ID OVCAR-8 AC CVCL_1629 SY OVCAR 8; NIH:OVCAR-8; OVCAR8; Ovcar8; OVCAR.8; OVCA8 DR BTO; BTO_0003054 DR EFO; EFO_0005444 DR ArrayExpress; E-MTAB-783 DR ArrayExpress; E-MTAB-2706 DR ArrayExpress; E-MTAB-2770 DR ArrayExpress; E-MTAB-3610 DR BioGRID_ORCS_Cell_line; 392 DR BioSample; SAMN03472794 DR BioSample; SAMN10988023 DR cancercelllines; CVCL_1629 DR Cell_Model_Passport; SIDM00090 DR ChEMBL-Cells; CHEMBL3307975 DR ChEMBL-Targets; CHEMBL612555 DR Cosmic; 688106 DR Cosmic; 875862 DR Cosmic; 905991 DR Cosmic; 974298 DR Cosmic; 1044242 DR Cosmic; 1092626 DR Cosmic; 1093555 DR Cosmic; 1305315 DR Cosmic; 1312357 DR Cosmic; 1436036 DR Cosmic; 1523764 DR Cosmic; 1526923 DR Cosmic; 1998468 DR Cosmic; 2186582 DR Cosmic-CLP; 905991 DR DepMap; ACH-000696 DR EGA; EGAS00001000610 DR EGA; EGAS00001000978 DR GDSC; 905991 DR GEO; GSM2117 DR GEO; GSM50222 DR GEO; GSM50286 DR GEO; GSM185143 DR GEO; GSM185144 DR GEO; GSM322534 DR GEO; GSM322535 DR GEO; GSM322536 DR GEO; GSM459646 DR GEO; GSM459647 DR GEO; GSM711710 DR GEO; GSM743477 DR GEO; GSM743495 DR GEO; GSM750819 DR GEO; GSM750831 DR GEO; GSM784574 DR GEO; GSM799366 DR GEO; GSM799429 DR GEO; GSM844672 DR GEO; GSM844673 DR GEO; GSM847109 DR GEO; GSM851937 DR GEO; GSM887485 DR GEO; GSM888566 DR GEO; GSM1153438 DR GEO; GSM1181299 DR GEO; GSM1181339 DR GEO; GSM1340588 DR GEO; GSM1341132 DR GEO; GSM1374803 DR GEO; GSM1670320 DR GEO; GSM2124679 DR GEO; GSM2474994 DR GEO; GSM2748150 DR GEO; GSM2748151 DR GEO; GSM2748152 DR GEO; GSM2748153 DR GEO; GSM2748154 DR GEO; GSM2748155 DR GEO; GSM3161724 DR GEO; GSM3161725 DR IARC_TP53; 18079 DR IARC_TP53; 21121 DR LiGeA; CCLE_464 DR NCI-DTP; OVCAR-8 DR PharmacoDB; OVCAR8_1220_2019 DR PRIDE; PXD003539 DR PRIDE; PXD005942 DR PRIDE; PXD005946 DR PRIDE; PXD030304 DR Progenetix; CVCL_1629 DR PubChem_Cell_line; CVCL_1629 DR SKY/M-FISH/CGH; 1437 DR Wikidata; Q54937014 RX DOI=10.4172/2157-7145.S2-005; RX PubMed=1348364; RX PubMed=2041050; RX PubMed=2307530; RX PubMed=3335022; RX PubMed=7718330; RX PubMed=9041185; RX PubMed=9331090; RX PubMed=10700174; RX PubMed=12417041; RX PubMed=12960427; RX PubMed=15748285; RX PubMed=17088437; RX PubMed=19372543; RX PubMed=20164919; RX PubMed=20204287; RX PubMed=21912889; RX PubMed=22068913; RX PubMed=22336246; RX PubMed=22347499; RX PubMed=22384151; RX PubMed=22460905; RX PubMed=22585861; RX PubMed=22628656; RX PubMed=22710073; RX PubMed=23415752; RX PubMed=23839242; RX PubMed=23856246; RX PubMed=23933261; RX PubMed=24023729; RX PubMed=24279929; RX PubMed=24670534; RX PubMed=25485619; RX PubMed=25877200; RX PubMed=25984343; RX PubMed=26589293; RX PubMed=27235858; RX PubMed=27377824; RX PubMed=27397505; RX PubMed=27807467; RX PubMed=28196595; RX PubMed=28273451; RX PubMed=30485824; RX PubMed=30894373; RX PubMed=30971826; RX PubMed=31068700; RX PubMed=31733513; RX PubMed=31978347; RX PubMed=35839778; RX PubMed=38861359; WW Info; MCLP; -; https://tcpaportal.org/mclp/ WW Info; NCI DTP; NCI-60; https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm WW Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=25 CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: COSMIC cell lines project. CC Part of: JFCR39 cancer cell line panel. CC Part of: KuDOS 95 cell line panel. CC Part of: MD Anderson Cell Lines Project. CC Part of: NCI-60 cancer cell line panel. CC Population: Caucasian. CC Doubling time: 24 hours (PubMed=7718330); 25 hours (PubMed=25984343); 26.1 hours (NCI-DTP=OVCAR-8); 31.93 hours (JWGray panel). CC HLA typing: A*01:01:01,25:01; B*57:01:01; C*06:02; DPB1*02:01:02,13:01; DQB1*03:03:02,06:02; DRB1*07:01,15:01:01 (PubMed=15748285). CC HLA typing: A*01:01,25:01; B*57:01,57:01; C*06:02,06:02 (PubMed=26589293). CC Microsatellite instability: Stable (MSS) (Sanger). CC Sequence variation: Mutation; HGNC; HGNC:2514; CTNNB1; Simple; p.Gln26Arg (c.77A>G); Zygosity=Heterozygous (PubMed=28273451; Cosmic-CLP=905991). CC Sequence variation: Mutation; HGNC; HGNC:3430; ERBB2; Simple; p.Gly776Val (c.2327G>T); ClinVar=VCV000163410; Zygosity=Heterozygous (PubMed=17088437). CC Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Pro121His (c.362C>A); Zygosity=Heterozygous (PubMed=28273451; Cosmic-CLP=905991). