ID OC 316 AC CVCL_1618 SY OC-316; OC316 DR BTO; BTO_0006437 DR CLO; CLO_0008233 DR BioSample; SAMN10987675 DR cancercelllines; CVCL_1618 DR Cell_Model_Passport; SIDM00219 DR DepMap; ACH-001145 DR GEO; GSM887467 DR GEO; GSM888547 DR IARC_TP53; 21597 DR ICLC; HTL98014 DR PharmacoDB; OC316_1181_2019 DR Progenetix; CVCL_1618 DR Wikidata; Q54931703 RX PubMed=8690298; RX PubMed=15677628; RX PubMed=22460905; RX PubMed=23415752; RX PubMed=23839242; RX PubMed=28196595; RX PubMed=30894373; RX PubMed=31068700; WW Info; MCLP; -; https://tcpaportal.org/mclp/ CC Problematic cell line: Contaminated. Identical to OC 314 according to STR profiling done at ICLC, to MSI data (PubMed=15677628) and to omic data (DepMap). Originally thought to originate from a 60 year old patient with a FIGO stage IV ovarian cancer. CC Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). CC Part of: MD Anderson Cell Lines Project. CC Population: Caucasian. CC Microsatellite instability: Instable (MSI-high) (PubMed=15677628; PubMed=31068700). CC Sequence variation: Mutation; HGNC; HGNC:914; B2M; Simple; p.Leu15Phefs*41 (c.43_44delCT); Zygosity=Heterozygous (DepMap=ACH-001145). CC Sequence variation: Mutation; HGNC; HGNC:10447; RRAS; Simple; p.Pro26fs (c.74delC); Zygosity=Heterozygous (DepMap=ACH-001145). CC Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (DepMap=ACH-001145). CC Omics: Genomics; Whole exome sequencing. CC Omics: Proteomics; Expression; Reverse-phase protein array. CC Omics: Transcriptomics; Microarray. CC Omics: Variations; SNP array analysis. CC Genome ancestry: African=0%; Native American=1.57%; East Asian, North=1.31%; East Asian, South=0%; South Asian=0%; European, North=75.5%; European, South=21.63% (PubMed=30894373). CC Discontinued: ICLC; HTL98014; true. CC Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795. DI NCIt; C7550; Ovarian serous adenocarcinoma OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_1616 ! OC 314 SX Female AG 39Y CA Cancer cell line DT Created: 04-04-12; Last updated: 10-04-25; Version: 28 // RX PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866; RA Domcke, Silvia RA Sinha, Rileen RA Levine, Douglas A. RA Sander, Chris RA Schultz, Nikolaus RT "Evaluating cell lines as tumour models by comparison of genomic RT profiles."; RL Nat. Commun. 4:2126.1-2126.10(2013). // RX PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027; RA Barretina, Jordi Ginesta RA Caponigro, Giordano RA Stransky, Nicolas RA Venkatesan, Kavitha RA Margolin, Adam A. RA Kim, Sungjoon RA Wilson, Christopher J. RA Lehar, Joseph RA Kryukov, Gregory V. RA Sonkin, Dmitriy RA Reddy, Anupama RA Liu, Manway RA Murray, Lauren RA Berger, Michael F. RA Monahan, John E. RA Morais, Paula RA Meltzer, Jodi RA Korejwa, Adam RA Jane-Valbuena, Judit RA Mapa, Felipa A. RA Thibault, Joseph RA Bric-Furlong, Eva RA Raman, Pichai RA Shipway, Aaron RA Engels, Ingo H. RA Cheng, Jill RA Yu, Guo-Ying K. RA Yu, Jian-Jun RA Aspesi, Peter Jr. RA de Silva, Melanie RA Jagtap, Kalpana RA Jones, Michael D. RA Wang, Li RA Hatton, Charles RA Palescandolo, Emanuele RA Gupta, Supriya RA Mahan, Scott RA Sougnez, Carrie RA Onofrio, Robert C. RA Liefeld, Ted RA MacConaill, Laura Eleanor RA Winckler, Wendy RA Reich, Michael RA Li, Nan-Xin RA Mesirov, Jill P. RA Gabriel, Stacey B. RA Getz, Gad RA Ardlie, Kristin RA Chan, Vivien RA Myer, Vic E. RA Weber, Barbara L. RA Porter, Jeff RA Warmuth, Markus RA Finan, Peter RA Harris, Jennifer L. RA Meyerson, Matthew Langer RA Golub, Todd Robert RA Morrissey, Michael P. RA Sellers, William Raj RA Schlegel, Robert RA Garraway, Levi Alexander RT "The Cancer Cell Line Encyclopedia enables predictive modelling of RT anticancer drug sensitivity."; RL Nature 483:603-607(2012). // RX PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076; RA