RA Cowley, Glenn S. RA Weir, Barbara A. RA Vazquez, Francisca RA Tamayo, Pablo RA Scott, Justine A. RA Rusin, Scott RA East-Seletsky, Alexandra RA Ali, Levi D. RA Gerath, William F.J. RA Pantel, Sarah E. RA Lizotte, Patrick Hall RA Jiang, Guo-Zhi RA Hsiao, Jessica RA Tsherniak, Aviad RA Dwinell, Elizabeth RA Aoyama, Simon RA Okamoto, Michael RA Harrington, William RA Gelfand, Ellen T. RA Green, Thomas M. RA Tomko, Mark J. RA Gopal, Shuba RA Wong, Terence C. RA Li, Hu-Bo RA Howell, Sara RA Stransky, Nicolas RA Liefeld, Ted RA Jang, Dongkeun RA Bistline, Jonathan RA Meyers, Barbara Hill RA Armstrong, Scott Allen RA Anderson, Kenneth Carl RA Stegmaier, Kimberly RA Reich, Michael RA Pellman, David RA Boehm, Jesse S. RA Mesirov, Jill P. RA Golub, Todd Robert RA Root, David E. RA Hahn, William Chun RT "Parallel genome-scale loss of function screens in 216 cancer cell RT lines for the identification of context-specific genetic RT dependencies."; RL Sci. Data 1:140035.1-140035.12(2014). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=16912165; DOI=10.1158/0008-5472.CAN-06-0721; RA Calhoun, Eric S. RA Hucl, Tomas RA Gallmeier, Eike RA West, Kristen M. RA Arking, Dan E. RA Maitra, Anirban RA Iacobuzio-Donahue, Christine A. RA Chakravarti, Aravinda RA Hruban, Ralph H. RA Kern, Scott E. RT "Identifying allelic loss and homozygous deletions in pancreatic RT cancer without matched normals using high-density single-nucleotide RT polymorphism arrays."; RL Cancer Res. 66:7920-7928(2006). // RX PubMed=29444439; DOI=10.1016/j.celrep.2018.01.051; PMCID=PMC6343826; RA Yuan, Tina L. RA Amzallag, Arnaud RA Bagni, Rachel RA Yi, Ming RA Afghani, Shervin RA Burgan, William RA Fer, Nicole RA Strathern, Leslie A. RA Powell, Katie RA Smith, Brian RA Waters, Andrew Michael RA Drubin, David Alan RA Thomson, Ty RA Liao, Rosy RA Greninger, Patricia RA Stein, Giovanna T. RA Murchie, Ellen RA Cortez, Eliane RA Egan, Regina K. RA Procter, Lauren RA Bess, Matthew RA Cheng, Kwong Tai RA Lee, Chih-Shia RA Lee, Liam Changwoo RA Fellmann, Christof RA Stephens, Robert RA Luo, Ji RA Lowe, Scott William RA Benes, Cyril Henri RA McCormick, Frank RT "Differential effector engagement by oncogenic KRAS."; RL Cell Rep. 22:1889-1902(2018). // RX PubMed=14695172; RA Iacobuzio-Donahue, Christine A. RA Ashfaq, Raheela RA Maitra, Anirban RA Adsay, Nazmi Volkan RA Shen-Ong, Grace L.-C. RA Berg, Karin RA Hollingsworth, Michael Anthony RA Cameron, John Lemuel RA Yeo, Charles J. RA Kern, Scott E. RA Goggins, Michael Gilbert RA Hruban, Ralph H. RT "Highly expressed genes in pancreatic ductal adenocarcinomas: a RT comprehensive characterization and comparison of the transcription RT profiles obtained from three major technologies."; RL Cancer Res. 63:8614-8622(2003). //