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.376-1G>A (p.Tyr126_Lys132del, c.376_396del21); ClinVar=VCV000481003; Zygosity=Homozygous; Note=Splice acceptor mutation (PubMed=9331090; PubMed=20204287; PubMed=21912889; PubMed=28273451; Cosmic-CLP=905991). CC Omics: Genomics; Chromatin accessibility; ATAC-seq. CC Omics: Genomics; DNA methylation analysis. CC Omics: Genomics; Whole exome sequencing. CC Omics: Genomics; Whole genome sequencing. CC Omics: Metabolomics. CC Omics: Phenotyping; CRISPR screening. CC Omics: Phenotyping; Drug screening. CC Omics: Phenotyping; Fluorescent probe library screening. CC Omics: Phenotyping; shRNA library screening. CC Omics: Proteomics. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Proteomics; Quantitative. CC Omics: Transcriptomics; lncRNA profiling; RT-qPCR platform. CC Omics: Transcriptomics; Microarray. CC Omics: Transcriptomics; RNAseq. CC Omics: Variations; Array-based CGH. CC Omics: Variations; CNV analysis. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0.22%; Native American=0%; East Asian, North=3.41%; East Asian, South=0%; South Asian=0.98%; European, North=60.74%; European, South=34.66% (PubMed=30894373). CC Misspelling: OVACAR8; Cosmic=1526923. CC Misspelling: OVOCAR-8; Note=Occasionally. CC Misspelling: OVOCAR8; Note=Occasionally. ST Source(s): Cosmic-CLP=905991; DOI=10.4172/2157-7145.S2-005; PubMed=19372543; PubMed=25877200; PubMed=30485824; Technion Genomics Center ST Amelogenin: X ST CSF1PO: 11 ST D10S1248: 14 ST D12S391: 15,18 ST D13S317: 12 ST D16S539: 13 ST D18S51: 14 ST D19S433: 14,16 ST D1S1656: 19.3 ST D21S11: 28 ST D22S1045: 11 ST D2S1338: 19,23 ST D2S441: 10,11 ST D3S1358: 16,18 ST D5S818: 12 ST D7S820: 12 ST D8S1179: 10 ST FGA: 20 ST Penta D: 12 ST Penta E: 10 ST TH01: 7 ST TPOX: 8 ST vWA: 16,17 DI NCIt; C105555; High grade ovarian serous adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) SX Female AG 64Y CA Cancer cell line DT Created: 04-04-12; Last updated: 27-11-25; Version: 48 CH CVCL_B0CC ! ART [Human OVCAR-8 contaminated cell line] CH CVCL_ZZ16 ! MCF-7 TH CH CVCL_1452 ! NCI-ADR-RES CH CVCL_D703 ! OV-1847 CH CVCL_IM65 ! OVCAR-8 RIA CH CVCL_IM66 ! OVCAR-8 RIIB // RX PubMed=22347499; DOI=10.1371/journal.pone.0031628; PMCID=PMC3276511; RA Ruan, Xiao-Yang RA Kocher, Jean-Pierre A. RA Pommier, Yves RA Liu, Hong-Fang RA Reinhold, William C. RT "Mass homozygotes accumulation in the NCI-60 cancer cell lines as RT compared to HapMap trios, and relation to fragile site location."; RL PLoS ONE 7:e31628.1-e31628.9(2012). // RX PubMed=15748285; DOI=10.1186/1479-5876-3-11; PMCID=PMC555742; RA Adams, Sharon RA Robbins, Fu-Meei RA Chen, Deborah RA Wagage, Devika RA Holbeck, Susan L. RA Morse, Herbert Carpenter 3rd RA Stroncek, David RA Marincola, Francesco M. RT "HLA class I and II genotype of the NCI-60 cell lines."; RL J. Transl. Med. 3:11.1-11.8(2005). // RX PubMed=17088437; DOI=10.1158/1535-7163.MCT-06-0433; PMCID=PMC2705832; RA Ikediobi, Ogechi N. RA Davies, Helen R. RA Bignell, Graham Robert RA Edkins, Sarah RA Stevens, Claire RA O'Meara, Sarah RA Santarius, Thomas RA Avis, Tim RA Barthorpe, Syd RA Brackenbury, Lisa RA Buck, Gemma RA Butler, Adam P. RA Clements, Jody RA Cole, Jennifer RA Dicks, Ed RA Forbes, Simon RA Gray, Kristian RA Halliday, Kelly RA Harrison, Rachel