Li, Jun RA Zhao, Wei RA Akbani, Rehan RA Liu, Wen-Bin RA Ju, Zhen-Lin RA Ling, Shi-Yun RA Vellano, Christopher P. RA Roebuck, Paul RA Yu, Qing-Hua RA Eterovic, Agda Karina RA Byers, Lauren Averett RA Davies, Michael A. RA Deng, Wan-Leng RA Gopal, Y.N. Vashisht RA Chen, Guo RA von Euw, Erika Maria RA Slamon, Dennis Joseph RA Conklin, Dylan RA Heymach, John Victor RA Gazdar, Adi F. RA Minna, John D. RA Myers, Jeffrey N. RA Lu, Yi-Ling RA Mills, Gordon B. RA Liang, Han RT "Characterization of human cancer cell lines by reverse-phase protein RT arrays."; RL Cancer Cell 31:225-239(2017). // RX PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675; RA Dutil, Julie RA Chen, Zhi-Hua RA Monteiro, Alvaro N.A. RA Teer, Jamie K. RA Eschrich, Steven A. RT "An interactive resource to probe genetic diversity and estimated RT ancestry in cancer cell lines."; RL Cancer Res. 79:1263-1273(2019). // RX PubMed=8690298; DOI=10.1006/gyno.1996.0194; RA Alama, Angela RA Barbieri, Federica RA Favre, Anna RA Cagnoli, Monica RA Noviello, Elvira RA Pedulla, Franco RA Viale, Maurizio RA Foglia, Gianni RA Ragni, Nicola RT "Establishment and characterization of three new cell lines derived RT from the ascites of human ovarian carcinomas."; RL Gynecol. Oncol. 62:82-88(1996). // RX PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023; RA Stordal, Britta RA Timms, Kirsten RA Farrelly, Angela RA Gallagher, Danielle RA Busschots, Steven RA Renaud, Mickael RA Thery, Julien RA Williams, Deborah RA Potter, Jennifer RA Tran, Thanh RA Korpanty, Greg RA Cremona, Mattia RA Carey, Mark S. RA Li, Jie RA Li, Yang RA Aslan, Ozlem RA O'Leary, John J. RA Mills, Gordon B. RA Hennessy, Bryan T. RT "BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one RT functionally deleterious BRCA1 mutation."; RL Mol. Oncol. 7:567-579(2013). // RX PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103; RA Ghandi, Mahmoud RA Huang, Franklin W. RA Jane-Valbuena, Judit RA Kryukov, Gregory V. RA Lo, Christopher C. RA McDonald, E. Robert 3rd RA Barretina, Jordi Ginesta RA Gelfand, Ellen T. RA Bielski, Craig M. RA Li, Hao-Xin RA Hu, Kevin RA Andreev-Drakhlin, Alexander Y. RA Kim, Jaegil RA Hess, Julian M. RA Haas, Brian J. RA Aguet, Francois RA Weir, Barbara A. RA Rothberg, Michael V. RA Paolella, Brenton R. RA Lawrence, Michael Scott RA Akbani, Rehan RA Lu, Yi-Ling RA Tiv, Hong L. RA Gokhale, Prafulla C. RA de Weck, Antoine RA Mansour, Ali Amin RA Oh, Coyin RA Shih, Juliann RA Hadi, Kevin RA Rosen, Yanay RA Bistline, Jonathan RA Venkatesan, Kavitha RA Reddy, Anupama RA Sonkin, Dmitriy RA Liu, Manway RA Lehar, Joseph RA Korn, Joshua M. RA Porter, Dale A. RA Jones, Michael D. RA Golji, Javad RA Caponigro, Giordano RA Taylor, Jordan E. RA Dunning, Caitlin M. RA Creech, Amanda L. RA Warren, Allison C. RA McFarland, James M. RA Zamanighomi, Mahdi RA Kauffmann, Audrey RA Stransky, Nicolas RA Imielinski, Marcin RA Maruvka, Yosef E. RA Cherniack, Andrew D. RA Tsherniak, Aviad RA Vazquez, Francisca RA Jaffe, Jacob D. RA Lane, Andrew Alan RA Weinstock, David M. RA Johannessen, Cory M. RA Morrissey, Michael P. RA Stegmeier, Frank RA Schlegel, Robert RA Hahn, William Chun RA Getz, Gad RA Mills, Gordon B. RA Boehm, Jesse S. RA Golub, Todd Robert RA Garraway, Levi Alexander RA Sellers, William Raj RT "Next-generation characterization of the Cancer Cell Line RT Encyclopedia."; RL Nature 569:503-508(2019). // RX PubMed=15677628; DOI=10.1093/carcin/bgi032; RA Gorringe, Kylie Louise RA Chin, Suet-Feung RA Pharoah, Paul D.P. RA Staines, Joanne M. RA Oliveira, Carla RA Edwards, Paul A.W. RA Caldas, Carlos RT "Evidence that both genetic instability and selection contribute to RT the accumulation of chromosome alterations in cancer."; RL Carcinogenesis 26:923-930(2005). //