RA Hills, Katy RA Hinton, Jonathan RA Hunter, Chris RA Jenkinson, Andy RA Jones, David RA Kosmidou, Vivian RA Lugg, Richard RA Menzies, Andrew RA Mironenko, Tatiana RA Parker, Adrian RA Perry, Janet RA Raine, Keiran Martin RA Richardson, David RA Shepherd, Rebecca RA Small, Alex RA Smith, Raffaella RA Solomon, Helen RA Stephens, Philip J. RA Teague, Jon W. RA Tofts, Calli RA Varian, Jennifer RA Webb, Tony RA West, Sofie RA Widaa, Sara RA Yates, Andy RA Reinhold, William C. RA Weinstein, John N. RA Stratton, Michael Rudolf RA Futreal, P. Andrew RA Wooster, Richard RT "Mutation analysis of 24 known cancer genes in the NCI-60 cell line RT set."; RL Mol. Cancer Ther. 5:2606-2612(2006). // RX PubMed=24670534; DOI=10.1371/journal.pone.0092047; PMCID=PMC3966786; RA Varma, Sudhir RA Pommier, Yves RA Sunshine, Margot RA Weinstein, John N. RA Reinhold, William C. RT "High resolution copy number variation data in the NCI-60 cancer cell RT lines from whole genome microarrays accessible through CellMiner."; RL PLoS ONE 9:e92047.1-e92047.15(2014). // RX PubMed=9041185; RA Johnson, Steven W. RA Laub, Paul B. RA Beesley, Jacqueline S. RA Ozols, Robert F. RA Hamilton, Thomas C. RT "Increased platinum-DNA damage tolerance is associated with cisplatin RT resistance and cross-resistance to various chemotherapeutic agents in RT unrelated human ovarian cancer cell lines."; RL Cancer Res. 57:850-856(1997). // RX PubMed=2041050; DOI=10.1093/jnci/83.11.757; RA Monks, Anne RA Scudiero, Dominic A. RA Skehan, Philip RA Shoemaker, Robert H. RA Paull, Kenneth D. RA Vistica, David T. RA Hose, Curtis D. RA Langley, John RA Cronise, Paul RA Vaigro-Wolff, Anne RA Gray-Goodrich, Marcia RA Campbell, Hugh RA Mayo, Joseph G. RA Boyd, Michael R. RT "Feasibility of a high-flux anticancer drug screen using a diverse RT panel of cultured human tumor cell lines."; RL J. Natl. Cancer Inst. 83:757-766(1991). // RX PubMed=22628656; DOI=10.1126/science.1218595; PMCID=PMC3526189; RA Jain, Mohit RA Nilsson, Roland RA Sharma, Sonia RA Madhusudhan, Nikhil RA Kitami, Toshimori RA Souza, Amanda L. RA Kafri, Ran RA Kirschner, Marc Wallace RA Clish, Clary B. RA Mootha, Vamsi Krishna RT "Metabolite profiling identifies a key role for glycine in rapid RT cancer cell proliferation."; RL Science 336:1040-1044(2012). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=7718330; DOI=10.1016/0959-8049(94)00472-H; RA Baguley, Bruce Charles RA Marshall, Elaine S. RA Whittaker, John Richard RA Dotchin, M.C. RA Nixon, Johanna RA McCrystal, Michael R. RA Finlay, Graeme John RA Matthews, John H.L. RA Holdaway, Karen M. RA van Zijl, Pierre Leonardus RT "Resistance mechanisms determining the in vitro sensitivity to RT paclitaxel of tumour cells cultured from patients with ovarian RT cancer."; RL Eur. J. Cancer 31A:230-237(1995). // RX PubMed=22336246; DOI=10.1016/j.bmc.2012.01.017; RA Kong, De-Xin RA Yamori, Takao RT "JFCR39, a panel of 39 human cancer cell lines, and its application in RT the discovery and development of anticancer drugs."; RL Bioorg. Med. Chem. 20:1947-1951(2012). // RX PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878; RA Scholtalbers, Jelle RA Boegel, Sebastian RA Bukur, Thomas RA Byl, Marius RA Goerges, Sebastian RA Sorn, Patrick RA Loewer, Martin RA Sahin, Ugur RA Castle, John C. RT "TCLP: an online cancer cell line catalogue integrating HLA type, RT predicted neo-epitopes, virus and gene expression."; RL Genome Med. 7:118.1-118.7(2015). // RX PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775; RA Goncalves, Emanuel RA Poulos, Rebecca C. RA Cai, Zhao-Xiang RA Barthorpe, Syd RA Manda, Srikanth S. RA Lucas, Natasha RA Beck, Alexandra RA Bucio-Noble, Daniel RA Dausmann, Michael RA Hall, Caitlin RA Hecker, Michael RA Koh, Jennifer RA Lightfoot, Howard RA Mahboob, Sadia RA Mali, Iman RA Morris, James RA Richardson, Laura RA Seneviratne, Akila J. RA Shepherd, Rebecca RA Sykes, Erin RA Thomas, Frances RA Valentini, Sara RA Williams, Steven G. RA Wu, Yang-Xiu RA Xavier, Dylan RA MacKenzie, Karen L. RA Hains, Peter G. RA Tully, Brett RA Robinson, Phillip James RA Zhong, Qing RA Garnett, Mathew J. RA Reddel, Roger Robert RT "Pan-cancer proteomic map of 949 human cell lines."; RL Cancer Cell 40:835-849.e8(2022). // RX PubMed=22068913; DOI=10.1073/pnas.1111840108; PMCID=PMC3219108; RA Gillet, Jean-Pierre RA Calcagno, Anna Maria RA Varma, Sudhir RA Marino, Miguel RA Green, Lisa J. RA Vora, Meena I. RA Patel, Chirayu RA Orina, Josiah N. RA Eliseeva, Tatiana A. RA Singal, Vineet RA Padmanabhan, Raji RA Davidson, Ben RA Ganapathi, Ram RA Sood, Anil K. RA Rueda, Bo R. RA Ambudkar, Suresh V. RA Gottesman, Michael Marc RT "Redefining the relevance of established cancer cell lines to the RT study of mechanisms of clinical anti-cancer drug resistance."; RL Proc. Natl. Acad. Sci. U.S.A. 108:18708-18713(2011). // RX PubMed=22384151; DOI=10.1371/journal.pone.0032096; PMCID=PMC3285665; RA Lee, Jun-Seok RA Kim, Yun Kyung RA Kim, Han Jo RA Hajar, Siti RA Tan, Yee Ling RA Kang, Nam-Young RA Ng, Shin Hui RA Yoon, Chang No RA Chang, Young-Tae RT "Identification of cancer cell-line origins using fluorescence RT image-based phenomic screening."; RL PLoS ONE 7:e32096.1-e32096.8(2012). // RX PubMed=30971826; DOI=10.1038/s41586-019-1103-9; RA Behan, Fiona M. RA Iorio, Francesco RA Picco, Gabriele RA Goncalves, Emanuel RA Beaver, Charlotte M. RA Migliardi, Giorgia RA Santos, Rita RA Rao, Yanhua RA Sassi, Francesco RA Pinnelli, Marika RA Ansari, Rizwan RA Harper, Sarah RA Jackson, David Adam RA McRae, Rebecca RA Pooley, Rachel RA Wilkinson, Piers RA van der Meer, Dieudonne J. RA Dow, David RA Buser-Doepner, Carolyn A. RA Bertotti, Andrea RA Trusolino, Livio RA Stronach, Euan Alexander RA Saez-Rodriguez, Julio RA Yusa, Kosuke RA Garnett, Mathew J. RT "Prioritization of cancer therapeutic targets using CRISPR-Cas9 RT screens."; RL Nature 568:511-516(2019). // RX PubMed=9331090; RA O'Connor, Patrick M. RA Jackman, Joany RA Bae, Insoo RA Myers, Timothy Gene RA Fan, Sai-Jun RA Mutoh, Masato RA Scudiero, Dominic A. RA Monks, Anne RA Sausville, Edward A. RA Weinstein, John N. RA Friend, Stephen H. RA Fornace, Albert J. Jr. RA Kohn, Kurt W. RT "Characterization of the p53 tumor suppressor pathway in cell lines of RT the National Cancer Institute anticancer drug screen and correlations RT with the growth-inhibitory potency of 123 anticancer agents."; RL Cancer Res. 57:4285-4300(1997). // RX PubMed=10700174; DOI=10.1038/73432; RA Ross, Douglas T. RA Scherf, Uwe RA Eisen, Michael Bruce RA Perou, Charles M. RA Rees, Christian RA Spellman, Paul T. RA Iyer, Vishwanath R. RA Jeffrey, Stefanie S. RA van de Rijn, Matt RA Waltham, Mark C. RA Pergamenschikov, Alexander RA Lee, Jeffrey C.F. RA Lashkari, Deval RA Shalon, Dari RA Myers, Timothy Gene RA Weinstein, John N. RA Botstein, David RA Brown, Patrick O'Reilly RT "Systematic variation in gene expression patterns in human cancer cell RT lines."; RL Nat. Genet. 24:227-235(2000). // RX PubMed=3335022; RA Alley, Michael Curtis RA Scudiero, Dominic A. RA Monks, Anne RA Hursey, Miriam L. RA Czerwinski, Maciej J. RA Fine, Donald L. RA Abbott, Betty Jane RA Mayo, Joseph G. RA Shoemaker, Robert H. RA Boyd, Michael R. RT "Feasibility of drug screening with panels of human tumor cell lines RT using a microculture tetrazolium assay."; RL Cancer Res. 48:589-601(1988). // RX PubMed=25877200; DOI=10.1038/nature14397; RA Yu, Ma-Mie RA Selvaraj, Suresh K. RA Liang-Chu, May M.Y. RA Aghajani, Sahar RA Busse, Matthew RA Yuan, Jean RA Lee, Genee RA Peale, Franklin V. RA Klijn, Christiaan RA Bourgon, Richard RA Kaminker, Joshua S. RA Neve, Richard M. RT "A resource for cell line authentication, annotation and quality RT control."; RL Nature 520:307-311(2015). // RX PubMed=24279929; DOI=10.1186/2049-3002-1-20; PMCID=PMC4178206; RA Dolfi, Sonia C. RA Chan, Leo Li-Ying RA Qiu, Jean RA Tedeschi, Philip M. RA Bertino, Joseph Rocco RA Hirshfield, Kim Marie RA Oltvai, Zoltan Nagy RA Vazquez, Alexei RT "The metabolic demands of cancer cells are coupled to their size and RT protein synthesis rates."; RL Cancer Metab. 1:20.1-20.13(2013). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=21912889; DOI=10.1007/s10637-011-9744-z; RA Sutherland, Hamish S. RA Hwang, In Young RA Marshall, Elaine S. RA Lindsay, Brent S. RA Denny, William Alexander RA Gilchrist, Catherine RA Joseph, Wayne R. RA Greenhalgh, Debra RA Richardson, Emma RA Kestell, Philip RA Ding, Angela RA Baguley, Bruce Charles RT "Therapeutic reactivation of mutant p53 protein by quinazoline RT derivatives."; RL Invest. New Drugs 30:2035-2045(2012). // RX PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254; RA Nusinow, David Paul RA Szpyt, John RA Ghandi, Mahmoud RA Rose, Christopher M. RA McDonald, E. Robert 3rd RA Kalocsay, Marian RA Jane-Valbuena, Judit RA Gelfand, Ellen T. RA Schweppe, Devin Karl RA Jedrychowski, Mark P. RA Golji, Javad RA Porter, Dale A. RA Rejtar, Tomas RA Wang, Y. Karen RA Kryukov, Gregory V. RA Stegmeier, Frank RA Erickson, Brian K. RA Garraway, Levi Alexander RA Sellers, William Raj RA Gygi, Steven P. RT "Quantitative proteomics of the Cancer Cell Line Encyclopedia."; RL Cell 180:387-402.e16(2020). // RX PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023; RA Stordal, Britta RA Timms, Kirsten RA Farrelly, Angela RA Gallagher, Danielle RA Busschots, Steven RA Renaud, Mickael RA Thery, Julien RA Williams, Deborah RA Potter, Jennifer RA Tran, Thanh RA Korpanty, Greg RA Cremona, Mattia RA Carey, Mark S. RA Li, Jie RA Li, Yang RA Aslan, Ozlem RA O'Leary, John J. RA Mills, Gordon B. RA Hennessy, Bryan T. RT "BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one RT functionally deleterious BRCA1 mutation."; RL Mol. Oncol. 7:567-579(2013). // RX PubMed=1348364; DOI=10.1073/pnas.89.7.3070; PMCID=PMC48805; RA Godwin, Andrew Kent RA Meister, Alton RA O'Dwyer, Peter J. RA Huang, Chin-Shiou RA Hamilton, Thomas C. RA Anderson, Mary E. RT "High resistance to cisplatin in human ovarian cancer cell lines is RT associated with marked increase of glutathione synthesis."; RL Proc. Natl. Acad. Sci. U.S.A. 89:3070-3074(1992). // RX PubMed=31733513; DOI=10.1016/j.isci.2019.10.059; PMCID=PMC6889472; RA Guo, Tian-Nan RA Luna, Augustin RA Rajapakse, Vinodh N. RA Koh, Gene Ching-Chiek RA Wu, Zhi-Cheng RA Liu, Wei RA Sun, Yao-Ting RA Gao, Huan-Huan RA Menden, Michael Patrick RA Xu, Chao RA Calzone, Laurence RA Martignetti, Loredana RA Auwerx, Chiara RA Buljan, Marija RA Banaei-Esfahani, Amir RA Ori, Alessandro RA Iskar, Murat RA Gillet, Ludovic C. RA Bi, Ran RA Zhang, Jiang-Nan RA Zhang, Huan-Huan RA Yu, Chen-Huan RA Zhong, Qing RA Varma, Sudhir RA Schmitt, Uwe RA Qiu, Peng RA Zhang, Qiu-Shi RA Zhu, Yi RA Wild, Peter Johannes RA Garnett, Mathew J. RA Bork, Peer RA Beck, Martin RA Liu, Ke-Xin RA Saez-Rodriguez, Julio RA Elloumi, Fathi RA Reinhold, William C. RA Sander, Chris RA Pommier, Yves RA Aebersold, Ruedi RT "Quantitative proteome landscape of the NCI-60 cancer cell lines."; RL iScience 21:664-680(2019). // RX PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866; RA Domcke, Silvia RA Sinha, Rileen RA Levine, Douglas A. RA Sander, Chris RA Schultz, Nikolaus RT "Evaluating cell lines as tumour models by comparison of genomic RT profiles."; RL Nat. Commun. 4:2126.1-2126.10(2013). // RX PubMed=25485619; DOI=10.1038/nbt.3080; RA Klijn, Christiaan RA Durinck, Steffen RA Stawiski, Eric W. RA Haverty, Peter M. RA Jiang, Zhao-Shi RA Liu, Han-Bin RA Degenhardt, Jeremiah RA Mayba, Oleg RA Gnad, Florian RA Liu, Jin-Feng RA Pau, Gregoire RA Reeder, Jens RA Cao, Yi RA Mukhyala, Kiran RA Selvaraj, Suresh K. RA Yu, Ma-Mie RA Zynda, Gregory J. RA Brauer, Matthew J. RA Wu, Thomas D. RA Gentleman, Robert Clifford RA Manning, Gerard RA Yauch, Robert L. RA Bourgon, Richard RA Stokoe, David RA Modrusan, Zora RA Neve, Richard M. RA de Sauvage, Frederic J. RA Settleman, Jeffrey RA Seshagiri, Somasekar RA Zhang, Ze-Min RT "A comprehensive transcriptional portrait of human cancer cell RT lines."; RL Nat. Biotechnol. 33:306-312(2015). // RX PubMed=27235858; DOI=10.1016/j.ygyno.2016.05.028; PMCID=PMC4961516; RA Hernandez, Lidia RA Kim, Marianne K. RA Lyle, L. Tiffany RA Bunch, Kristen Paige RA House, Carrie D. RA Ning, Franklin RA Noonan, Anne M. RA Annunziata, Christina Messineo RT "Characterization of ovarian cancer cell lines as in vivo models for RT preclinical studies."; RL Gynecol. Oncol. 142:332-340(2016). // RX PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945; RA Papp, Eniko RA Hallberg, Dorothy RA Konecny, Gottfried E. RA Bruhm, Daniel C. RA Adleff, Vilmos RA Noe, Michael RA Kagiampakis, Ioannis RA Palsgrove, Doreen RA Conklin, Dylan RA Kinose, Yasuto RA White, James R. RA Press, Michael Frederick RA Drapkin, Ronny I. RA Easwaran, Hariharan RA Baylin, Stephen Bruce RA Slamon, Dennis Joseph RA Velculescu, Victor E. RA Scharpf, Robert B. RT "Integrated genomic, epigenomic, and expression analyses of ovarian RT cancer cell lines."; RL Cell Rep. 25:2617-2633(2018). // RX PubMed=27807467; DOI=10.1186/s13100-016-0078-4; PMCID=PMC5087121; RA Zampella, John G. RA Rodic, Nemanja RA Yang, Wan Rou RA Huang, Cheng Ran Lisa RA Welch, Jane RA Gnanakkan, Veena P. RA Cornish, Toby Charles RA Boeke, Jef D. RA Burns, Kathleen H. RT "A map of mobile DNA insertions in the NCI-60 human cancer cell RT panel."; RL Mob. DNA 7:20.1-20.11(2016). // RX PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677; RA Korch, Christopher T. RA Spillman, Monique Ann RA Jackson, Twila A. RA Jacobsen, Britta M. RA Murphy, Susan K. RA Lessey, Bruce Arthur RA Jordan, Virgil Craig RA Bradford, Andrew Peter RT "DNA profiling analysis of endometrial and ovarian cell lines reveals RT misidentification, redundancy and contamination."; RL Gynecol. Oncol. 127:241-248(2012). // RX PubMed=38861359; DOI=10.1158/0008-5472.CAN-23-3031; PMCID=PMC11292194; RA Kunkel, Mark W. RA Coussens, Nathan P. RA Morris, Joel RA Taylor, Ronald C. RA Dexheimer, Thomas S. RA Jones, Eric M. RA Doroshow, James H. RA Teicher, Beverly A. RT "HTS384 NCI60: the next phase of the NCI60 screen."; RL Cancer Res. 84:2403-2416(2024). // RX PubMed=2307530; DOI=10.1002/ijc.2910450306; RA Schilder, Russell J. RA Hall, Lemuel RA Monks, Anne RA Handel, Laura M. RA Fornace, Albert J. Jr. RA Ozols, Robert F. RA Fojo, Antonio RA Hamilton, Thomas C. RT "Metallothionein gene expression and resistance to cisplatin in human RT ovarian cancer."; RL Int. J. Cancer 45:416-422(1990). // RX PubMed=12960427; DOI=10.1091/mbc.E03-05-0279; PMCID=PMC266758; RA Schaner, Marci E. RA Ross, Douglas T. RA Ciaravino, Giuseppe RA Sorlie, Therese RA Troyanskaya, Olga G. RA Diehn, Maximilian RA Wang, Yan C. RA Duran, George E. RA Sikic, Thomas L. RA Caldeira, Sandra RA Skomedal, Hanne RA Tu, I-Ping RA Hernandez-Boussard, Tina RA Johnson, Steven W. RA O'Dwyer, Peter J. RA Fero, Michael J. RA Kristensen, Gunnar B. RA Borresen-Dale, Anne-Lise RA Hastie, Trevor John RA Tibshirani, Robert John RA van de Rijn, Matt RA Teng, Nelson N.H. RA Longacre, Teri A. RA Botstein, David RA Brown, Patrick O'Reilly RA Sikic, Branimir Ivan RT "Gene expression patterns in ovarian carcinomas."; RL Mol. Biol. Cell 14:4376-4386(2003). // RX PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113; RA Bignell, Graham Robert RA Greenman, Christopher D. RA Davies, Helen R. RA Butler, Adam P. RA Edkins, Sarah RA Andrews, Jenny M. RA Buck, Gemma RA Chen, Lina RA Beare, David RA Latimer, Calli RA Widaa, Sara RA Hinton, Jonathan RA Fahey, Ciara RA Fu, Bei-Yuan RA Swamy, Sajani RA Dalgliesh, Gillian L. RA Teh, Bin Tean RA Deloukas, Panos RA Yang, Feng-Tang RA Campbell, Peter J. RA Futreal, P. Andrew RA Stratton, Michael Rudolf RT "Signatures of mutation and selection in the cancer genome."; RL Nature 463:893-898(2010). // RX PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652; RA Cowley, Glenn S. RA Weir, Barbara A. RA Vazquez, Francisca RA Tamayo, Pablo RA Scott, Justine A. RA Rusin, Scott RA East-Seletsky, Alexandra RA Ali, Levi D. RA Gerath, William F.J. RA Pantel, Sarah E. RA Lizotte, Patrick Hall RA Jiang, Guo-Zhi RA Hsiao, Jessica RA Tsherniak, Aviad RA Dwinell, Elizabeth RA Aoyama, Simon RA Okamoto, Michael RA Harrington, William RA Gelfand, Ellen T. RA Green, Thomas M. RA Tomko, Mark J. RA Gopal, Shuba RA Wong, Terence C. RA Li, Hu-Bo RA Howell, Sara RA Stransky, Nicolas RA Liefeld, Ted RA Jang, Dongkeun RA Bistline, Jonathan RA Meyers, Barbara Hill RA Armstrong, Scott Allen RA Anderson, Kenneth Carl RA Stegmaier, Kimberly RA Reich, Michael RA Pellman, David RA Boehm, Jesse S. RA Mesirov, Jill P. RA Golub, Todd Robert RA Root, David E. RA Hahn, William Chun RT "Parallel genome-scale loss of function screens in 216 cancer cell RT lines for the identification of context-specific genetic RT dependencies."; RL Sci. Data 1:140035.1-140035.12(2014). // RX PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396; RA Marcotte, Richard RA Brown, Kevin R. RA Suarez Saiz, Fernando Jose RA Sayad, Azin RA Karamboulas, Konstantina RA Krzyzanowski, Paul M. RA Sircoulomb, Fabrice RA Medrano, Mauricio RA Fedyshyn, Yaroslav RA Koh, Judice Lie-Yong RA van Dyk, Dewald RA Fedyshyn, Bohdana RA Luhova, Marianna RA Brito, Glauber C. RA Vizeacoumar, Franco J. RA Vizeacoumar, Frederick S. RA Datti, Alessandro RA Kasimer, Dahlia RA Buzina, Alla RA Mero, Patricia RA Misquitta, Christine RA Normand, Josee RA Haider, Maliha RA Ketela, Troy RA Wrana, Jeffrey L. RA Rottapel, Robert RA Neel, Benjamin G. RA Moffat, Jason RT "Essential gene profiles in breast, pancreatic, and ovarian cancer RT cells."; RL Cancer Discov. 2:172-189(2012). // RX PubMed=27377824; DOI=10.1038/sdata.2016.52; PMCID=PMC4932877; RA Mestdagh, Pieter RA Lefever, Steve RA Volders, Pieter-Jan RA Derveaux, Stefaan RA Hellemans, Jan RA Vandesompele, Jo RT "Long non-coding RNA expression profiling in the NCI60 cancer cell RT line panel using high-throughput RT-qPCR."; RL Sci. Data 3:160052.1-160052.6(2016). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=19372543; DOI=10.1158/1535-7163.MCT-08-0921; PMCID=PMC4020356; RA Lorenzi, Philip L. RA Reinhold, William C. RA Varma, Sudhir RA Hutchinson, Amy A. RA Pommier, Yves RA Chanock, Stephen Jacob RA Weinstein, John N. RT "DNA fingerprinting of the NCI-60 cell line panel."; RL Mol. Cancer Ther. 8:713-724(2009). // RX DOI=10.4172/2157-7145.S2-005; RA Fang, Ri-Xun RA Shewale, Jaiprakash G. RA Nguyen, Vivian T. RA Cardoso, Holly RA Swerdel, Mavis R. RA Hart, Ronald P. RA Furtado, Manohar R. RT "STR profiling of human cell lines: challenges and possible solutions RT to the growing problem."; RL J. Forensic Res. 2 Suppl. 2:5-5(2011). // RX PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469; RA Iorio, Francesco RA Knijnenburg, Theo A. RA Vis, Daniel J. RA Bignell, Graham Robert RA Menden, Michael Patrick RA Schubert, Michael RA Aben, Nanne RA Goncalves, Emanuel RA Barthorpe, Syd RA Lightfoot, Howard RA Cokelaer, Thomas RA Greninger, Patricia RA van Dyk, Ewald RA Chang, Han RA de Silva, Heshani RA Heyn, Holger RA Deng, Xian-Ming RA Egan, Regina K. RA Liu, Qing-Song RA Mironenko, Tatiana RA Mitropoulos, Xeni RA Richardson, Laura RA Wang, Jin-Hua RA Zhang, Ting-Hu RA Moran, Sebastian RA Sayols, Sergi RA Soleimani, Maryam RA Tamborero, David RA Lopez-Bigas, Nuria RA Ross-Macdonald, Petra RA Esteller, Manel RA Gray, Nathanael S. RA Haber, Daniel Arie RA Stratton, Michael Rudolf RA Benes, Cyril Henri RA Wessels, Lodewyk F.A. RA Saez-Rodriguez, Julio RA McDermott, Ultan RA Garnett, Mathew J. RT "A landscape of pharmacogenomic interactions in cancer."; RL Cell 166:740-754(2016). // RX PubMed=12417041; DOI=10.1111/j.1349-7006.2002.tb01213.x; PMCID=PMC5926887; RA Watanabe, Takafumi RA Imoto, Issei RA Katahira, Tomoyuki RA Hirasawa, Akira RA Ishiwata, Isamu RA Emi, Mitsuru RA Takayama, Masaomi RA Sato, Akira RA Inazawa, Johji RT "Differentially regulated genes as putative targets of amplifications RT at 20q in ovarian cancers."; RL Jpn. J. Cancer Res. 93:1114-1122(2002). // RX PubMed=23933261; DOI=10.1016/j.celrep.2013.07.018; RA Moghaddas Gholami, Amin RA Hahne, Hannes RA Wu, Zhi-Xiang RA Auer, Florian Johann RA Meng, Chen RA Wilhelm, Mathias RA Kuster, Bernhard RT "Global proteome analysis of the NCI-60 cell line panel."; RL Cell Rep. 4:609-620(2013). // RX PubMed=24023729; DOI=10.1371/journal.pone.0072162; PMCID=PMC3762837; RA Anglesio, Michael S. RA Wiegand, Kimberly C. RA Melnyk, Nataliya RA Chow, Christine RA Salamanca, Clara M. RA Prentice, Leah M. RA Senz, Janine RA Yang, Winnie RA Spillman, Monique Ann RA Cochrane, Dawn R. RA Shumansky, Karey RA Shah, Sohrab P. RA Kalloger, Steve E. RA Huntsman, David G. RT "Type-specific cell line models for type-specific ovarian cancer RT research."; RL PLoS ONE 8:e72162.1-e72162.13(2013). // RX PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028; RA Medrano, Mauricio RA Communal, Laudine RA Brown, Kevin R. RA Iwanicki, Marcin RA Normand, Josee RA Paterson, Joshua RA Sircoulomb, Fabrice RA Krzyzanowski, Paul M. RA Novak, Marian RA Doodnauth, Sasha A. RA Suarez Saiz, Fernando Jose RA Cullis, Jane RA Al-awar, Rima RA Neel, Benjamin G. RA McPherson, John RA Drapkin, Ronny I. RA Ailles, Laurie RA Mes-Masson, Anne-Marie RA Rottapel, Robert RT "Interrogation of functional cell-surface markers identifies CD151 RT dependency in high-grade serous ovarian cancer."; RL Cell Rep. 18:2343-2358(2017). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=20204287; DOI=10.3892/or_00000728; PMCID=PMC2909445; RA Langland, Gregory T. RA Yannone, Steven M. RA Langland, Rachel A. RA Nakao, Aki RA Guan, Ying-Hui RA Long, Sydney B.T. RA Vonguyen, Lien RA Chen, David J. RA Gray, Joe W. RA Chen, Fan-Qing RT "Radiosensitivity profiles from a panel of ovarian cancer cell lines RT exhibiting genetic alterations in p53 and disparate DNA-dependent RT protein kinase activities."; RL Oncol. Rep. 23:1021-1026(2010). // RX PubMed=23856246; DOI=10.1158/0008-5472.CAN-12-3342; PMCID=PMC4893961; RA Abaan, Ogan Demir RA Polley, Eric C. RA Davis, Sean R. RA Zhu, Yue-Lin J. RA Bilke, Sven RA Walker, Robert L. RA Pineda, Marbin A. RA Gindin, Yevgeniy RA Jiang, Yuan RA Reinhold, William C. RA Holbeck, Susan L. RA Simon, Richard M. RA Doroshow, James H. RA Pommier, Yves RA Meltzer, Paul S. RT "The exomes of the NCI-60 panel: a genomic resource for cancer biology RT and systems pharmacology."; RL Cancer Res. 73:4372-4382(2013). //